This 2019 Washington rodent study from Dr. Michael Skinner’s lab found adverse effects in the grand-offspring and great-grand-offspring following their ancestor’s exposure during pregnancy to the world’s most commonly used herbicide: “Using a transient exposure of gestating F0 generation female rats found negligible impacts of glyphosate on the directly exposed F0 generation, or F1 generation … Continue reading The transgenerational impact of Roundup exposure
This 2018 French/Italian/Swiss rodent study was an extension of the work done by the group of researchers who performed Prenatal stress produces offspring who as adults have cognitive, emotional, and memory deficiencies and Treating prenatal stress-related disorders with an oxytocin receptor agonist: “Reduction of maternal behavior [nursing behavior, grooming, licking, carrying pups] was predictive of … Continue reading The lifelong impact of maternal postpartum behavior
This 2018 Canadian paper reviewed evidence for potential sex-specific differences in the lasting impacts of childhood trauma: “This paper will provide a contextualized summary of neuroendocrine, neuroimaging, and behavioral epigenetic studies on biological sex differences contributing to internalizing psychopathology, specifically posttraumatic stress disorder and depression, among adults with a history of childhood abuse. Given the … Continue reading Sex-specific impacts of childhood trauma
Was the recent Swiss avalanche’s cause the last, triggering snowflake, or the billions of snowflakes before it? There’s been a slight increase in the number of PNAS studies that included the “catastrophic” search word from October 2016 to mid-January 2018 compared to the January 2014 to mid-April 2015 period referenced in How well can catastrophes … Continue reading The impact of the last snowflake
Continuing with Dr. Arthur Janov’s May 2016 book Beyond Belief: “p. 17 When someone insults us, we immediately create reasons and rationales for it. We cover the pain. Now imagine a whole early childhood of insults and assaults and how that leaves a legacy that must be dealt with. The mind of ideas and philosophies … Continue reading Beyond Belief: The impact of merciless beatings on beliefs
This 2015 worldwide human study Hunger promotes acquisition of nonfood objects found that people’s current degree of hungriness affected their propensity to acquire nonfood items. The researchers admitted that they didn’t demonstrate cause and effect with the five experiments they performed, although the findings had merit. News articles poked good-natured fun at the findings with … Continue reading Do the impacts of early experiences of hunger affect our behavior, thoughts, and feelings today?
What I found curious in this 2012 UK review of 82 studies was the reviewer’s reluctance to highly regard a human’s life before birth, during infancy, and in early childhood. There was no lack in 2012 of animal studies to draw from to inferentially hypothesize how a human fetal environment causes the fetus to adapt … Continue reading Problematic research: Feigning naivety of the impact of prenatal, infancy and early childhood experiences
This 2020 plant study by the same university as Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts investigated seasonal and stressful effects on broccoli compounds: “In this study, three crop trials were carried out to evaluate effects of cultivation season, application of different dosages of methyl-jasmonate (MeJA) on overall quality … Continue reading Mild stress improves broccoli compound yields
This 2020 rodent study from the labs of Dr. Michael Skinner at Washington State University examined how great-grandmothers’ insect repellent exposures produced diseases in their great-grand offspring: “Permethrin and DEET are the pesticides and insect repellent most commonly used by humans. These pesticides have been shown to promote the epigenetic transgenerational inheritance of disease in … Continue reading DEET and permethrin cause transgenerational diseases
This 2020 study evaluated a broccoli sprout compound’s effects on breast cancer development: “Women who carry the BRCA mutation are at high lifetime risk of breast cancer, but there is no consensus regarding an effective and safe chemoprevention strategy. A large body of evidence suggests that 3,3-diindolylmethane (DIM), a dimer of indole-3-carbinol found in cruciferous … Continue reading DIM effects on BRCA carriers
Three papers investigated microwaving plant material for phenolic compounds. The first was a 2020 review that compared industry techniques: “Phenolic compounds are widely used as natural antioxidants and antimicrobial agents. They also exhibit antiallergenic, antiatherogenic, and anti-inflammatory activities. Although the nature and properties of raw materials strongly influence extraction, all extraction processes share major parameters: … Continue reading Microwaving broccoli sprouts may not affect phenolic levels
This 2020 meta-analysis subject was DHEA: “Twenty-four qualified trials were included in this meta-analysis. Statistically significant increases in serum IGF-1 levels were found only in participants who were: Women; or Supplementing 50 mg/d; or Undergoing intervention for > 12 weeks; or Without an underlying comorbidity; or Over the age of 60 years. DHEA supplementation led … Continue reading Take responsibility for your one precious life – DHEA
Ever heard about AGEs? Here are three papers that describe how AGEs affect humans. First is a 2020 Italian review Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System: “Neurodegenerative disease is an umbrella term for different conditions which primarily affect the neurons in the human brain. Currently, … Continue reading Get serious about advanced glycation end products (AGEs)
This 2017 review explored broccoli sprout compounds effects on head hair: “Skin appendages, notably hair follicles (HFs), can be exposed to high levels of reactive oxygen species (ROS), which are generated through metabolic reactions occurring mostly in the mitochondria, peroxisomes and the endoplasmic reticulum as well as in the plasma membrane. Despite their involvement in … Continue reading Eat broccoli sprouts for your hair!
This 2020 US/Sweden/Denmark human study measured twins during their old age: “We evaluate individual differences in DNA methylation at individual CpG sites across the methylome across 10 years in two Scandinavian samples of same‐sex aging twins. We test two competing hypotheses about the longitudinal stability and change in DNA methylation: The contribution of genetic influences … Continue reading A cherry-picked DNA methylation study