The impact of transgenerational epigenetic inheritance and early life experiences

A 2021 interview with McGill University’s Moshe Szyf: “There is a rejection of transgenerational inheritance as it goes against progressive thinking because it ties us to previous generations. The theory faces rejection because it sounds deterministic. But if you understand what epigenetics is, it’s not deterministic. There is stability, and there’s also room for dynamic … Continue reading The impact of transgenerational epigenetic inheritance and early life experiences

Part 2 of The transgenerational impact of Roundup exposure

This 2020 study followed up The transgenerational impact of Roundup exposure using the Washington State Unversity research group’s most recent methodology in DEET and permethrin cause transgenerational diseases: “The herbicide glyphosate has been shown to promote epigenetic transgenerational inheritance of pathology and disease in subsequent great-grand offspring (F3 generation). The current study was designed to … Continue reading Part 2 of The transgenerational impact of Roundup exposure

The transgenerational impact of Roundup exposure

This 2019 Washington rodent study from Dr. Michael Skinner’s lab found adverse effects in the grand-offspring and great-grand-offspring following their ancestor’s exposure during pregnancy to the world’s most commonly used herbicide: “Using a transient exposure of gestating F0 generation female rats found negligible impacts of glyphosate on the directly exposed F0 generation, or F1 generation … Continue reading The transgenerational impact of Roundup exposure

The lifelong impact of maternal postpartum behavior

This 2018 French/Italian/Swiss rodent study was an extension of the work done by the group of researchers who performed Prenatal stress produces offspring who as adults have cognitive, emotional, and memory deficiencies and Treating prenatal stress-related disorders with an oxytocin receptor agonist: “Reduction of maternal behavior [nursing behavior, grooming, licking, carrying pups] was predictive of … Continue reading The lifelong impact of maternal postpartum behavior

Sex-specific impacts of childhood trauma

This 2018 Canadian paper reviewed evidence for potential sex-specific differences in the lasting impacts of childhood trauma: “This paper will provide a contextualized summary of neuroendocrine, neuroimaging, and behavioral epigenetic studies on biological sex differences contributing to internalizing psychopathology, specifically posttraumatic stress disorder and depression, among adults with a history of childhood abuse. Given the … Continue reading Sex-specific impacts of childhood trauma

The impact of the last snowflake

Was the recent Swiss avalanche’s cause the last, triggering snowflake, or the billions of snowflakes before it? There’s been a slight increase in the number of PNAS studies that included the “catastrophic” search word from October 2016 to mid-January 2018 compared to the January 2014 to mid-April 2015 period referenced in How well can catastrophes … Continue reading The impact of the last snowflake

Beyond Belief: The impact of merciless beatings on beliefs

Continuing with Dr. Arthur Janov’s May 2016 book Beyond Belief: “p. 17 When someone insults us, we immediately create reasons and rationales for it. We cover the pain. Now imagine a whole early childhood of insults and assaults and how that leaves a legacy that must be dealt with. The mind of ideas and philosophies … Continue reading Beyond Belief: The impact of merciless beatings on beliefs

Do the impacts of early experiences of hunger affect our behavior, thoughts, and feelings today?

This 2015 worldwide human study Hunger promotes acquisition of nonfood objects found that people’s current degree of hungriness affected their propensity to acquire nonfood items. The researchers admitted that they didn’t demonstrate cause and effect with the five experiments they performed, although the findings had merit. News articles poked good-natured fun at the findings with … Continue reading Do the impacts of early experiences of hunger affect our behavior, thoughts, and feelings today?

Problematic research: Feigning naivety of the impact of prenatal, infancy and early childhood experiences

What I found curious in this 2012 UK review of 82 studies was the reviewer’s reluctance to highly regard a human’s life before birth, during infancy, and in early childhood. There was no lack in 2012 of animal studies to draw from to inferentially hypothesize how a human fetal environment causes the fetus to adapt … Continue reading Problematic research: Feigning naivety of the impact of prenatal, infancy and early childhood experiences

Human agency vs. brain dysfunction

This 2021 human study used epigenetic clock technology to assess chronic inflammation as a driver of cognitive decline through its effects on brain structure: “An epigenetic measure of C-reactive protein (DNAm CRP) was assembled for each participant. We found that higher inflammatory burden, indexed by DNAm CRP scores, associated with poor cognitive and neuroimaging brain … Continue reading Human agency vs. brain dysfunction

Save the bees with Brassicaceae seeds

Two 2021 papers, with the first studying bee infections: “Fungus Nosema ceranae represents one of the primary bee infection threats worldwide, and antibiotic fumagillin is the only registered product for nosemosis disease control. Natural bioactive compounds deriving from glucosinolate–myrosinase (GSL–MYR) in Brassicaceae plants, mainly isothiocyanates (ITCs), are known for antimicrobial activity against numerous pathogens and … Continue reading Save the bees with Brassicaceae seeds

Reworking evolutionary theory

Dr. Michael Skinner coauthored a 2021 review arguing for inclusion of epigenetic transgenerational inheritance into evolutionary theory: “Over the past 50 years, molecular technology has been used to investigate evolutionary biology. Many examples of finding no correlated genetic mutations or a low frequency of DNA sequence mutations suggest that additional mechanisms are also involved. Identical twins … Continue reading Reworking evolutionary theory

Broccoli sprout compounds and gut microbiota

Two 2021 reviews from one institution, with this first focused on aliphatic glucosinolates’ (GLS) metabolism to isothiocyanates (ITCs) like sulforaphane: “Human clinical trials examining efficacy of whole food interventions on cancer prevention targets have shown high levels of inter-individual variation in both absorption and excretion of ITCs. We discuss how consumption of cruciferous vegetables may … Continue reading Broccoli sprout compounds and gut microbiota

Dementia blood factors

This 2021 human study performed blood metabolite analyses: “Dementia is a collective term to describe various symptoms of cognitive impairment in a condition in which intelligence is irreversibly diminished due to acquired organic disorders of the brain, characterized by deterioration of memory, thinking, behavior, and the ability to perform daily activities. In this study, we … Continue reading Dementia blood factors

Changing your immune system / gut microbiota interactions with diet

This 2021 human clinical trial investigated associations between gut microbiota and host adaptive immune system components: “Diet modulates gut microbiome, and gut microbes impact the immune system. We used two gut microbiota-targeted dietary interventions – plant-based fiber or fermented foods – to determine how each influences microbiome and immune system in healthy adults. Using a … Continue reading Changing your immune system / gut microbiota interactions with diet