A cherry-picked DNA methylation study

This 2020 US/Sweden/Denmark human study measured twins during their old age: “We evaluate individual differences in DNA methylation at individual CpG sites across the methylome across 10 years in two Scandinavian samples of same‐sex aging twins. We test two competing hypotheses about the longitudinal stability and change in DNA methylation: The contribution of genetic influences … Continue reading A cherry-picked DNA methylation study

Topical sulforaphane protects skin

This 2020 Rutgers rodent study explored topical application of sulforaphane to prevent UVB-induced skin carcinogenesis: “We investigated the transcriptomic and DNA methylomic changes during tumor initiation, promotion, and progression and its impact and reversal by sulforaphane (SFN). The production of ROS and inflammation are closely linked to UVB-induced carcinogenesis. SFN protects skin cells from UVB-induced … Continue reading Topical sulforaphane protects skin

Eat sauerkraut today!

This 2017 Spanish article reviewed health benefits of sauerkraut: “During cabbage shredding and fermentation, a disruption of cabbage cells occurs, and GLS [glucosinolates] are hydrolyzed by myrosinase enzyme to a variety of GLS breakdown products. In particular, glucobrassicin is hydrolyzed into indol-3-carbinol (I3C) by myrosinase. As the pH decreases during cabbage fermentation, I3C reacts nonenzymatically … Continue reading Eat sauerkraut today!

Take responsibility for your one precious life – Zinc

This 2020 Russian review highlighted clinical data on zinc known before this year: “Zinc is known to modulate antiviral and antibacterial immunity and regulate inflammatory response. Zinc possesses anti-inflammatory activity by inhibiting NF-κB signaling and modulation of regulatory T-cell functions. The most critical role of zinc is demonstrated for the immune system. Zinc regulates proliferation, … Continue reading Take responsibility for your one precious life – Zinc

Microwave broccoli to increase flavonoid levels

This 2019 USDA study investigated representative broccoli cooking methods for their impact on kaempferol and quercetin levels: “Understanding cooking effects on flavonoids is crucial to accurately estimate their daily intake and further investigate their health benefits. The purpose of this study was not to compare different conditions of each cooking methods, but to focus on … Continue reading Microwave broccoli to increase flavonoid levels

A compelling review of epigenetic transgenerational inheritance

This 2020 review by coauthors of 2019’s A transgenerational view of the rise in obesity and Epigenetic transgenerational inheritance extends to the great-great-grand offspring summarized: “The prevalence of obesity and associated diseases has reached pandemic levels. Ancestral and direct exposures to environmental toxicants and altered nutrition have been shown to increase susceptibility for obesity and … Continue reading A compelling review of epigenetic transgenerational inheritance

A pair of broccoli sprout studies

This 2015 Oregon human study found: “Plasma and urinary levels of total SFN [sulforaphane] metabolites were ~3–5 times higher in sprout consumers compared to BSE [broccoli sprout extract] consumers. In sprout consumers, plasma concentrations were 2.4-fold higher after consuming the second dose than after the first dose. Calculated SFN bioavailability from broccoli sprouts exceeded 100%. … Continue reading A pair of broccoli sprout studies

Part 3 of Rejuvenation therapy and sulforaphane

Part 1 focused on the study’s clinical biomarkers. Part 2 highlighted its epigenetic clocks. Now we’ll look at rejuvenation of cognitive function. Charts for this study’s most relevant human aging applications – measured by the new human-rat relative biological age clock – were in supplementary data due to combining the study’s untreated tissue samples into … Continue reading Part 3 of Rejuvenation therapy and sulforaphane

A rejuvenation therapy and sulforaphane

The founder of the epigenetic clock methodology with the coauthor of Aging as an unintended consequence released a 2020 rodent study “Reversing age: dual species measurement of epigenetic age with a single clock” at https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.pdf: “We employed six clocks to investigate the rejuvenation effects of a plasma fraction treatment in different rat tissues. Two of … Continue reading A rejuvenation therapy and sulforaphane

Week 5 of Changing an inflammatory phenotype with broccoli sprouts

To follow up Week 4 of Changing an inflammatory phenotype with broccoli sprouts: 1. I didn’t get around to curating a 2019 Spanish review Sorting out the Value of Cruciferous Sprouts as Sources of Bioactive Compounds for Nutrition and Health. Some highlights: “Sprouts represent a valuable source of diverse micronutrients (vitamins, minerals, and amino acids), … Continue reading Week 5 of Changing an inflammatory phenotype with broccoli sprouts