Week 37 of Changing to a youthful phenotype with broccoli sprouts

1. Been wrong about a few things this past week:

A. I thought in Week 28 that extrapolating A rejuvenation therapy and sulforaphane results to humans would produce personal results by this week. An 8-day rat treatment period ≈ 258 human days, and 258 / 7 ≈ 37 weeks.

There are just too many unknowns to say why that didn’t happen. So I’ll patiently continue eating a clinically relevant 65.5 gram dose of microwaved broccoli sprouts twice every day.

PXL_20201015_105645362

The study’s lead researcher answered:

“Depends, it might take 37 weeks or more for some aspects of ‘youthening’ to become obvious. It might even take years for others.

Who really cares if you are growing younger every day?

For change at the epigenomic/cellular level to travel up the biological hierarchy from cells to organ systems seems to take time. But the process can be repeated indefinitely (so far as we know) so by the second rejuvenation you’re already starting at ‘young’. (That would be every eight to ten years I believe.)”

His framework is in An environmental signaling paradigm of aging.

B. I thought that adding 2% mustard seed powder to microwaved broccoli sprouts per Does sulforaphane reach the colon? would work. Maybe it would, maybe it wouldn’t, but my stomach and gut said that wasn’t for me.

C. I thought I could easily add Sprouting whole oats to my routine. I ran another trial Sprouting hulled oats using oat seeds from a different company and Degree of oat sprouting as a model.

2. Oat sprouts analysis paired studies were very informative, don’t you think? One study produced evidence over a range of germination parameters (hulled / dehulled seeds of two varieties, for 1-to-9 days, at 12-to-20°C). And evaluated what mix of germination parameters would simultaneously maximize four parameters (β-glucan, free phenolic compounds, protease activity and antioxidant capacity) while minimizing two (enzymes α-amylase and lipase). Then a follow-up study characterized oat seeds sprouted under these optimal conditions.

I doubted PubMed’s “oat sprout” 20 search results for research 1977 to the present. Don’t know why they didn’t pick up both of these 2020 studies, but I’m sure that .gov obvious hindrances to obtaining relevant information like this won’t be fixed. What other search terms won’t return adequate results?

3. The blog post readers viewed this week that I made even better was Do delusions have therapeutic value? from May 2019. Sometimes I’ve done good posts describing why papers are poorly researched.

4. I’ve often changed my Week 4 recipe for an AGE-less Chicken Vegetable Soup dinner (half) then the next day for lunch. The biggest change brought about by 33 weeks of behavioral contagion is that I now care more about whether vegetables are available than whether or not they’re organic. Coincidentally, I’ve developed a Costco addiction that may require intervention.

  • 1 lemon
  • 3 Roma tomatoes
  • 4 large carrots
  • 6 stalks organic celery
  • 6 mushrooms
  • 6 cloves garlic
  • 6 oz. organic chicken breast fillet
  • 1 cup organic pasta
  • 1 yellow squash, alternated with 1 zucchini
  • 1 cup sauvignon blanc
  • 32 oz. “unsalted” chicken broth, which still contains 24% of the sodium RDA

Pour wine into a 6-quart Instant Pot; cut and strain squeezed lemon; cut chicken into 1/4″ cubes and add; start mixture on Sauté. Wash and cut celery; wash and scrub carrots; stir pot at 4 minutes; stir in celery at 5 minutes.

Cut and stir in carrots. Wash mushrooms, slicing only if supersized. When pot boils around 10 minutes, add chicken broth and stir.

Wash and slice yellow squash / zucchini; crush and peel garlic but don’t slice. When pot boils again around 15 minutes, stir in pasta; turn off pot.

Add yellow squash / zucchini, mushrooms, garlic; wash and add whole tomatoes. Let set for 20 minutes; stir bottom-to-top 5 and 15 minutes after turning off, and again before serving.

AGE-less Chicken Vegetable Soup is tasty enough to not need seasoning, at least when freshly prepared.

7 thoughts on “Week 37 of Changing to a youthful phenotype with broccoli sprouts

  1. Hello,

    I am interested in what variety of sprouts you use as looking through research papers it is difficuly to get any information. The ones that are relatively high in Glucoraphanin and lower in negative chemicals sre the following
    Premium Crop
    Arcadia
    San MiguelGypsy
    Everest
    Patron
    Southern Comet
    Italian Green Sprouting
    However, when asking the variety that many sprouting companies sell the vast majority seem to offer Raab which basically has no glucoraphanin.
    If you were able to offer any further insights it would be gratefully appreciated.

    Regards,

    Timothy

    • Hi Mr. Alcock! Thanks for commenting.
      Vendors who sell broccoli seeds are missing a marketing opportunity by not advertising their variety and its sprout (not mature) characteristics. One day they will catch on.
      I’ve curated studies on broccoli cultivated varieties but haven’t bought any particular cultivar. Unless otherwise specified, seeds are expected to be treated with insecticides, fungicides, dyes or bulking agents.
      My latest purchase was a 5 lb can of “Organic Broccoli Sprouting Seeds by Handy Pantry” (True Leaf) for $90. The company is clueless about their own product and its benefits.
      Even so, I’ve documented good results from eating an unknown cultivar’s broccoli sprouts every day for 38 weeks now. A worst-case estimate is a daily 52 mg sulforaphane dose with microwaving 131 grams of 3-day-old broccoli sprouts ≤ 60°C (140°F).

      • Hi,

        Thanks for that. i have ordered some seeds from a company here in the UK who managed to ascertain the variety the purchased, however, a friend and i have seriously thought about getting a farmer to grow an acreage of broccoli for us if i can obtain the specific variety i am after.
        Keep up the good work, love the blog even if sometimes it goes over my head.

  2. Hi, one question. Have you checked your epigenetic Age in the meanwhile?
    That would be interresting.
    Dont be to shy to answer. 😏
    Awsame Blog by the way.
    Best regards
    Martin

    • Hi Martin! Thanks for commenting.
      No, I should, but I haven’t. I unofficially enrolled in Josh Mitteldorf’s DataBETA project, part of which would be measurements of epigenetic age. It just received internal review board approval!
      The study’s lead researcher’s answer was a comment in Josh Mitteldorf’s excellent blog post What to Look For in a Biological Clock where he said:
      “Methylation is just one among many epigenetic mechanisms, and the proteome is the net result of all of them. On this basis, I would lean toward a proteomic clock as being a more reliable surrogate for age in clinical experiments, even better than methylation clocks.
      Methylation clocks have a 6-year head start. Let’s see if proteomic clocks can catch up.”

      • Thanks for the reply,
        Have you observed any improvement in health or change in phenotype with other biomarkers or subjective perceptions? So I mean in the sense that the great effort you put in is worth it.
        I would also like to email you non-publicly, if possible.
        Best regards
        Martin

        • Hi Martin! Week 9 was an awakening. But now I’m in Week 41 of eating a clinically relevant amount of microwaved broccoli sprouts every day.
          I work in fast-paced software development with young and old people (who are all younger than me). I know my cognitive ability isn’t as good anymore as the twenty-somethings.
          It’s similar to the Barnes maze tests shown in Part 3 of Rejuvenation therapy and sulforaphane. Old treatment subjects learned and remembered much more than old untreated subjects, but not as much as young untreated subjects.
          All part of surfacing your real self.

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