A review of biological variability

This 2017 UK/Spanish review subject was biological variability: “No two cells in a cellular population are the same, and no two individuals of a multi-cellular species are identical—not even if they share the same genetic makeup like monozygotic twins or cloned animals. Epigenetic and gene expression variability are key contributors to phenotypic differences..There are many … Continue reading A review of biological variability

Are hormone ratios useful in explaining health? Behavior? Neurobiology? Anything?

This 2015 Zurich human review addressed: “A remarkable lack of discussion on the meaning and interpretation of frequently used hormone ratios. The interpretation of hormone ratios is complicated and in many cases not sufficiently supported from a theoretical point of view. Based on the assumption that the balance between two interdependent hormones determines their eventual … Continue reading Are hormone ratios useful in explaining health? Behavior? Neurobiology? Anything?

An interview with Dr. Rachel Yehuda on biological and conscious responses to stress

How Trauma and Resilience Cross Generations “The purpose of epigenetic changes, I think, is simply to increase the repertoire of possible responses. So let’s say, for some reason, your parents transmitted to you biologic changes that are very appropriate to starvation, but you don’t live in a culture where food is not plentiful. You’re just … Continue reading An interview with Dr. Rachel Yehuda on biological and conscious responses to stress

Using epigenetic DNA methylation markers to estimate biological age

I curated this 2015 Georgia human study only for its use of two methods of estimating biological age. The researchers misguidedly used these techniques to help paint a scientific patina on an agenda. One of the methods was originated by a coauthor of The degree of epigenetic DNA methylation may be used as a proxy … Continue reading Using epigenetic DNA methylation markers to estimate biological age

A study of biological aging in young adults with limited findings

This 2015 New Zealand human study used the same subjects of the More from the researchers that found people have the same personalities at age 26 that they had at age 3 study. The researchers used 10 biologic age markers of the subjects at age 38 to find that their biological ages ranged from 28 … Continue reading A study of biological aging in young adults with limited findings

RNA as a proxy signal for context-specific biological activity

This 2015 Harvard/MIT rodent study was of long (more than 200 nucleotides) noncoding (non-protein coding) RNAs (ribonucleic acids). These are of interest because: “Within the mammalian body, the largest repertoire and diversity of lncRNA genes outside the germ line occurs in the brain, where lncRNAs exhibit regional and cell-specific localization. The expression patterns of lncRNAs … Continue reading RNA as a proxy signal for context-specific biological activity

The degree of epigenetic DNA methylation may be used as a proxy to measure biological age

This fascinating 2014 human study developed the new use of a somewhat intuitive marker of aging. The researchers used the degree of methylation – an epigenetic chemical modification of the DNA molecule – as the epigenetic clock to measure biological age. The researchers found that, on average, the epigenetic age of the liver increased by … Continue reading The degree of epigenetic DNA methylation may be used as a proxy to measure biological age

A biologically relevant event can drive long-term memory in a single training session

This 2014 fruit fly study found: “A biologically relevant event such as finding food under starvation conditions or being poisoned can drive long-term memory in a single training session.” I don’t think that we need to discover at these extremes, though, whether or not the finding has human applicability. We do know from the Dutch … Continue reading A biologically relevant event can drive long-term memory in a single training session

The Not-Invented-Here syndrome

I have high expectations of natural science researchers. I assume that their studies will improve over time, and develop methods and experiments that produce reliable evidence to inform us of human conditions. My confidence is often unrealistic. Scientists are people, after all, and have the same foibles as the rest of us. I anticipate that … Continue reading The Not-Invented-Here syndrome

The epigenetic clock theory of aging

My 400th blog post curates a 2018 US/UK paper by two of the coauthors of Using an epigenetic clock to distinguish cellular aging from senescence. The authors reviewed the current state of epigenetic clock research, and proposed a new theory of aging: “The proposed epigenetic clock theory of ageing views biological ageing as an unintended … Continue reading The epigenetic clock theory of aging