Search Results for: mitochon

Take taurine for your mitochondria

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This 2021 review summarized taurine’s beneficial effects on mitochondrial function: “Taurine supplementation protects against pathologies associated with mitochondrial defects, such as aging, mitochondrial diseases, metabolic syndrome, cancer, cardiovascular diseases and neurological disorders. Potential mechanisms by which taurine exerts its antioxidant activity in maintaining mitochondria health include: Conjugates with uridine on mitochondrial tRNA to form a … Continue reading Take taurine for your mitochondria

Little evidence for mitochondrial DNA methylation

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This 2018 Japanese rodent study used three different techniques to detect mitochondrial DNA methylation: “Whilst 5-methylcytosine (5mC) is a major epigenetic mark in the nuclear DNA in mammals, whether or not mitochondrial DNA (mtDNA) receives 5mC modification remains controversial. We used bisulfite sequencing, McrBC digestion analyses and liquid chromatography mass spectrometry, which are distinctly differing … Continue reading Little evidence for mitochondrial DNA methylation

Mitochondria interface genetic/epigenetic responses to psychological stress

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This 2015 Pennsylvania rodent study found: “Mitochondria can regulate complex whole-body physiological responses, impacting stress perception at the cellular and organismal levels. Mitochondrial dysfunctions altered the hypothalamic–pituitary–adrenal [HPA] axis, sympathetic adrenal–medullary activation and catecholamine levels, the inflammatory cytokine IL-6, circulating metabolites, and hippocampal gene expression responses to stress. Stress-induced neuroendocrine, inflammatory, metabolic, and transcriptional responses … Continue reading Mitochondria interface genetic/epigenetic responses to psychological stress

Maintaining your myelin, Part 2

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Continuing Part 1 with three 2024 preprint studies, starting with an investigation of neuroinflammation in high school athletes: “Axons are long fibers conducting nerve impulses from nerve cells to synaptic ends. Like electric wires, axons are insulated by the myelin sheath produced by oligodendrocytes (ODC) in the brain or Schwann cells in the periphery. The … Continue reading Maintaining your myelin, Part 2

Maintaining your myelin, Part 1

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Three papers on myelin and oligodendrocytes, starting with a 2023 review: “Myelin is the spiral ensheathment of axons by a lipid and cholesterol-rich glial cell membrane that reduces capacitance and increases resistance of the axonal membrane. Axonal myelination speeds up nerve conduction velocity as a function of axon diameter. While myelination proceeds rapidly after birth … Continue reading Maintaining your myelin, Part 1

Eat broccoli sprouts to maintain your cells

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Two more papers cited Precondition your defenses with broccoli sprouts, starting with a 2024 review of broccoli compounds’ influences on autophagy and cellular function: “Promotion of autophagy has been related to lifespan expansion, tumor suppression, and maintenance of metabolic health. Alterations in this pathway have been related to human diseases or pathological states including neurodegenerative … Continue reading Eat broccoli sprouts to maintain your cells

Improving peroxisomal function

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A 2024 review provided details about “mysteries” in peroxisome research: “Peroxisomes are key metabolic organelles with essential functions in cellular lipid metabolism (e.g., β-oxidation of fatty acids and synthesis of ether phospholipids, which contribute to myelin sheath formation), and metabolism of reactive oxygen species (ROS), particularly hydrogen peroxide. Loss of peroxisomal function causes severe metabolic … Continue reading Improving peroxisomal function

Eat broccoli sprouts for your liver, Part 2

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A 2023 review cited Part 1 and caught up other relevant research on sulforaphane effects through early 2023: “A growing number of studies have reported that sulforaphane (SFN) could significantly ameliorate hepatic steatosis and prevent development of fatty liver, improve insulin sensitivity, attenuate oxidative damage and liver injury, induce apoptosis, and inhibit proliferation of hepatoma … Continue reading Eat broccoli sprouts for your liver, Part 2

Take acetyl-L-carnitine if you are healthy

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Eight 2023 acetyl-L-carnitine / L-carnitine papers, starting with three healthy human studies: “Thirty healthy volunteers aged between 19 and 52 years were divided randomly into two equal groups, one of which received 1000 mg of L-carnitine (LC) per day over a 12-week period. Total cholesterol and HDL-C increased significantly after supplementation. LC could be useful … Continue reading Take acetyl-L-carnitine if you are healthy

What you expect may not be what you find

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I’m halfway through a 90-day trial of plasmalogens coincident with improving peroxisomal function via resistance exercise and time-restricted eating. I haven’t curated related 2023 papers I’ve read concerning plasmalogens, peroxisomes, sphingolipids, ceramides, and mitochondrial interactions with these, mainly because I haven’t seen human-pertinent aspects similar to Dr. Goodenowe’s efforts. The 2023 papers I’ve read have … Continue reading What you expect may not be what you find

Plasmalogens, Part 3

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The 2022 plasmalogen clinical trial mentioned in Parts 1 and 2 bypassed peroxisome metabolism of cognitively impaired people per discussion of the below diagram: Increasing the body’s fasting state with time-restricted eating, and preventing muscle atrophy with resistance exercise, were offered as the two most important ways to improve peroxisomal function. I didn’t find any … Continue reading Plasmalogens, Part 3

Plasmalogens, Part 1

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The person who knows the most about this subject is Dayan Goodenowe, PhD. Some recent publications include: https://www.frontiersin.org/articles/10.3389/fcell.2022.864842/full “Targeted Plasmalogen Supplementation: Effects on Blood Plasmalogens, Oxidative Stress Biomarkers, Cognition, and Mobility in Cognitively Impaired Persons” https://www.frontiersin.org/articles/10.3389/fcell.2022.866156/full “Brain ethanolamine phospholipids, neuropathology and cognition: A comparative post-mortem analysis of structurally specific plasmalogen and phosphatidyl species” A sample … Continue reading Plasmalogens, Part 1

Bridging Nrf2 and autophagy

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Three more 2023 papers that cited Precondition your defenses with broccoli sprouts, starting with a review: “Examining crosstalk between Nrf2 antioxidant signaling and autophagy provides insights into how they are interconnected and proteins that mediate their communication. These factors are potential therapeutic targets for diseases with both autophagy dysfunction and oxidative stress. A working model … Continue reading Bridging Nrf2 and autophagy

Eat broccoli sprouts for your high intensity interval training

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This 2023 human study investigated broccoli sprouts and HIIT: “In the present study we applied a program of 7 consecutive days of exercise with High intensity interval training (HIIT) and twice daily administration of a glucosinolate rich sprout drink (GRS) or a placebo drink (PLA) in a double-blinded, placebo controlled, cross-over fashion. The intent was … Continue reading Eat broccoli sprouts for your high intensity interval training

Fructose and survival

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This 2023 paper provided mechanistic evidence, evolutionary theory, and testable scenarios for fructose metabolism differences from other nutrients: “The fructose survival hypothesis proposes that obesity and metabolic disorders may have developed from over-stimulation of an evolutionary-based biologic response (survival switch) that aims to protect animals in advance of crisis. The response is characterized by hunger, … Continue reading Fructose and survival