How to measure biological age?

As mentioned in Week 127, I had biological age measured earlier this month, and received five reports two days ago on Sunday. Part of the company’s process is to follow up their reports (intrinsic aging, immune aging, pace of aging, telomere length, weight loss) with a consulting session to review and interpret, which lasted an hour yesterday.

Part of our conversation revolved around comparing my measurements with other customers. These people are a different population than people usually sampled for aging and other biomarkers, because people who pay to get their biological age measured probably actionably want to improve it.

We’ll see which items I asked the consultant to pass on to the company produce responses, and which interfere with their business or they’re too busy to get back to me. I offered more than a half-dozen specifics, but held back on items I didn’t think the consultant would adequately communicate.

I didn’t argue with the consultant’s recommendations for quercetin supplementation (at 4% bioavailability?) as part of a treatment for senescence (not measured in any of the reports?). I didn’t offer to follow-up with studies demonstrating yeast cell wall β-glucan (new to the consultant) effects on immune report findings here in my 19th year of taking it every day.

I did argue with their recommendation to take DHEA-S. I changed my mind about taking it a year and a half ago, but left blog posts up such as Take responsibility for your one precious life – DHEA for evidence that I’m learning.

Epigenetic clocks per The epigenetic clock theory of aging generally view biological aging as “an unintended consequence of both developmental programmes and maintenance programmes, the molecular footprints of which give rise to DNAm [DNA methylation] age estimators.”

So what would be appropriate anti-aging actions for customers to take? Should customers try to emulate youthful biological markers, and supplement DHEA-S to impact serum levels of insulin-like growth factor 1?

I don’t think so. Our bodies never evolved feedback mechanisms to determine “Time to stop the growth programs, you’ve survived to reproduction age.” Older people achieving teenagers’ DHEA-S levels and activating IGF-1 pathways, pretty much guarantees further biological aging as “an unintended consequence of both developmental programmes and maintenance programmes.”

It’s too early to recommend these biological aging measurements. We’ll see where it goes.

One good thing is the company wants their customers to tell them everything about what they’re doing. I exercise at least a half hour every day, eat Avena nuda oats for breakfast and AGE-less chicken vegetable soup for dinner, and take the following:

Before breakfast
– 3-day-old microwaved broccoli / red cabbage / mustard sprouts started from 10.7 grams of seeds, with nothing else an hour before or after
– Yeast cell wall β-glucan (Glucan 300), 1500 mg, with nothing else an hour before or after

Breakfast, lunch, and dinner
– Hyaluronic acid, Nature’s Lab, 1 serving total
– Boron, Swanson Triple Boron Complex, 9 mg total

Breakfast and dinner
Acetyl-L-carnitine, 1 g total
– Balance oil, which blends linoleic acid 1400 mg with linolenic acid 350 mg, 2 times
– Betaine anhydrous, 3 g total
– Glucosamine hydroxychloride 1.5 g total, with chondroitin sulfate 1.2 g total
Taurine, 2 g total
– 3-day-old Avena sativa oat sprouts started from 20 g seeds, 2 times

Breakfast only
– Minerals and vitamins, RDA mainly, Kirkland Signature Daily Multi
– D3 25 mcg
– Calcium alpha-ketoglutarate 1 g

Lunch only
– Vitamin K2 MK-7 600 mcg

Dinner only
– D3 50 mcg
– Zinc monomethionine 30 mg with 0.3 mg copper
– Lutein 25 mg with 5 mg zeaxanthin



6 thoughts on “How to measure biological age?

  1. Sorry to bother you again. This will be my last question for at least a year. I notice you take Acetyl-L-Carnitine for depression/trauma i presume. Would you recommend this for someone who has had mild depression for about 20 years, turning into severe depression and anxiety for a period, then returning currently to mild depression. I do not take any antidepressants, as i am scared of the side effects. I mangage to keep a lid on it through daily meditation which has been a lifesaver in my relationship with my thoughts.

    • Hi Tim! Think the 2022 review Carnitine and Depression covers the subject well up through a year ago. It cites the meta-analysis in This dietary supplement is better for depression symptoms than placebo for “LAC supplementation, with the same effect as antidepressants, can significantly reduce depressive symptoms compared with placebo/no intervention.”
      The meta-analysis states “In these nine randomized controlled trials, the majority of the studies used 3 grams of ALC as intervention.” Also, “The incidence of adverse effects was significantly lower in the ALC group [79%] than in the antidepressant group.”
      I’ve taken one gram daily for about fifteen years primarily for its mitochondrial effects. Acetyl-L-carnitine supplementation may have cumulative beneficial effects that won’t be studied because there’s no money in finding out. A 500 mg capsule only costs 14 cents.

      • Hi,
        Do thanks for the reply I will try for a few months and see if I notice anything. Keep up the good work. Also just a quick question what is your opinion on the carnivore diet that seems to be popular at the moment. I know it can have benefits in the short term but long term surely we evolved to eat a variety of foods. That’s it now no more questions

        • Thanks Tim!
          I don’t know. I’ve never eaten anything close to an all-meat diet, and haven’t investigated it. I’m still not going to investigate a carnivore diet because:
          – Two years ago this month I started eating items primarily to make my gut microbiota happy, and I expect reciprocity from them. The preferred gut bacteria like resistant starches in beans, fermentable fibers in oats, and indigestible (to humans) sugars such as inulin.
          – Cooking is needed unless those diets prescribe raw meat. It’s much easier to get harmful AGEs and AGE precursors from cooked meat and sugars than it is from cooked vegetables. Even all-meat diet people in the National Geographic Alaska shows cook their meat.

    • Hi Tim! It’s 10.7 grams total. That was the average weight of one tablespoon seeds when I measured a long time ago.
      Sorry, I’m awake now. The initial measurements were with just broccoli seeds. Now I do 3.6 g broccoli, 3.6 red cabbage, and 3.5 g mustard seeds.

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