1. I’ve continued daily practices from Year Two with microwaved 3-day-old broccoli, red cabbage, and mustard sprouts for 13 times longer now than any sulforaphane clinical trial. The main difference over the past year is that I eat AGE-less chicken vegetable soup 3-4 times a week rather than twice a day. That was just too … Continue reading Year Three of Changing to a youthful phenotype with sprouts
This 2023 human cell study investigated sulforaphane’s effects on tuberculosis infections: “Basic research efforts on tuberculosis (TB) immunotherapy are currently only the tip of the iceberg. This study highlights the association between autophagy-related genes and immune infiltration in TB, an infectious pathogen that has been around for tens of thousands of years. Sulforaphane (SFN) is … Continue reading Eat broccoli sprouts to protect your lungs
Three papers on oat β-glucan’s effects in humans, starting with a 2023 study that compared different doses: “Two randomized, double-blind, controlled studies were conducted with asymptomatic subjects between 20 and 40 years of age, male or female, normal weight or overweight. In the first study – a crossover trial comprising two days of testing (β-glucan … Continue reading Oat β-glucan effects
As mentioned in Week 127, I had biological age measured earlier this month, and received five reports two days ago on Sunday. Part of the company’s process is to follow up their reports (intrinsic aging, immune aging, pace of aging, telomere length, weight loss) with a consulting session to review and interpret, which lasted an … Continue reading How to measure biological age?
Two papers on trained immunity, starting with a 2022 review: “Live attenuated vaccines such as the Bacillus Calmette–Guérin, measles-containing vaccines, and the oral polio vaccine have been shown to reduce overall mortality beyond their effects attributable to the targeted diseases. After an encounter with a primary stimulus, epigenetic and metabolic reprogramming of bone marrow progenitor … Continue reading Trained immunity epigenetics
Two oat species studies, starting with Avena nuda: “Oats are a good source of carbohydrates and fibers. They contain more proteins and fats than other grains, and they are packed with vitamins (vitamin E, thiamine, etc.), minerals (Ca, Fe, Mn, etc.), and antioxidants (avenanthramides, ferulic acid, caffeic acid, flavonoids, etc.). β-glucan contained in naked oats … Continue reading Oat product biological effects
This 2022 cell study investigated yeast cell wall β-glucan’s effects on angiogenesis: “Angiogenesis, the formation of new blood vessels, is essential for embryonic development and physiological damage repair, such as wound healing and post-ischemic tissue restoration. It is also essential for pathological processes, such as diabetic retinopathy, rheumatoid arthritis, and atherosclerosis. We evaluated physical and … Continue reading Take β-glucan for new blood vessels
1. I’ve eaten clinically-relevant doses of sulforaphane every day for 104 weeks now with microwaved 3-day-old broccoli, red cabbage, and mustard sprouts. That’s 8+ times longer than any sulforaphane clinical trial. I continue to: Eat Avena nuda oats for breakfast; Eat 3-day-old hulled Avena sativa oat sprouts twice a day; Eat AGE-less chicken vegetable soup … Continue reading Year Two of Changing to a youthful phenotype with sprouts
A 2022 McGill University rodent study couldn’t replicate Part 1 findings: “We find that using similar mouse models of trained immunity induced by: Live vaccination (BCG); PAMPs (β-glucan); or Infection (C. albicans), protection against: Viral (influenza virus); Bacterial (Mycobacterium tuberculosis (Mtb)); or Fungal (C. albicans) infections was the same between offspring of trained and non-trained … Continue reading Intergenerational epigenetic inheritance of trained immunity, Part 2
This 2021 paper reported results of two related human clinical trials: “Lean and prediabetic overweight/obese men were included in two randomized crossover studies. In one study, participants received supplements of either long-chain inulin+resistant starch (INU+RS), INU or maltodextrin (placebo, PLA) the day prior to a clinical investigation day. The second trial studied beta glucan+RS (BG+RS) … Continue reading Resistant starch, β-glucan, and inulin
This 2021 review by three coauthors of Take responsibility for your one precious life – Trained innate immunity cast a wide net: “Non-specific innate and antigen-specific adaptive immunological memories are vital evolutionary adaptations that confer long-lasting protection against a wide range of pathogens. However, these mechanisms of memory generation and maintenance are compromised as organisms … Continue reading Immune system aging
Two 2021 papers on glutathione interactions with β-glucan, with the first studying human cells from healthy donors: “(1→3)-β-D-Glucan stimulation induces epigenetic and transcriptomic changes in monocytes associated with increased glutathione (GSH) synthesis and metabolism. Intracellular glutathione levels were crucial in regulating several monocyte antifungal functions including resilience to oxidative stress, immunometabolism, nitric oxide production, phagocytosis, … Continue reading Glutathione primes β-glucan-trained immunity
This 2021 human cell study investigated trained immunity responses: “We integrated genetic, epigenetic, and functional validation data to shed light on regulation of trained immunity responses. This data integration revealed a novel role of SIGLECs and KDM4 genes on trained immunity responses. Siglec-5 is an inhibitory receptor that dampens the immune response, and was found … Continue reading Trained immunity genes
Twin 2021 in vitro studies of cruciferous sprout bioaccessibility, with the first addressing hydroxycinnamic acids and flavonols: “The present work studies effects of physicochemical and enzymatic characteristics of gastrointestinal digestion on two major groups of phenolic compounds – flavonols and cinnamoyl derivatives – on red radish, red cabbage, broccoli, and white mustard sprouts. Effects of … Continue reading Sprout bioaccessibility
Two 2021 papers on trained immunity, with the first a review: “Effective memory immune responses rely on interaction between innate and adaptive immune cells. While activation of innate immunity provides the first line of defense against infections, it also primes the adaptive immune response. Adaptive immunity can enhance antimicrobial machinery of innate cells, making them … Continue reading Remembering encounters provides future benefits
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