Reinforce your immune memory every day

Three papers on trained immunity, with the first a 2021 review: “Trained immunity is realized by epigenetic reprogramming of cells, primarily monocytes/macrophages and natural killer cells, and is less specific than adaptive immunity. It may cross-protect against other infectious agents. Various actions of trained innate immunity on precursor cells have a strong potential for therapeutic … Continue reading Reinforce your immune memory every day

Trained immunity mechanisms

This 2021 cell study investigated how inflammatory memory is established, maintained, and recalled: “Cells retain a memory of inflammation that equips them to react quickly and broadly to diverse secondary stimuli. Temporal, dynamic changes to chromatin accessibility, histone modifications, and transcription factor (TF) binding occur during inflammation, post-resolution, and in memory recall following injury. Epigenetic … Continue reading Trained immunity mechanisms

Choosing your gut immune response

This 2021 paper reviewed evidence for immune system effects associated with specific gut areas: “The intestinal immune system must not only contend with continuous exposure to food, commensal microbiota, and pathogens, but respond appropriately according to intestinal tissue differences. The entire intestine, inclusive of its lymph nodes, is considered a immunosuppressive organ overall compared to … Continue reading Choosing your gut immune response

Choosing appropriate dietary fibers

This 2021 rodent study investigated effects of dietary fibers on Type 2 diabetes: “Nine types of dietary fibers were used to investigate and evaluate their effects on type-2 diabetic rats via physiology, genomics, and metabolomics. In human clinical trials, supplementation with dietary fibers was found inversely associated with risks of diabetes, along with improvement on … Continue reading Choosing appropriate dietary fibers

Eat oats for β-glucan and resistant starch

This 2021 review highlighted effects of processing oat products: “Starch contents in oats ranges from 51% to 65%. Resistant starch (RS) accounts for 29.31% of starch content in raw granular form of oat starch. RS in raw oat starch is RS2 starch, where its slow digestion is mainly due to the compact nature of starch … Continue reading Eat oats for β-glucan and resistant starch

Part 3 of Make your gut microbiota happy

Continuing from Part 2, my 7/15/2021 sample found that no bad bacteria needed work. Top three reasons why this may be are: 1. I’ve eaten microwaved broccoli sprouts every day for 68 weeks now. Relevant research: Curated Eat broccoli sprouts instead of antibiotics back in May after adding red cabbage sprouts and mustard sprouts; and … Continue reading Part 3 of Make your gut microbiota happy

Fat-soluble vitamin competition

This 2015 rodent study investigated interactions of Vitamins A, D, E, and K: “Significant competitive interactions for uptake were elucidated among vitamin D, E and K, supporting the hypothesis of common absorption pathways: Vitamin A – Neither vitamin D nor K impacted vitamin A uptake. Vitamin E significantly improved vitamin A uptake at medium and … Continue reading Fat-soluble vitamin competition

Eat whole oats for your gut microbiota

Two papers on whole grains, with the first a 2021 review: “Whole grains are more complex than refined grains and are promoted as part of a healthy and sustainable diet, mainly because the contribution of indigestible carbohydrates, and their co-passenger nutrients, is significantly higher. Changing composition and availability of grain carbohydrates and phytochemicals during processing … Continue reading Eat whole oats for your gut microbiota

Eat broccoli sprouts for your hearing

Two 2021 papers, both of which I found by each citing a 2009 Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane (not freely available). First was a review: “Hair cell damage and loss mediated by oxidative stress are important causes of hearing loss. Sensorineural hearing loss is the … Continue reading Eat broccoli sprouts for your hearing

Eat mushrooms for a longer life?

Two papers, starting with a 2021 meta-analysis of mushroom intake: “Mushroom consumption was associated with a lower risk of total mortality in this nationally representative sample of US adults. 15,546 participants were included, mean age 44.3 years. During a mean follow-up duration of 19.5 years, a total of 5,826 deaths were documented. Participants who reported … Continue reading Eat mushrooms for a longer life?

Eat broccoli sprouts instead of antibiotics

This 2020 cell study investigated antibiotic effects of broccoli sprout compounds: “In this work, we asked whether isothiocyanates (ITCs) could act synergistically with each other to increase antibacterial effect. A set of aliphatic ITCs, such as iberin, iberverin, alyssin, erucin, sulforaphen, erysolin, and cheirolin was tested in combination with sulforaphane against E. coli. All tested … Continue reading Eat broccoli sprouts instead of antibiotics

Eat oats and regain cognitive normalcy

This 2020 rodent study investigated effects of different diets: “The present study aimed to evaluate effects of β-glucan on the microbiota gut-brain axis and cognitive function in an obese mouse model induced by a high-fat and fiber-deficient diet (HFFD). After long-term supplementation for 15 weeks, β-glucan prevented HFFD-induced cognitive impairment, assessed behaviorally by object location, novel … Continue reading Eat oats and regain cognitive normalcy

Pigs and glucosinolates

This 2020 porcine study subject was improving healthy aspects of canola-oil-processing by-products: “We hypothesized that inclusion of high-amylose cornstarch (HA-starch) in canola co-products-based diets for pigs can reduce hindgut pH, leading to increased degradation of glucosinolates present in hindgut of pigs into non-goitrogenic products. Most dietary myrosinases [enzymes] are inactivated by heat during cooking, pressing … Continue reading Pigs and glucosinolates

Let β-glucan train your brain

This 2021 rodent study investigated yeast cell wall β-glucan’s effects on the brain’s immune system: “Innate immune memory can manifest in two different ways, [1] immune training and [2] immune tolerance, which means [1] an enhanced or [2] suppressed immune response towards a secondary challenge. Lipopolysaccharide (LPS) and β-glucan (BG) are two commonly used ligands … Continue reading Let β-glucan train your brain

Oat β-glucan effects on colitis

This 2021 rodent study investigated oat β-glucan effects on colitis: “In this study, we determined effects of consumption of low- and high-molar-mass oat beta-glucans on expression of selected markers of apoptosis and autophagy in colonocytes in TNBS colitis-induced rats. We analyzed expression of colon wall receptors, including TLRs and Dectin-1, which are involved in recognition … Continue reading Oat β-glucan effects on colitis