Four 2023 papers that cited Part 1, starting with a review of hypothetical parameters for taurine clinical trials that aren’t going to happen because: Drug companies can’t make money from a research area that’s cheap, not patentable, and readily accessible. Government sponsors are likewise not incentivized to act in the public’s interest per their recent … Continue reading Taurine’s effects on healthspan and lifespan, Part 2
A 2023 human / primate / rodent / worm study with 56 coauthors exhaustively investigated taurine effects: “We measured the blood concentration of taurine during aging and investigated the effect of taurine supplementation on healthspan and lifespan in several species. In C57Bl/6J wild-type (WT) mice, serum taurine concentrations declined from 132.3 ± 14.2 ng/ml at … Continue reading Taurine’s effects on healthspan and lifespan
Finishing a week’s worth of 2022 taurine research with two reviews of taurine’s brain effects: “We provide a overview of brain taurine homeostasis, and review mechanisms by which taurine can afford neuroprotection in individuals with obesity and diabetes. Alterations to taurine homeostasis can impact a number of biological processes such as osmolarity control, calcium homeostasis, … Continue reading Taurine week #7: Brain
Two 2022 rodent studies of taurine’s associations with long-term stress, starting with a chronic restraint stress model: “We show that chronic restraint stress can lead to hyperalgesia accompanied by changes in gut microbiota that have significant gender differences. Corresponding changes of bacteria can further induce hyperalgesia and affect different serum metabolism in mice of the … Continue reading Taurine week #6: Stress
Two 2022 papers investigated taurine’s effects in blood, starting with a review of platelets: “Taurine is the most abundant free amino acid in the human body, with a six times higher concentration in platelets than any other amino acid. It is highly beneficial for the organism, has many therapeutic actions, and is currently approved for … Continue reading Taurine week #5: Blood
Two 2022 papers investigated taurine and skeletal muscles, starting with a rodent study of endurance exercise: “This study examined effects of taurine on dynamics of blood glucose concentration (BGC) during endurance exercise in rats. Blood was collected every 10 min from the jugular vein via cannulation. Exercise period was divided by every 40 min into … Continue reading Taurine week #4: Muscles
Three 2022 papers investigated taurine’s effects on organs, starting with a rodent study of sepsis: “Sepsis usually causes multiple organ dysfunctions and high mortality. Pathogenesis of sepsis is thought to be driven by hyperactive inflammation following pathogen invasion. If the immune system fails to eradicate pathogens, immune homeostasis is disturbed, leading to an overwhelming inflammation … Continue reading Taurine week #3: Organs
Two papers investigated taurine’s integration into bile acids, starting with a review: “Bile acids (BAs) are produced from cholesterol in the liver and are termed primary BAs. Primary BAs are conjugated with glycine and taurine in the liver, and stored in the gallbladder. BAs are released from the gallbladder into the small intestine via food … Continue reading Taurine week #2: Bile acids
It’s been a while since I curated taurine research. Read at least a week’s worth of 2022 papers last weekend. Let’s start with two studies that didn’t supplement with taurine, but found it was a biomarker. The first was a rodent study that treated a high fat diet with blood pressure medicine: “Non-alcoholic fatty liver … Continue reading Taurine week #1: Biomarkers
This densely packed 2021 review subject was taurine: “Taurine (Tau), a sulphur-containing non-proteinogenic β-amino acid, has a special place as an important natural modulator of antioxidant defence networks: Direct antioxidant effect of Tau due to scavenging free radicals is limited, and could be expected only in a few tissues (heart and eye) with comparatively high … Continue reading Defend yourself with taurine
This 2021 review summarized taurine’s beneficial effects on mitochondrial function: “Taurine supplementation protects against pathologies associated with mitochondrial defects, such as aging, mitochondrial diseases, metabolic syndrome, cancer, cardiovascular diseases and neurological disorders. Potential mechanisms by which taurine exerts its antioxidant activity in maintaining mitochondria health include: Conjugates with uridine on mitochondrial tRNA to form a … Continue reading Take taurine for your mitochondria
This 2021 rodent study investigated taurine effects on colitis: “Taurine plays an important role in various essential biological processes. Health beneficial effects of taurine have been generally attributable to its antioxidant and anti-inflammatory effects. Taurine chloramine (TauCl) is an endogenous anti-inflammatory substance derived from taurine. In fighting exogenous pathogens, neutrophils utilize one powerful weapon in … Continue reading Go for the win-win with taurine
This 2021 rodent study found: “We show that gut microbiota from previously infected hosts display enhanced resistance to infection. This long-term functional remodeling is associated with altered bile acid metabolism leading to expansion of taxa that utilize taurine. Supplying exogenous taurine alone is sufficient to induce this alteration in microbiota function and enhance resistance. Taurine … Continue reading Train your gut microbiota with taurine
A free educational series recorded in 2021-2022 available at https://drgoodenowe.com/dr-goodenowes-educational-seminars/ takes the viewer through underlying research and principles of Dr. Goodenowe’s approach to health. It’s advertised as lasting four hours, but took me two days to view. The series’ discussions and references are background material to better understand later presentations and interviews. Points of interest … Continue reading A good activity for bad weather days
1. I started eating 3-day-old microwaved Sango red radish sprouts ten weeks ago, but stopped two weeks ago due to stomach irritation. Earlier this year I tried them for a week using a different microwaving method, and found their glucoraphasatin pungency too much to stomach. A technique of putting red radish sprouts in a bowl … Continue reading Week 189 of Changing to a healthy phenotype with sprouts
Surface Your Real Self 