The function of the dorsal ACC is to monitor pain in survival contexts

This 2015 California human study was of the dorsal anterior cingulate cortex (dACC): “No neural region has been associated with more conflicting accounts of its function than the dACC. The best psychological description of dACC function was related to pain processing—not executive, conflict, or salience processing. We conclude by considering that physical pain may be … Continue reading The function of the dorsal ACC is to monitor pain in survival contexts

The arrogance of a paradigm exceeding its evidence

This 2018 commentary from the American College of Emergency Physicians by 7 physicians discussed the harm that will result from imposing a mandatory paradigm of sepsis treatment. I’ll quote sections that mention evidence: “These metrics [for pneumonia treatment] had little evidentiary basis but led to an institutional-fostered culture of overdiagnosis and overtreatment. Have we learned … Continue reading The arrogance of a paradigm exceeding its evidence

Restoration of a “normal” epigenetic landscape

This 2018 Texas human review subject was prostate cancer epigenetics: “We comprehensively review the up-to-date roles of epigenetics in the development and progression of prostate cancer. We especially focus on three epigenetic mechanisms: DNA methylation, histone modifications, and noncoding RNAs. We elaborate on current models/theories that explain the necessity of these epigenetic programs in driving … Continue reading Restoration of a “normal” epigenetic landscape

Epigenetic effects of breast cancer treatments

This 2018 UC San Diego review subject was the interplay between breast cancer treatments and their effects on aging: “Although current breast cancer treatments are largely successful in producing cancer remission and extending lifespan, there is concern that these treatments may have long lasting detrimental effects on cancer survivors, in part, through their impact on … Continue reading Epigenetic effects of breast cancer treatments

A trio of epigenetic clock studies

The first 2018 epigenetic clock human study was from Finland: “We evaluated the association between maternal antenatal depression and a novel biomarker of aging at birth, namely epigenetic gestational age (GA) based on fetal cord blood methylation data. We also examined whether this biomarker prospectively predicts and mediates maternal effects on early childhood psychiatric problems. … Continue reading A trio of epigenetic clock studies

Are there epigenetic causes for sexual orientation and gender identity?

This US 2018 review lead author was a gynecologic oncologist in private practice: “Sexual orientation is biologically conferred in the first trimester of pregnancy. Gender identity is biologically conferred during the middle trimester of pregnancy. Since the genitals differentiate in the first trimester, and the brain becomes imprinted in the latter half of gestation, it … Continue reading Are there epigenetic causes for sexual orientation and gender identity?

Cell senescence and DNA methylation

This 2018 Baltimore cell study found: “Based on similarities in overall methylation patterns in replicative senescence and cancers, it is hypothesized that tumor-promoting DNA methylation in cancers derives from cells escaping senescence. We show that the tumor-associated methylation changes evolve independently of senescence and are pro-survival events with functional implications contrasting that in senescence. In … Continue reading Cell senescence and DNA methylation

An emotional center of our brains

This 2018 McGill/UC San Diego rodent study subject was the dentate gyrus area of the hippocampus: “Early life experience influences stress reactivity and mental health through effects on cognitive-emotional functions that are, in part, linked to gene expression in the dorsal and ventral hippocampus. The hippocampal dentate gyrus (DG) is a major site for experience-dependent … Continue reading An emotional center of our brains

Science and technology hijacked by woo

I’m an avid reader of science articles, abstracts, studies, and reviews. I tried a free subscription to Singularity Hub for a few weeks last month because it seemed to be a suitable source of articles on both science and technology. I unsubscribed after being disappointed by aspects of science and technology hijacked almost on a … Continue reading Science and technology hijacked by woo

How to cure the ultimate causes of migraines?

Most of the spam I get on this blog comes in as ersatz comments on The hypothalamus couples with the brainstem to cause migraines. I don’t know what it is about the post that attracts internet bots. The unwanted attention is too bad because the post represents a good personal illustration of “changes in the … Continue reading How to cure the ultimate causes of migraines?