The function of the dorsal ACC is to monitor pain in survival contexts

This 2015 California human study was of the dorsal anterior cingulate cortex (dACC): “No neural region has been associated with more conflicting accounts of its function than the dACC. The best psychological description of dACC function was related to pain processing—not executive, conflict, or salience processing. We conclude by considering that physical pain may be … Continue reading The function of the dorsal ACC is to monitor pain in survival contexts

Uses of the lymphocytes to monocytes ratio

To follow up a presentation topic of Part 2 of Reversal of aging and immunosenescent trends with sulforaphane, here are a few papers no earlier than 2015 that address the ratio of lymphocytes to monocytes (LMR), or its reciprocal MLR. Because inquiring minds want to know. 🙂 Monocyte heterogeneity and functions in cancer “The ratio … Continue reading Uses of the lymphocytes to monocytes ratio

If people don’t stand up for their rights, their rights will be forgotten

YouTube took down this interview and a follow-on interview It was known to everybody that the lockdown would cause a catastrophe. Here’s an interview last week with a German epidemiologist, Professor Wittkowski, who isn’t on a government payroll: “First of all the elderly and fragile should be separated from the population where the virus is … Continue reading If people don’t stand up for their rights, their rights will be forgotten

Humans individually evolve by..?

This 2020 UK evolutionary biology article was part of a “Fifty years of the Price equation” issue: “Genetic and non-genetic inheritance usually produce a phenotype [the composite of an organism’s characteristics, including its developmental, biophysical, and behavioral traits] through a highly complex developmental process that also relies on many features of the world over which … Continue reading Humans individually evolve by..?

An evolutionary view of transgenerational epigenetic inheritance

This 2020 Swiss/German review mainly cited weed, worm, and yeast studies: “RNA interference-related mechanisms can mediate the deposition and transgenerational inheritance of specific chromatin modifications in a truly epigenetic fashion. Epigenetics was initially defined as any heritable change in gene expression patterns without changes in the DNA sequence. Now, epigenetic phenomena are often characterized as … Continue reading An evolutionary view of transgenerational epigenetic inheritance

Masters of manipulating their host

This 2020 French review subject was parasitical influences on host epigenetic processes: “Parasites have become masters of manipulating their host cells, exploiting signaling, and metabolic pathways to hijack host gene expression to their own advantage. These intracellular parasites have developed a wide range of strategies that affect transcriptional machineries and epigenetic events in the host … Continue reading Masters of manipulating their host

Trained immunity responses to bacterial infections

This 2019 Swiss rodent study investigated immune responses to five types of bacterial infections: “The innate immune system recalls a challenge to adapt to a secondary challenge, a phenomenon called trained immunity. Trained immunity protected mice from a large panel of clinically relevant bacterial pathogens inoculated systematically and locally to induce peritonitis, enteritis and pneumonia. … Continue reading Trained immunity responses to bacterial infections

Organismal aging and cellular senescence

I’ll curate this 2019 German review through its figures: “With the discovery of beneficial aspects of cellular senescence and evidence of senescence being not limited to replicative cellular states, a redefinition of our comprehension of aging and senescence appears scientifically overdue. Figure 1. Current determinants and relevant open questions, marking the processes of aging and … Continue reading Organismal aging and cellular senescence

Preliminary findings from a senolytics clinical trial

This 2019 US human clinical trial reported preliminary results. See Reanalysis of findings from a senolytics clinical trial for changes. “Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases. Senolytics, including the combination of Dasatinib and Quercetin … Continue reading Preliminary findings from a senolytics clinical trial

Caloric restriction’s epigenetic effects

This 2019 US review subject was caloric restriction (CR) without malnutrition: “Cellular adaptation that occurs in response to dietary patterns can be explained by alterations in epigenetic mechanisms such as DNA methylation, histone modifications, and microRNA. Epigenetic reprogramming of the underlying chronic low-grade inflammation by CR can lead to immuno-metabolic adaptations that enhance quality of … Continue reading Caloric restriction’s epigenetic effects