The function of the dorsal ACC is to monitor pain in survival contexts

This 2015 California human study was of the dorsal anterior cingulate cortex (dACC): “No neural region has been associated with more conflicting accounts of its function than the dACC. The best psychological description of dACC function was related to pain processing—not executive, conflict, or salience processing. We conclude by considering that physical pain may be … Continue reading The function of the dorsal ACC is to monitor pain in survival contexts

Eat broccoli sprouts for pain?

This 2018 study investigated pain-relieving effects of two broccoli sprout compounds, sulforaphane and chlorogenic acid: “Pharmacological evidence of the antinociceptive properties of broccoli aqueous extracts and bioactive metabolites were investigated in an experimental model of pain. It was found that sprouts produced better antinociceptive response than seeds and inflorescence of broccoli, where SFN [sulforaphane] and … Continue reading Eat broccoli sprouts for pain?

Nano-sulforaphane vs. barbecue chemicals

This 2020 chicken study investigated the capability of nano-sulforaphane to protect embryonic survival and neurogenesis from a barbecued meat chemical: “Common teratogenic [of, relating to, or causing malformations of an embryo or a fetus] factors related to the development of the nervous system, such as alcohol consumption and smoking, have attracted wide attention. Teratogenic factors … Continue reading Nano-sulforaphane vs. barbecue chemicals

Rub some broccoli sprouts on it

This 2020 human/rodent study investigated treating and preventing skin photodamage with sulforaphane: “Alterations in NRF2 signaling have been implicated in aging and stress-induced skin pigmentation disorders in the skin and hair follicles. NRF2 signaling regulates transcriptional programs involved in adaption and survival of cells in the setting of oxidative stress, and oxidative stress occurs in … Continue reading Rub some broccoli sprouts on it

Take responsibility for your one precious life – DHEA

This 2020 meta-analysis subject was DHEA: “Twenty-four qualified trials were included in this meta-analysis. Statistically significant increases in serum IGF-1 levels were found only in participants who were: Women; or Supplementing 50 mg/d; or Undergoing intervention for > 12 weeks; or Without an underlying comorbidity; or Over the age of 60 years. DHEA supplementation led … Continue reading Take responsibility for your one precious life – DHEA

Get serious about advanced glycation end products (AGEs)

Ever heard about AGEs? Here are three papers that describe how AGEs affect humans. First is a 2020 Italian review Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System: “Neurodegenerative disease is an umbrella term for different conditions which primarily affect the neurons in the human brain. Currently, … Continue reading Get serious about advanced glycation end products (AGEs)

A cherry-picked DNA methylation study

This 2020 US/Sweden/Denmark human study measured twins during their old age: “We evaluate individual differences in DNA methylation at individual CpG sites across the methylome across 10 years in two Scandinavian samples of same‐sex aging twins. We test two competing hypotheses about the longitudinal stability and change in DNA methylation: The contribution of genetic influences … Continue reading A cherry-picked DNA methylation study

Sulforaphane and RNAs

This 2020 Texas review subject was long non-coding RNAs: “We review the emerging significance of long non-coding RNAs (lncRNA) as downstream targets and upstream regulators of the Nrf2 signaling pathway, a critical mediator of diverse cellular processes linked to increased cell survival. It is believed that more than 3% of human genes are regulated by … Continue reading Sulforaphane and RNAs

Uses of the lymphocytes to monocytes ratio

To follow up a presentation topic of Part 2 of Reversal of aging and immunosenescent trends with sulforaphane, here are a few papers no earlier than 2015 that address the ratio of lymphocytes to monocytes (LMR), or its reciprocal MLR. Because inquiring minds want to know. 🙂 Monocyte heterogeneity and functions in cancer “The ratio … Continue reading Uses of the lymphocytes to monocytes ratio

If people don’t stand up for their rights, their rights will be forgotten

YouTube took down this interview and a follow-on interview It was known to everybody that the lockdown would cause a catastrophe. Here’s an interview last week with a German epidemiologist, Professor Wittkowski, who isn’t on a government payroll: “First of all the elderly and fragile should be separated from the population where the virus is … Continue reading If people don’t stand up for their rights, their rights will be forgotten

Humans individually evolve by..?

This 2020 UK evolutionary biology article was part of a “Fifty years of the Price equation” issue: “Genetic and non-genetic inheritance usually produce a phenotype [the composite of an organism’s characteristics, including its developmental, biophysical, and behavioral traits] through a highly complex developmental process that also relies on many features of the world over which … Continue reading Humans individually evolve by..?

An evolutionary view of transgenerational epigenetic inheritance

This 2020 Swiss/German review mainly cited weed, worm, and yeast studies: “RNA interference-related mechanisms can mediate the deposition and transgenerational inheritance of specific chromatin modifications in a truly epigenetic fashion. Epigenetics was initially defined as any heritable change in gene expression patterns without changes in the DNA sequence. Now, epigenetic phenomena are often characterized as … Continue reading An evolutionary view of transgenerational epigenetic inheritance

Masters of manipulating their host

This 2020 French review subject was parasitical influences on host epigenetic processes: “Parasites have become masters of manipulating their host cells, exploiting signaling, and metabolic pathways to hijack host gene expression to their own advantage. These intracellular parasites have developed a wide range of strategies that affect transcriptional machineries and epigenetic events in the host … Continue reading Masters of manipulating their host

Trained immunity responses to bacterial infections

This 2019 Swiss rodent study investigated immune responses to five types of bacterial infections: “The innate immune system recalls a challenge to adapt to a secondary challenge, a phenomenon called trained immunity. Trained immunity protected mice from a large panel of clinically relevant bacterial pathogens inoculated systematically and locally to induce peritonitis, enteritis and pneumonia. … Continue reading Trained immunity responses to bacterial infections

Organismal aging and cellular senescence

I’ll curate this 2019 German review through its figures: “With the discovery of beneficial aspects of cellular senescence and evidence of senescence being not limited to replicative cellular states, a redefinition of our comprehension of aging and senescence appears scientifically overdue. Figure 1. Current determinants and relevant open questions, marking the processes of aging and … Continue reading Organismal aging and cellular senescence