Search Results for: acetyl-L-carnitine

Take acetyl-L-carnitine for early-life trauma

gettingwell4 2-3 stars Required further work, Amygdala, Brain development, Brain hemispheres, Cerebrum, Dopamine, Epigenetics, Glutamate, Hippocampus, Hypothalamus, Limbic system, Memory, Neurochemicals, Oxytocin, Primal Therapy, Serotonin, Stress , , , , , , , ,

This 2021 rodent study traumatized female mice during their last 20% of pregnancy, with effects that included: Prenatally stressed pups raised by stressed mothers had normal cognitive function, but depressive-like behavior and social impairment; Prenatally stressed pups raised by control mothers did not reverse behavioral deficits; and Control pups raised by stressed mothers displayed prenatally … Continue reading Take acetyl-L-carnitine for early-life trauma

How to measure biological age?

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As mentioned in Week 127, I had biological age measured earlier this month, and received five reports two days ago on Sunday. Part of the company’s process is to follow up their reports (intrinsic aging, immune aging, pace of aging, telomere length, weight loss) with a consulting session to review and interpret, which lasted an … Continue reading How to measure biological age?

Taurine week #4: Muscles

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Two 2022 papers investigated taurine and skeletal muscles, starting with a rodent study of endurance exercise: “This study examined effects of taurine on dynamics of blood glucose concentration (BGC) during endurance exercise in rats. Blood was collected every 10 min from the jugular vein via cannulation. Exercise period was divided by every 40 min into … Continue reading Taurine week #4: Muscles

Dementia blood factors

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This 2021 human study performed blood metabolite analyses: “Dementia is a collective term to describe various symptoms of cognitive impairment in a condition in which intelligence is irreversibly diminished due to acquired organic disorders of the brain, characterized by deterioration of memory, thinking, behavior, and the ability to perform daily activities. In this study, we … Continue reading Dementia blood factors

Broccoli sprouts activate the AMPK pathway

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I’ll curate this 2020 rodent study through its summary graphic and caption: “Type 2 diabetes exhibits elevated levels of circulating fatty acids and CD36. This results in excessive fatty acids binding with CD36 to suppress AMPK [adenosine 5′ monophosphate-activated protein kinase, a key player in regulating energy metabolism]. Inactivation of AMPK breaks homeostasis in lipid … Continue reading Broccoli sprouts activate the AMPK pathway

A case for carnitine supplementation

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This 2020 review subject was carnitine, acetyl-L-carnitine, and its other molecular forms: “Carnitine is necessary to deliver long-chain fatty acids from cytosol into mitochondria. Carnitine homeostasis is maintained by diet and renal absorption, as only a small amount (about 25%) is obtained by endogenous biosynthesis. Defective fatty acid oxidation occurs with reduced intracellular levels of … Continue reading A case for carnitine supplementation

Treating psychopathological symptoms will somehow resolve causes?

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This 2020 Swiss review subject was potential glutathione therapies for stress: “We examine available data supporting a role for GSH levels and antioxidant function in the brain in relation to anxiety and stress-related psychopathologies. Several promising compounds could raise GSH levels in the brain by either increasing availability of its precursors or expression of GSH-regulating … Continue reading Treating psychopathological symptoms will somehow resolve causes?

Broccoli sprout synergies

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I was asked for examples of broccoli sprout synergies with supplements mentioned in Week 19 of Changing to a youthful phenotype with broccoli sprouts. I take supplements and broccoli sprouts together an hour or two before meals to keep meal contents from lowering sulforaphane bioavailability. Sulforaphane peaks in plasma between 1 and 2 hours after … Continue reading Broccoli sprout synergies

Day 70 results from Changing to a youthful phenotype with broccoli sprouts

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Here are my Day 70 measurements* to follow up Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts, which had these findings: Keep in mind that I’m not in the population represented by the clinical trial sample: My chronological age is above their inclusion range; My BMI is below their inclusion … Continue reading Day 70 results from Changing to a youthful phenotype with broccoli sprouts

Too cheap for clinical trials

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Let’s compare and contrast a 2019 meta-analysis and a 2017 review of using acetyl-L-carnitine to treat diabetic neuropathy. A 2019 Brazilian meta-analysis Acetyl‐L‐carnitine for the treatment of diabetic peripheral neuropathy of four previous trials stated: “The risk of bias was high in both trials of different ALC doses and low in the other two trials. … Continue reading Too cheap for clinical trials

A dietary supplement that reversed age-related hearing problems in the brainstem

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This 2018 Nevada rodent study was on acetyl-L-carnitine’s action in the brainstem: “We examined age-related changes in the efficiency of synaptic transmission at the calyx of Held, from juvenile adults (1-month old) and late middle-age (18- to 21-month old) mice. The calyx of Held synapse has been exploited as a model for understanding excitation-secretion coupling … Continue reading A dietary supplement that reversed age-related hearing problems in the brainstem

This dietary supplement is better for depression symptoms than placebo

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This 2018 Italy/UK meta-analysis subject was the use of dietary supplement acetyl-L-carnitine to treat depression symptoms: “Deficiency of acetyl-L-carnitine (ALC) appears to play a role in the risk of developing depression, indicating dysregulation of fatty acids transport across the inner membrane of mitochondria. However, the data regarding ALC supplementation in humans are limited. We thus … Continue reading This dietary supplement is better for depression symptoms than placebo

A gaping hole in a review of nutritional psychiatry

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This December 2016 Australian review published in September 2017 concerned: “..the nutritional psychiatry field..the neurobiological mechanisms likely modulated by diet, the use of dietary and nutraceutical interventions in mental disorders, and recommendations for further research.” The reviewers inexplicably omitted acetyl-L-carnitine, which I first covered in A common dietary supplement that has rapid and lasting antidepressant … Continue reading A gaping hole in a review of nutritional psychiatry

Familiar stress opens up an epigenetic window of neural plasticity

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This 2015 Italian rodent study found: “There is a window of plasticity that allows familiar and novel experiences to alter anxiety– and depressive-like behaviors, reflected also in electrophysiological changes in the dentate gyrus (DG). A consistent biomarker of mood-related behaviors in DG is reduced type 2 metabotropic glutamate (mGlu2), which regulates the release of glutamate. … Continue reading Familiar stress opens up an epigenetic window of neural plasticity

A common dietary supplement that has rapid and lasting antidepressant effects

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This 2012 Italian rodent study found that a common dietary supplement had rapid and lasting antidepressant effects: “Remarkably, L-acetylcarnitine displayed a clear-cut antidepressant effect already after 3 and 7 d[ays] of daily dosing. No tolerance was developed to the action of L-acetylcarnitine. The drug was even more effective after 21 d[ays], and the effect persisted for … Continue reading A common dietary supplement that has rapid and lasting antidepressant effects