Eight 2023 acetyl-L-carnitine / L-carnitine papers, starting with three healthy human studies: “Thirty healthy volunteers aged between 19 and 52 years were divided randomly into two equal groups, one of which received 1000 mg of L-carnitine (LC) per day over a 12-week period. Total cholesterol and HDL-C increased significantly after supplementation. LC could be useful … Continue reading Take acetyl-L-carnitine if you are healthy
Haven’t curated acetyl-L-carnitine papers recently. Here are three 2023 studies, beginning with a human case report: “It is believed that 75% of the required amount of carnitine is taken from diet and the remaining 25% is synthesized in the body. Long-term use of a carnitine-free diet is thought to increase the risk of carnitine deficiency. … Continue reading Acetyl-L-carnitine dosing
This 2021 rodent study traumatized female mice during their last 20% of pregnancy, with effects that included: Prenatally stressed pups raised by stressed mothers had normal cognitive function, but depressive-like behavior and social impairment; Prenatally stressed pups raised by control mothers did not reverse behavioral deficits; and Control pups raised by stressed mothers displayed prenatally … Continue reading Take acetyl-L-carnitine for early-life trauma
1. I started eating 3-day-old microwaved Sango red radish sprouts ten weeks ago, but stopped two weeks ago due to stomach irritation. Earlier this year I tried them for a week using a different microwaving method, and found their glucoraphasatin pungency too much to stomach. A technique of putting red radish sprouts in a bowl … Continue reading Week 189 of Changing to a healthy phenotype with sprouts
As mentioned in Week 127, I had biological age measured earlier this month, and received five reports two days ago on Sunday. Part of the company’s process is to follow up their reports (intrinsic aging, immune aging, pace of aging, telomere length, weight loss) with a consulting session to review and interpret, which lasted an … Continue reading How to measure biological age?
Two 2022 papers investigated taurine and skeletal muscles, starting with a rodent study of endurance exercise: “This study examined effects of taurine on dynamics of blood glucose concentration (BGC) during endurance exercise in rats. Blood was collected every 10 min from the jugular vein via cannulation. Exercise period was divided by every 40 min into … Continue reading Taurine week #4: Muscles
This 2021 human study performed blood metabolite analyses: “Dementia is a collective term to describe various symptoms of cognitive impairment in a condition in which intelligence is irreversibly diminished due to acquired organic disorders of the brain, characterized by deterioration of memory, thinking, behavior, and the ability to perform daily activities. In this study, we … Continue reading Dementia blood factors
I’ll curate this 2020 rodent study through its summary graphic and caption: “Type 2 diabetes exhibits elevated levels of circulating fatty acids and CD36. This results in excessive fatty acids binding with CD36 to suppress AMPK [adenosine 5′ monophosphate-activated protein kinase, a key player in regulating energy metabolism]. Inactivation of AMPK breaks homeostasis in lipid … Continue reading Broccoli sprouts activate the AMPK pathway
This 2020 review subject was carnitine, acetyl-L-carnitine, and its other molecular forms: “Carnitine is necessary to deliver long-chain fatty acids from cytosol into mitochondria. Carnitine homeostasis is maintained by diet and renal absorption, as only a small amount (about 25%) is obtained by endogenous biosynthesis. Defective fatty acid oxidation occurs with reduced intracellular levels of … Continue reading A case for carnitine supplementation
This 2020 Swiss review subject was potential glutathione therapies for stress: “We examine available data supporting a role for GSH levels and antioxidant function in the brain in relation to anxiety and stress-related psychopathologies. Several promising compounds could raise brain GSH levels by either increasing availability of its precursors, or expression of GSH-regulating enzymes through … Continue reading Treating psychopathological symptoms will somehow resolve causes?
I was asked for examples of broccoli sprout synergies with supplements mentioned in Week 19 of Changing to a youthful phenotype with broccoli sprouts. I take supplements and broccoli sprouts together an hour or two before meals to keep meal contents from lowering sulforaphane bioavailability. Sulforaphane peaks in plasma between 1 and 2 hours after … Continue reading Broccoli sprout synergies
Here are my Day 70 measurements* to follow up Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts, which had these findings: Keep in mind that I’m not in the population represented by the clinical trial sample: My chronological age is above their inclusion range; My BMI is below their inclusion … Continue reading Day 70 results from Changing to a youthful phenotype with broccoli sprouts
Let’s compare and contrast a 2019 meta-analysis and a 2017 review of using acetyl-L-carnitine to treat diabetic neuropathy. A 2019 Brazilian meta-analysis Acetyl‐L‐carnitine for the treatment of diabetic peripheral neuropathy of four previous trials stated: “The risk of bias was high in both trials of different ALC doses and low in the other two trials. … Continue reading Too cheap for clinical trials
This 2018 Nevada rodent study was on acetyl-L-carnitine’s action in the brainstem: “We examined age-related changes in the efficiency of synaptic transmission at the calyx of Held, from juvenile adults (1-month old) and late middle-age (18- to 21-month old) mice. The calyx of Held synapse has been exploited as a model for understanding excitation-secretion coupling … Continue reading A dietary supplement that reversed age-related hearing problems in the brainstem
This 2018 Italy/UK meta-analysis subject was the use of dietary supplement acetyl-L-carnitine to treat depression symptoms: “Deficiency of acetyl-L-carnitine (ALC) appears to play a role in the risk of developing depression, indicating dysregulation of fatty acids transport across the inner membrane of mitochondria. However, the data regarding ALC supplementation in humans are limited. We thus … Continue reading This dietary supplement is better for depression symptoms than placebo
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