Search Results for: glutathione

Glutathione primes β-glucan-trained immunity

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Two 2021 papers on glutathione interactions with β-glucan, with the first studying human cells from healthy donors: “(1→3)-β-D-Glucan stimulation induces epigenetic and transcriptomic changes in monocytes associated with increased glutathione (GSH) synthesis and metabolism. Intracellular glutathione levels were crucial in regulating several monocyte antifungal functions including resilience to oxidative stress, immunometabolism, nitric oxide production, phagocytosis, … Continue reading Glutathione primes β-glucan-trained immunity

Sulforaphane’s effects on autism and liver disease

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Here are two more papers that cited Precondition your defenses with broccoli sprouts, starting with a 2024 human / rodent study investigating gut microbiota / sulforaphane’s effects on autism: “Sulforaphane (SFN) has been found to alleviate complications linked with several diseases by regulating gut microbiota (GM), while the effect of GM on SFN for autism … Continue reading Sulforaphane’s effects on autism and liver disease

Taurine’s effects on healthspan and lifespan, Part 2

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Four 2023 papers that cited Part 1, starting with a review of hypothetical parameters for taurine clinical trials that aren’t going to happen because: Drug companies can’t make money from a research area that’s cheap, not patentable, and readily accessible. Government sponsors are likewise not incentivized to act in the public’s interest per their recent … Continue reading Taurine’s effects on healthspan and lifespan, Part 2

Another reason to chew broccoli sprouts

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This 2023 review explored a naturally produced antimicrobial: “This review focuses on the role of abundant hypothiocyanous acid (HOSCN), a potent oxidant that kills bacteria but is non-toxic to human cells. Produced from thiocyanate (SCN−) and hydrogen peroxide (H2O2) in a variety of body sites by peroxidase enzymes, HOSCN has been explored as an agent … Continue reading Another reason to chew broccoli sprouts

A good activity for bad weather days

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A free educational series recorded in 2021-2022 available at https://drgoodenowe.com/dr-goodenowes-educational-seminars/ takes the viewer through underlying research and principles of Dr. Goodenowe’s approach to health. It’s advertised as lasting four hours, but took me two days to view. The series’ discussions and references are background material to better understand later presentations and interviews. Points of interest … Continue reading A good activity for bad weather days

Take Vitamin K2 to protect against aluminum toxicity

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This 2023 rodent study investigated relationships of MK-7 menaquinone, aluminum trichloride, and brain health: “A variety of endogenous and exogenous agents, such as metals and environmental toxins (aluminum, mercury, etc.), can contribute to neurodegeneration, which is of multifactorial clinical occurrence. The current study showed that Alzheimer’s Disease (AD)-like condition was induced in mice by AlCl3 … Continue reading Take Vitamin K2 to protect against aluminum toxicity

A flawed broccoli sprouts clinical trial

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This 2023 human study investigated commercially available broccoli sprouts’ effects on platelets. I’ll provide details of some procedures, but not of findings, as there were several issues: “Administration of intervention (sulforaphane/placebo) was followed in 90 min by administration of standardized caloric challenge PhenFlex. Urine samples were classified into three groups: (A) baseline, green line, (B) after … Continue reading A flawed broccoli sprouts clinical trial

Taurine’s effects on healthspan and lifespan

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A 2023 human / primate / rodent / worm study with 56 coauthors exhaustively investigated taurine effects: “We measured the blood concentration of taurine during aging and investigated the effect of taurine supplementation on healthspan and lifespan in several species. In C57Bl/6J wild-type (WT) mice, serum taurine concentrations declined from 132.3 ± 14.2 ng/ml at … Continue reading Taurine’s effects on healthspan and lifespan

Nrf2 Week #5: Elements

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Two 2023 papers, starting with a cell study of Nrf2 regulating sulfur: “We demonstrated that NRF2 increased intracellular persulfides by upregulating cystine transporter xCT encoded by Slc7a11, a well-known NRF2 target gene. Persulfides have been shown to play an important role in mitochondrial function. Supplementation with glutathione trisulfide (GSSSG), which is a form of persulfide, … Continue reading Nrf2 Week #5: Elements

Eat mushrooms every day?

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Three 2022 papers on amino acid ergothioneine, starting with a human study: “We examined temporal relationships between plasma ergothioneine (ET) status and cognition in a cohort of 470 elderly subjects attending memory clinics in Singapore. All participants underwent baseline plasma ET measurements as well as neuroimaging for cerebrovascular disease (CeVD) and brain atrophy. Neuropsychological tests … Continue reading Eat mushrooms every day?

Broccoli leaves and stems vs. highly-processed food

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This 2022 rodent study investigated whether obesity caused by typical diets could be affected by adding a flour made of broccoli by-products: “Obesity usually arises as a consequence of an excess of energy intake relative to the expense of energy via metabolic and physical activity. However, combinations of genetic, behavioral, and environmental factors can also … Continue reading Broccoli leaves and stems vs. highly-processed food

Sulforaphane nose drops

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This 2022 rodent study compared capabilities of intranasal nanoparticle sulforaphane and free sulforaphane to mitigate brain damage caused by a common cancer treatment: “Non-invasive intranasal (IN) trafficking of therapeutic agents with nanocarriers can enhance efficacy of drug delivery, biodistribution, bioavailability, and absorption against enzymatic degradation and extracellular transportation. Direct IN trafficking of nanocarriers is expected … Continue reading Sulforaphane nose drops

Eat broccoli sprouts for metabolic syndrome

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This 2022 rodent study investigated sulforaphane’s effects on insulin resistance: “Insulin resistance is one of the defining clinical traits of metabolic syndrome, which represents a constellation of metabolic disorders, mainly comprising obesity, type 2 diabetes mellitus, atherogenic dyslipidemia, and hypertension. This study aimed to investigate therapeutic effects and potential mechanisms of sulforaphane (SFN) on high-fat … Continue reading Eat broccoli sprouts for metabolic syndrome

Taurine week #3: Organs

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Three 2022 papers investigated taurine’s effects on organs, starting with a rodent study of sepsis: “Sepsis usually causes multiple organ dysfunctions and high mortality. Pathogenesis of sepsis is thought to be driven by hyperactive inflammation following pathogen invasion. If the immune system fails to eradicate pathogens, immune homeostasis is disturbed, leading to an overwhelming inflammation … Continue reading Taurine week #3: Organs

Betaine and diabetes

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Two 2022 papers on betaine’s effects, starting with a review: “Rodent studies provide evidence that betaine effectively limits many diabetes-related disturbances. Betaine therapy improves glucose tolerance and insulin action, which is strongly associated with changes in insulin-sensitive tissues, such as skeletal muscle, adipose tissue, and liver. Betaine supplementation positively affects multiple genes, which expression is … Continue reading Betaine and diabetes