Two 2020 reviews covered some aspects of a broccoli sprouts primary action – NRF2 signaling pathway activation: “Full understanding of the properties of drug candidates rely partly on the identification, validation, and use of biomarkers to optimize clinical applications. This review focuses on results from clinical trials with four agents known to target NRF2 signaling … Continue reading Eat broccoli sprouts to pivot your internal environment’s signals
This 2020 review subject was melatonin: “The emergence of naturally occurring melatonin and its isomers in fermented foods has opened an exciting new research area. Melatonin is a hormone, an indolamine that predominantly appears in plants, microorganisms, and mammals. The precursor of this molecule is solely the amino acid L‐tryptophan. Melatonin ensures a circadian and … Continue reading Natural sources of melatonin
This 2020 Swiss review subject was potential glutathione therapies for stress: “We examine the available data supporting a role for GSH levels and antioxidant function in the brain in relation to anxiety and stress-related psychopathologies. Several promising compounds could raise GSH levels in the brain by either increasing the availability of its precursors or the … Continue reading Treating psychopathological symptoms will somehow resolve causes?
Ever heard about AGEs? Here are three papers that describe how AGEs affect humans. First is a 2020 Italian review Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System: “Neurodegenerative disease is an umbrella term for different conditions which primarily affect the neurons in the human brain. Currently, … Continue reading Get serious about advanced glycation end products (AGEs)
I was asked for examples of broccoli sprout synergies with supplements mentioned in Week 19 of Changing to a youthful phenotype with broccoli sprouts. I take supplements and broccoli sprouts together an hour or two before meals to keep meal contents from lowering sulforaphane bioavailability. Sulforaphane peaks in plasma between 1 and 2 hours after … Continue reading Broccoli sprout synergies
This 2017 review explored broccoli sprout compounds effects on head hair: “Skin appendages, notably hair follicles (HFs), can be exposed to high levels of reactive oxygen species (ROS), which are generated through metabolic reactions occurring mostly in the mitochondria, peroxisomes and the endoplasmic reticulum as well as in the plasma membrane. Despite their involvement in … Continue reading Eat broccoli sprouts for your hair!
This 2020 Swiss review subject was the interaction of Nrf2 activators and skin: “The electrophile and Nrf2 activator dimethyl fumarate (DMF) is an established and efficient drug for patients suffering from the common inflammatory skin disease psoriasis. DMF is being tested for pharmacological activity in several other inflammatory skin conditions. Psoriasis is a chronic inflammatory … Continue reading Eat broccoli sprouts for your skin!
Here are my Day 70 measurements* to follow up Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts, which had these findings: Keep in mind that I’m not in the population represented by the clinical trial sample: My chronological age is above their inclusion range; My BMI is below their inclusion … Continue reading Day 70 results from Changing to a youthful phenotype with broccoli sprouts
Further investigating A claim of improved cognitive function, Part 3 of Rejuvenation therapy and sulforaphane offered: “Improving brain function does not depend on neurogenesis as much as it does on synapse formation and factors such as NMDA receptors which decline in density with age.” A PubMed “sulforaphane NMDA receptors” search turned up a 2019 cell … Continue reading Upgrade your brain’s switchboard with broccoli sprouts
Reversal of aging and immunosenescent trends with sulforaphane covered only the first 13 minutes of a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends. Commonalities with sulforaphane research were found by PubMed searches of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Continuing … Continue reading Part 2 of Reversal of aging and immunosenescent trends with sulforaphane
Sulforaphane research findings have commonalities with a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends. I did a PubMed search of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Presentation topics through the first 13 minutes were: Thymus – no recent sulforaphane studies … Continue reading Reversal of aging and immunosenescent trends with sulforaphane
The founder of the epigenetic clock methodology with the coauthor of Aging as an unintended consequence released a 2020 rodent study “Reversing age: dual species measurement of epigenetic age with a single clock” at https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.pdf: “We employed six clocks to investigate the rejuvenation effects of a plasma fraction treatment in different rat tissues. Two of … Continue reading A rejuvenation therapy and sulforaphane
This 2020 Australian/UK review subject was AGEs: “AGEs are formed during cooking and food processing or produced endogenously as a consequence of metabolism. The deleterious effects of AGEs are underpinned by their ability to trigger mechanisms well known to elicit metabolic dysfunction, including the activation of inflammatory pathways, oxidative stress and impaired mitochondrial oxidative metabolism. … Continue reading Broccoli sprouts oppose effects of advanced glycation end products (AGEs)
This 2020 Spanish review analyzed recent clinical trials that used broccoli sprouts and their compounds. Stringent criteria for study selection resulted in few trials being considered: “We reduced the timeframe to the last years, from 2012 to the present. We focused our work on the data of studies carried out with human adults with different … Continue reading Reviewing clinical trials of broccoli sprouts and their compounds
This follow up to Growing a broccoli sprouts Victory Garden is what’s gone on during Week 1 of starting to grow broccoli sprouts for a “30 60 grams of fresh broccoli sprouts incorporated daily into the diet”  program. See Week 2 of Changing an inflammatory phenotype with broccoli sprouts for changes. Day 0 – … Continue reading Changing an inflammatory phenotype with broccoli sprouts