This 2019 Australian review subject was fetal adversities: “Adversity during the perinatal period is a significant risk factor for the development of neurodevelopmental disorders long after the causative event. Despite stemming from a variety of causes, perinatal compromise appears to have similar effects on the developing brain, thereby resulting in behavioural disorders of a similar … Continue reading A review of fetal adverse events
This 2019 Singapore human study used Diffusion Tensor Imaging on 5-to-17-day old infants to find: “Our findings showed evidence for region-specific effects of genotype and GxE on individual differences in human fetal development of the hippocampus and amygdala. Gene x Environment models outcompeted models containing genotype or environment only, to best explain the majority of … Continue reading Do genes or maternal environments shape fetal brains?
This 2018 Loma Linda review subject was gestational hypoxia: “Of all the stresses to which the fetus and newborn infant are subjected, perhaps the most important and clinically relevant is that of hypoxia. This review explores the impact of gestational hypoxia on maternal health and fetal development, and epigenetic mechanisms of developmental plasticity with emphasis … Continue reading The lack of oxygen’s epigenetic effects on a fetus
This 2018 US baboon study was on fetal effects from maternal obesity before and during pregnancy: “Approximately 64% of women of childbearing age in the USA [are] overweight or obese. The baboon is a well-characterized animal model sharing many physiological, metabolic, and genetic characteristics with humans allowing direct translation of findings to human pregnancy. Our … Continue reading Maternal obesity causes fetal liver damage
This 2017 Australian review’s subject was epigenetic impacts involving microRNA in adverse intrauterine environments, and how these affected fetal heart tissue development: “We describe how an adverse intrauterine environment can influence the expression of miRNAs (a sub-set of non-coding RNAs) and how these changes may impact heart development. Potential consequences of altered miRNA expression in … Continue reading Epigenetic effects of microRNA on fetal heart development
The fourth paper of Transgenerational epigenetic inheritance week was a 2016 German rodent study of of improperly-termed “transgenerational” epigenetic effects of alcohol: “We investigated 2 generations of offspring born to alcohol-treated mothers. Here, we show that memory impairment and reduced synthesis of acetylcholine occurs in both F1 (exposed to ethanol in utero) and F2 generation (never been … Continue reading “Transgenerationally” inherited epigenetic effects of fetal alcohol exposure
This 2015 Swedish rodent study found: “Women with polycystic ovary syndrome (PCOS) display high circulating androgen levels that may affect the fetus and increase the risk of mood disorders in offspring. Although clinical data are inconsistent, there are indications that androgens play a crucial role in behavior and mood regulation in females. Studies on the … Continue reading Fetal exposure to sex hormones and female anxiety
This 2015 Colorado rodent study found: “Maternal ADN [adiponectin, a hormone produced by fat cells, that regulates fat and glucose metabolism] supplementation reversed the adverse effects of maternal obesity on placental function and fetal growth. Babies of mothers with obesity and/or gestational diabetes mellitus (GDM) are often large at birth and have increased adiposity, which … Continue reading Countering the epigenetic effects of obese mothers on their fetuses
This extremely dense and informative 2014 UK summary study provided details about genomic imprinting: “An unusual epigenetic process in that it is heritable and results in autosomal gene expression according to parent of origin.” Several notes of interest: Figure 3 had a fascinating sketch of how the fetus caused the mother’s hypothalamus to: “Determine forward … Continue reading Epigenetic DNA methylation and demethylation with the developing fetus
This 2014 rodent study was of polycystic ovarian syndrome, which is the leading cause of human female infertility. The researchers could reliably induce this disease in mice while they were still fetuses, but effects didn’t manifest until adulthood! The inducement method exposed the developing female fetuses to androgens such that their testosterone concentration was significantly … Continue reading Sex hormone exposure to the developing female fetus causes infertility in adulthood
Continuing Part 1 with a 2024 rodent healthspan and lifespan study: “We investigated the effects of daily oral supplementation of ergothioneine (ERGO) dissolved in drinking water on lifespan, frailty, and cognitive impairment in male mice from 7 weeks of age to the end of their lives. Ingestion of 4 ~ 5 mg/kg/day of ERGO remarkably extended the … Continue reading Ergothioneine dosing, Part 2
Here are two more papers that cited Precondition your defenses with broccoli sprouts, starting with a 2024 human / rodent study investigating gut microbiota / sulforaphane’s effects on autism: “Sulforaphane (SFN) has been found to alleviate complications linked with several diseases by regulating gut microbiota (GM), while the effect of GM on SFN for autism … Continue reading Sulforaphane’s effects on autism and liver disease
Eight 2023 acetyl-L-carnitine / L-carnitine papers, starting with three healthy human studies: “Thirty healthy volunteers aged between 19 and 52 years were divided randomly into two equal groups, one of which received 1000 mg of L-carnitine (LC) per day over a 12-week period. Total cholesterol and HDL-C increased significantly after supplementation. LC could be useful … Continue reading Take acetyl-L-carnitine if you are healthy
Here’s a 2023 paper on the subject, but let’s first see what it is, from Michigan State University: https://hal.bim.msu.edu/CMEonLine/Autonomic/Sympathetic/Treatment/SuboccipitalRelease/start.html and University of Wisconsin: https://www.fammed.wisc.edu/suboccipital-release-technique/ An instruction paper for osteopaths: “This technique treats migraines, headaches, and neck pain. It can also be used as an adjunct for treating conditions with autonomic dysfunction. Before performing a suboccipital … Continue reading Suboccipital release
The person who knows the most about this subject is Dayan Goodenowe, PhD. Some recent publications include: https://www.frontiersin.org/articles/10.3389/fcell.2022.864842/full “Targeted Plasmalogen Supplementation: Effects on Blood Plasmalogens, Oxidative Stress Biomarkers, Cognition, and Mobility in Cognitively Impaired Persons” https://www.frontiersin.org/articles/10.3389/fcell.2022.866156/full “Brain ethanolamine phospholipids, neuropathology and cognition: A comparative post-mortem analysis of structurally specific plasmalogen and phosphatidyl species” A sample … Continue reading Plasmalogens, Part 1
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