Sex hormone exposure to the developing female fetus causes infertility in adulthood

This 2014 rodent study was of polycystic ovarian syndrome, which is the leading cause of human female infertility.

The researchers could reliably induce this disease in mice while they were still fetuses, but effects didn’t manifest until adulthood! The inducement method exposed the developing female fetuses to androgens such that their testosterone concentration was significantly increased.

Comparing this study with How mothers-to-be program lifelong low testosterone into their unborn male children, we can see that in early development:

  • too much testosterone for a female fetus and
  • too little testosterone for a male fetus

both have lifelong ill effects. “Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome”

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