Sulforaphane vs. too much oxygen

This 2021 rodent study investigated perinatal effects of hyperoxia and sulforaphane: “We demonstrated that early-life oxidant-induced acute lung injury had significant consequences later in life on NRF2-dependent respiratory syncytial virus (RSV) susceptibility in mice. We also determined that increased antioxidant conditions in utero potentially contribute to a decreased risk of postnatal airway disease as we … Continue reading Sulforaphane vs. too much oxygen

Offspring brain effects from maternal adversity

This 2021 rodent study investigated conception through weaning effects on offspring from stressing their mothers: “We investigated consequences of two prenatal insults, prenatal alcohol exposure (PAE) and food-related stress, on DNA methylation profiles of the rat brain during early development. We analyzed patterns in prefrontal cortex, a key brain region involved in cognition, executive function, … Continue reading Offspring brain effects from maternal adversity

Week 87 of Changing to a youthful phenotype with sprouts

This week I dialed back eating microwaved 3-day-old broccoli / red cabbage / mustard sprouts from twice a day to once a day. For my reasoning, here are two papers on broccoli sprouts and thyroid function, with the first a 2018 human study: “We analyzed biochemical measures of thyroid function and thyroid autoimmunity in a … Continue reading Week 87 of Changing to a youthful phenotype with sprouts

Is liver damage reversible?

This 2021 rodent study measured sequential liver changes caused by a high-fat diet: “Using a longitudinal mouse study of diet-induced obesity in male mice, we investigated kinetics of hepatic DNA methylation and gene expression compared to those of obesity-induction to assess if they could be causal for development of insulin resistance. We aimed to find … Continue reading Is liver damage reversible?

All about the betaine, Part 2

Continuing Part 1 by curating a partial outline of a 2021 review: “This review focuses on the biological and beneficial effects of dietary betaine (trimethylglycine), a naturally occurring and crucial methyl donor. Betaine has a neuroprotective role, preserves myocardial function, and prevents pancreatic steatosis. Betaine also attenuates oxidant stress, endoplasmic reticulum stress, inflammation, and cancer … Continue reading All about the betaine, Part 2

All about vasopressin

This 2021 review subject was vasopressin: “Vasopressin is a ubiquitous molecule playing an important role in a wide range of physiological processes, thereby implicated in pathomechanisms of many disorders. The most striking is its central effect in stress-axis regulation, as well as regulating many aspects of our behavior. Arginine-vasopressin (AVP) is a nonapeptide that is … Continue reading All about vasopressin

Microwave your Brassica vegetables

This 2021 review evaluated effects on glucoraphanin and sulforaphane content of cooking broccoli and other Brassica vegetables: “The amount of glucosinolates (GLS) in brassica vegetables can be affected significantly during processing and cooking, depending on their specific conditions and types: Microwaving can retain or even increase content of glucoraphanin (GLR), and can increase production of … Continue reading Microwave your Brassica vegetables

Gut and brain health

This 2021 human review subject was interactions of gut health and disease with brain health and disease: “Actions of microbial metabolites are key for appropriate gut-brain communication in humans. Among these metabolites, short-chain fatty acids (SCFAs), tryptophan, and bile acid metabolites / pathways show strong preclinical evidence for involvement in various aspects of brain function … Continue reading Gut and brain health

Take acetyl-L-carnitine for early-life trauma

This 2021 rodent study traumatized female mice during their last 20% of pregnancy, with effects that included: Prenatally stressed pups raised by stressed mothers had normal cognitive function, but depressive-like behavior and social impairment; Prenatally stressed pups raised by control mothers did not reverse behavioral deficits; and Control pups raised by stressed mothers displayed prenatally … Continue reading Take acetyl-L-carnitine for early-life trauma

Cow milk causes disease

This 2021 review followed up Epigenetic effects of cow’s milk and many papers since then: “Epidemiological studies associate intake of cow milk with an increased risk of diseases, which are associated with overactivated mechanistic target of rapamycin complex 1 (mTORC1) signaling. Milk’s physiological function to maintain high mTORC1 signaling at the beginning of mammalian life … Continue reading Cow milk causes disease

Does sulforaphane treat autism?

A 2021 human study investigated sulforaphane treatments of autistic 3-to-12-year-olds: “Sulforaphane (SF) led to non-statistically significant changes in the total and all subscale scores of the primary outcome measure. Several effects of SF on biomarkers correlated to clinical improvements. SF was very well tolerated and safe and effective based on our secondary clinical measures. Clinical … Continue reading Does sulforaphane treat autism?

Choosing your future with β-glucan

This 2020 rodent study investigated yeast cell wall β-glucan effects on bacterial infections: “β-glucan is a potent inducer of epigenetic and functional reprogramming of innate immune cells, a process called trained immunity, resulting in an enhanced host response against secondary infections. We investigate whether β-glucan exposure confers protection against pulmonary Mycobacterium tuberculosis (Mtb) infection. β-glucan … Continue reading Choosing your future with β-glucan

Our first 1000 days

This 2021 review subject was a measurable aspect of our early lives: “The first 1000 days from conception are a sensitive period for human development programming. During this period, environmental exposures may result in long-lasting epigenetic imprints that contribute to future developmental trajectories. The present review reports on effects of adverse and protective environmental conditions … Continue reading Our first 1000 days