Immune memory vs. immune adaptation

This 2019 Dutch/German/Romanian perspective aimed for a better understanding of immune systems: “Based on molecular, immunological, and evolutionary arguments, we propose that innate immune memory is a primitive form of immune memory present in all living organisms, while adaptive immune memory is an advanced form of immune memory representing an evolutionary innovation in vertebrates. Innate … Continue reading Immune memory vs. immune adaptation

Adaptations to stress encourage mutations in a DNA area that causes diseases

This 2015 Baylor human cell study subject was the underlying mechanisms of cellular responses to environmental stressors of cold, heat, hypoxia, and oxidation: “Because trinucleotide repeats are overrepresented in gene-regulatory proteins, stress-induced trinucleotide repeat mutagenesis may provide a path for the environment to subtly alter gene regulatory networks – with attendant changes in cell behavior – during … Continue reading Adaptations to stress encourage mutations in a DNA area that causes diseases

Sulforaphane in the Goldilocks zone

This 2020 paper reviewed hormetic effects of a broccoli sprout compound: “Sulforaphane (SFN) induces a broad spectrum of chemoprotective effects across multiple organs that are of importance to public health and clinical medicine. This chemoprotection is dominated by hormetic dose responses that are mediated by the Nrf2/ARE pathway and its complex regulatory interactions with other … Continue reading Sulforaphane in the Goldilocks zone

Anti-tumor effects of β-glucan

This comprehensive 2020 rodent study investigated dozens of scenarios for β-glucan in the context of anti-tumor immunity: “Neutrophils and granulopoietic progenitors are major cellular effectors of β-glucan-induced trained immunity. The anti-tumor effect of β-glucan-induced trained immunity was mediated by qualitative changes in neutrophils. A tumor-suppressive phenotype in neutrophils was associated with training of granulopoiesis mediated … Continue reading Anti-tumor effects of β-glucan

Rub some broccoli sprouts on it

This 2020 human/rodent study investigated treating and preventing skin photodamage with sulforaphane: “Alterations in NRF2 signaling have been implicated in aging and stress-induced skin pigmentation disorders in the skin and hair follicles. NRF2 signaling regulates transcriptional programs involved in adaption and survival of cells in the setting of oxidative stress, and oxidative stress occurs in … Continue reading Rub some broccoli sprouts on it

Part 3 of Do broccoli sprouts treat migraines?

This 2019 Swedish review subject was the role of inflammation in migraines: “In this article, we argue that inflammation could have an important role in migraine chronification through a mechanism termed neurogenic neuroinflammation, a phenomenon whereby activation of trigeminal sensory pathways leads to an orchestrated inflammatory response involving immune cells, vascular cells and neurons. No … Continue reading Part 3 of Do broccoli sprouts treat migraines?

Take responsibility for your one precious life – Trained innate immunity

This 2020 review subject was the normal progression of our immune systems: “Age-related alterations in the immune system result in high susceptibility to infections, increased risk of hospitalization and mortality. Defects in adaptive immunity underlie the markedly low vaccine efficiency in the elderly. Despite reduced cellular functions, a systemic increase in inflammatory markers, so-called inflammaging, … Continue reading Take responsibility for your one precious life – Trained innate immunity

Eat broccoli sprouts for your hair!

This 2017 review explored broccoli sprout compounds effects on head hair: “Skin appendages, notably hair follicles (HFs), can be exposed to high levels of reactive oxygen species (ROS), which are generated through metabolic reactions occurring mostly in the mitochondria, peroxisomes and the endoplasmic reticulum as well as in the plasma membrane. Despite their involvement in … Continue reading Eat broccoli sprouts for your hair!

Grow a broccoli sprouts Victory Garden today!

By request, here’s what I recommend after growing and eating broccoli sprouts every day for the past twenty weeks. 1. Develop a strategic goal. Eating broccoli sprouts can achieve several goals. Mine has been to address inflammation. 2. Use a relevant model. I used the 2018 clinical trial Effects of long-term consumption of broccoli sprouts … Continue reading Grow a broccoli sprouts Victory Garden today!

Sulforaphane clinical trials and COVID-19

A plethora of articles have been published this year on how researchers’ favorite topics can / may / should / could / will fix COVID-19. This one was different in that relevant clinical trials were both completed and already underway before a Madness of Crowds behavioral contagion infected us: “It is crucial to understand the … Continue reading Sulforaphane clinical trials and COVID-19

A cherry-picked DNA methylation study

This 2020 US/Sweden/Denmark human study measured twins during their old age: “We evaluate individual differences in DNA methylation at individual CpG sites across the methylome across 10 years in two Scandinavian samples of same‐sex aging twins. We test two competing hypotheses about the longitudinal stability and change in DNA methylation: The contribution of genetic influences … Continue reading A cherry-picked DNA methylation study

Take responsibility for your one precious life – Vitamin D3

Where to start among 6,489 studies and reviews published during the past five years, results from a PubMed search of “dihydroxyvitamin D3.” How about: “Vitamin D plays a fundamental role in body calcium and phosphorous homeostasis, ensuring proper functioning of the skeletomuscular system. Pleiotropic activities include: Anti-inflammatory and immunomodulatory properties (predominantly downregulation of adaptive and … Continue reading Take responsibility for your one precious life – Vitamin D3

Week 6 of Changing an inflammatory phenotype with broccoli sprouts

To follow up Week 5 of Changing an inflammatory phenotype with broccoli sprouts: 1. I had an informative exchange with an author of Microwave broccoli to increase sulforaphane levels. The study provided an optimal sulforaphane end result of “(2.45 µmol/g DW)”. I asked a study author for additional data, and they replied: “The control GLR … Continue reading Week 6 of Changing an inflammatory phenotype with broccoli sprouts

Week 4 of Changing an inflammatory phenotype with broccoli sprouts

To follow up Week 3 of Changing an inflammatory phenotype with broccoli sprouts: 1. I started panning 3-day-old broccoli sprouts before microwaving them in 100 ml of water with a 1000 W microwave on full power for 35 seconds. See Week 6 of Changing an inflammatory phenotype with broccoli sprouts for why I stopped panning. … Continue reading Week 4 of Changing an inflammatory phenotype with broccoli sprouts

An evolutionary view of transgenerational epigenetic inheritance

This 2020 Swiss/German review mainly cited weed, worm, and yeast studies: “RNA interference-related mechanisms can mediate the deposition and transgenerational inheritance of specific chromatin modifications in a truly epigenetic fashion. Epigenetics was initially defined as any heritable change in gene expression patterns without changes in the DNA sequence. Now, epigenetic phenomena are often characterized as … Continue reading An evolutionary view of transgenerational epigenetic inheritance