This 2015 Baylor human cell study subject was the underlying mechanisms of cellular responses to environmental stressors of cold, heat, hypoxia, and oxidation: “Because trinucleotide repeats are overrepresented in gene-regulatory proteins, stress-induced trinucleotide repeat mutagenesis may provide a path for the environment to subtly alter gene regulatory networks—with attendant changes in cell behavior—during development, disease, and evolution.” … Continue reading Adaptations to stress encourage mutations in a DNA area that causes diseases
This 2018 Austrian human study subject was various associations of prenatal testosterone levels to fetal development: “The available evidence suggests, albeit not conclusively, that prenatal testosterone levels may be one cause for the association of sexual orientation with handedness. Associations among women were consistent with predictions of the Geschwind–Galaburda theory (GGT), whereas those among men … Continue reading Epigenetic causes of sexual orientation and handedness?
This 2016 US/Italy article was written from the perspective of regenerative bioengineering: “Higher levels beyond the molecular can have their own unique dynamics that offer better (e.g. more parsimonious and potent) explanatory power than models made at lower levels. Biological systems may be best amenable to models that include information structures (organ shape, size, topological … Continue reading A top-down view of biological goal-directed mechanisms
The coauthor of: A self-referencing study of transgenerational epigenetic inheritance; and A review of epigenetic transgenerational inheritance of reproductive disease pointed out the opportunity for the researchers of A seasonal epigenetic effect of conception on BMI to have their work make a difference in their field: “The ability of environmental epigenetics to promote an adaptive … Continue reading The imperative of human transgenerational studies
This 2018 German human study’s last sentence was: “Additionally we found an association between DNAm [DNA methylation] age acceleration and rLTL [relative leukocyte telomere length], suggesting that this epigenetic clock, at least partially and possibly better than other epigenetic clocks, reflects biological age.” Statements in the study that contradicted, qualified, and limited the concluding sentence … Continue reading Hijacking the epigenetic clock paradigm
This 2018 Netherlands review topic was the long-term epigenetic programming of the innate immune system: “Immunological memory has been classically described for the adaptive immune system, in which naive B and T lymphocytes develop antigen-specific, long-lasting memory cells after encountering a new antigen. Immunological memory is not an exclusive trait of lymphocytes. The function of … Continue reading A dietary supplement that trains the innate immune system
This 2018 Swiss human/rodent study found: “The presence of brown adipose tissue (BAT) and the season of conception are linked to BMI in humans. In mice, we demonstrate that cold exposure (CE) of males, but not females, before mating results in improved systemic metabolism and protection from diet-induced obesity of the male offspring. Adipose tissue … Continue reading A seasonal epigenetic effect of conception on BMI
This 2018 Loma Linda review subject was gestational hypoxia: “Of all the stresses to which the fetus and newborn infant are subjected, perhaps the most important and clinically relevant is that of hypoxia. This review explores the impact of gestational hypoxia on maternal health and fetal development, and epigenetic mechanisms of developmental plasticity with emphasis … Continue reading The lack of oxygen’s epigenetic effects on a fetus
This 2018 Michigan review subject was cancer evolution: “Based on the fact that cancer typically represents a complex adaptive system, where there is no linear relationship between lower-level agents (such as each individual gene mutation) and emergent properties (such as cancer phenotypes), we call for a new strategy based on the evolutionary mechanism of aneuploidy … Continue reading An evolutionary view of stress and cancer
This 2018 UK review subject was colored-hearing experiences from music: “Music-colour synaesthesia has a broad scope encompassing not only tone-colour synaesthesia elicited on hearing individual tones, but a complex and idiosyncratic mixture of phenomenological experiences often mediated by timbre, tempo, emotion and differing musical style. The possession of synaesthesia or absolute pitch was shown to … Continue reading Ideaesthesia!