This 2018 study investigated pain-relieving effects of two broccoli sprout compounds, sulforaphane and chlorogenic acid:

“Pharmacological evidence of the antinociceptive properties of broccoli aqueous extracts and bioactive metabolites were investigated in an experimental model of pain.

It was found that sprouts produced better antinociceptive response than seeds and inflorescence of broccoli, where SFN [sulforaphane] and CA [chlorogenic acid] were partial responsible. Opioid receptors were implicated in the antinociceptive effect of SFN, whereas calcium channels were involved in the concentration-dependent spasmolytic activity.

Our results give evidence of a dose-dependent antinociceptive effect of CA that might act in a synergic interaction with SFN and other metabolites to produce antinociceptive activity.”

https://www.sciencedirect.com/science/article/abs/pii/S0753332218333286 “Broccoli sprouts produce abdominal antinociception but not spasmolytic effects like its bioactive metabolite sulforaphane” (not freely available)

8-day-old broccoli sprouts were treated Days 5-8 with methyl jasmonate to increase glucosinolates as Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts did.

I hadn’t previously noticed papers on “Chlorogenic and Sinapic acid derivatives” that are part of my daily intake, but there’s much recent research. Consider these October 2020 chlorogenic acid papers for example:

• Chlorogenic acid inhibits esophageal squamous cell carcinoma growth in vitro and in vivo by downregulating the expression of BMI1 and SOX2:
  

  “Nutrition research has regarded CGA as a nutraceutical for the prevention and treatment of major chronic diseases. CGA has been proven to possess many health-promoting properties, such as antioxidant, anti-inflammatory, and anti-microbial properties.”

• The Metabolic Effects of Cynara Supplementation in Overweight and Obese Class I Subjects with Newly Detected Impaired Fasting Glycemia: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial:
  

  “Impaired fasting glucose (IFG) is a condition that precedes diabetes and increases the risk of developing it. Studies support the hypoglycemic effect of Cynarascolymus (Cs) [artichoke] extracts due to the content of chlorogenic acid. Cs supplementation has a significant effect on metabolic parameters in IFG patients.”

• Chlorogenic Acid Suppresses miR‐155 and Ameliorates Ulcerative Colitis Through the NF‐κB/NLRP3 inflammasome Pathway:
  

  “CGA prevented colitis by downregulating miR‐155 expression and inactivating the NF‐κB/NLRP3 inflammasome pathway in macrophages.”

• Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid:
  

  “These components appear to share the common mechanisms, among which one related to reactive oxygen species is perhaps the most attractive. EGCG and CGA have different target molecules which might explain the site-specific differences of anti-cancer effects found in human studies.”

• Chlorogenic acid prevents acute myocardial infarction in rats by reducing inflammatory damage and oxidative stress:
  

  “CGA improved the survival rate after MI and demonstrated that CGA had a protective effect on MI by reducing the inflammatory response and exerting antioxidant activity.”

I found If it stinks, it’s good for you as a result of it citing this study. See Broccoli sprout compounds include sinapic acid derivatives to follow on that subject.

I rated this study as Required further work. This is my 31^st week of eating a clinically relevant amount of broccoli sprouts every day, and I still take acetaminophen.