This 2018 study investigated pain-relieving effects of two broccoli sprout compounds, sulforaphane and chlorogenic acid: “Pharmacological evidence of the antinociceptive properties of broccoli aqueous extracts and bioactive metabolites were investigated in an experimental model of pain. It was found that sprouts produced better antinociceptive response than seeds and inflorescence of broccoli, where SFN [sulforaphane] and … Continue reading Eat broccoli sprouts for pain?
This 2020 Texas review subject was long non-coding RNAs: “We review the emerging significance of long non-coding RNAs (lncRNA) as downstream targets and upstream regulators of the Nrf2 signaling pathway, a critical mediator of diverse cellular processes linked to increased cell survival. It is believed that more than 3% of human genes are regulated by … Continue reading Sulforaphane and RNAs
This 2020 Korean letter to a journal editor cited 23 recent papers in support of sulforaphane’s positive effects, mainly in anti-cancer treatments: “Gene expression is mediated by chromatin epigenetic changes, including DNA methylation, histone modifications, promoter-enhancer interactions, and non-coding RNA (microRNA and long non-coding RNA)-mediated regulation. Approximately 50% of all tumor suppressor genes are inactivated … Continue reading Eat broccoli sprouts today!
I’m clearing out the below queue of 27 studies and reviews I’ve partially read this year but haven’t taken the time to curate. I have a pesky full-time job that demands my presence elsewhere during the day. :-\ Should I add any of these back in? Let’s be ready for the next decade! Early life … Continue reading Clearing out the 2019 queue of interesting papers
This 2019 Canadian rodent study found: “Folic acid (FA) supplementation mitigates sperm miRNA profiles transgenerationally following in utero paternal exposure to POPs [persistent organic pollutants]. Across the F1 – F4 generations, sperm miRNA profiles were less perturbed with POPs + FA compared to sperm from descendants of dams treated with POPs alone..and only in F1 … Continue reading Epigenetic inheritance and microRNAs
This 2019 US review subject was caloric restriction (CR) without malnutrition: “Cellular adaptation that occurs in response to dietary patterns can be explained by alterations in epigenetic mechanisms such as DNA methylation, histone modifications, and microRNA. Epigenetic reprogramming of the underlying chronic low-grade inflammation by CR can lead to immuno-metabolic adaptations that enhance quality of … Continue reading Caloric restriction’s epigenetic effects
This 2019 Dutch/German/Romanian perspective aimed for a better understanding of immune systems: “Based on molecular, immunological, and evolutionary arguments, we propose that innate immune memory is a primitive form of immune memory present in all living organisms, while adaptive immune memory is an advanced form of immune memory representing an evolutionary innovation in vertebrates. Innate … Continue reading Immune memory vs. immune adaptation
This 2018 Chinese review highlighted areas in which CRISPR/Cas9 technology has, is, and could be applied to rewrite epigenetic changes: “CRISPR/Cas9-mediated epigenome editing holds a great promise for epigenetic studies and therapeutics. It could be used to selectively modify epigenetic marks at a given locus to explore mechanisms of how targeted epigenetic alterations would affect … Continue reading Reversing epigenetic changes with CRISPR/Cas9
This 2018 German review was comprehensive for its subject, epigenetic control of variation and stochasticity in metabolic disease. I’ll focus on one aspect, phenotypic variation: “Phenotypic [Mendelian] variation can result both from gain- and loss-of-function mutations. Because of the extreme interconnectivity of cell regulatory networks, even at the cellular level, predicting the impact of a … Continue reading Epigenetic variations in metabolism
This 2018 Belgian review subject was in part the transgenerational epigenetic effects of maternal obesity during pregnancy. The subject was tailored for the journal in which it appeared, Atherosclerosis, so other transgenerationally inherited epigenetic effects weren’t reviewed: “The transgenerational impact of these alterations in methylation patterns are only shown in animal studies with HFD [high-fat … Continue reading Transgenerational epigenetic effects of maternal obesity during pregnancy
This 2018 Loma Linda review subject was gestational hypoxia: “Of all the stresses to which the fetus and newborn infant are subjected, perhaps the most important and clinically relevant is that of hypoxia. This review explores the impact of gestational hypoxia on maternal health and fetal development, and epigenetic mechanisms of developmental plasticity with emphasis … Continue reading The lack of oxygen’s epigenetic effects on a fetus
This 2018 Washington rodent study subject was transgenerational epigenetic inheritance of disease caused by a fungicide that’s been phased out or banned for over a decade: “This study was designed to help understand how three different epigenetic processes in sperm are correlated with vinclozolin-induced epigenetic transgenerational inheritance of disease. Most DMRs [differential DNA-methylated regions] identified … Continue reading A self-referencing study of transgenerational epigenetic inheritance
This 2018 US Veterans Administration review subject was resiliency and stress responses: “Neurobiological and behavioral responses to stress are highly variable. Exposure to a similar stressor can lead to heterogeneous outcomes — manifesting psychopathology in one individual, but having minimal effect, or even enhancing resilience, in another. We highlight aspects of stress response modulation related … Continue reading Resiliency in stress responses
This US 2018 review lead author was a gynecologic oncologist in private practice: “Sexual orientation is biologically conferred in the first trimester of pregnancy. Gender identity is biologically conferred during the middle trimester of pregnancy. Since the genitals differentiate in the first trimester, and the brain becomes imprinted in the latter half of gestation, it … Continue reading Are there epigenetic causes for sexual orientation and gender identity?
This 2018 Loma Linda review subject was epigenetic interventions for aging: “Epigenomic markers of aging, global DNA hypomethylation and promoter-specific hypermethylation may be engendered by iron and HCys [homocysteine] retention. MiR-29/p53 axis may reverse age-related methylomic shifts, stabilizing both the genome and the epigenome, therefore removing a major risk factor of neurodegeneration. Lowering iron and … Continue reading Faith-tainted epigenetics