Four 2023 papers with different chondroitin sulfate doses, starting with a review: “This article aims to provide an up-to-date view of current literature regarding biological effects and efficacy of chondroitin sulfate (CS), and discusses the quality of available CS supplements and the current direction in CS investigation. A meta-analysis published in 2019 concluded that CS … Continue reading Chondroitin sulfate dosing
Two reviews of Nrf2 relationships with our two immune systems, starting with adaptive immunity: “We highlight recent findings about the influence of Keap1 and Nrf2 in development and effector functions of adaptive immune cells, T lymphocytes and B lymphocytes. We summarize Nrf2 research potential and targetability for treating immune pathologies. Immune cells have mechanisms in … Continue reading Nrf2 Week #7: Immunity
This 2023 primate study investigated the body’s capability to remember prenatal experiences influencing later life: “Maternal stressors and other environmental factors affect the developing embryo and fetus in ways that lead to increased susceptibility for chronic disease in later life. Developmental programming of chronic low-grade inflammation plays an important role in onset and progression of … Continue reading Remembering life before birth
1. I’ve continued daily practices from Year Two with microwaved 3-day-old broccoli, red cabbage, and mustard sprouts for 13 times longer now than any sulforaphane clinical trial. I haven’t had another three-year period in my life where I wasn’t sick even once! The main difference over the past year is that I eat AGE-less chicken … Continue reading Year Three of Changing to a youthful phenotype with sprouts
A 2023 review of 28 human clinical trials investigating broccoli sprout compounds brought up this post’s title by omitting discussion of it: “In order to determine the effective reference dose of a broccoli sprouts beverage for detoxifying carcinogenic air pollutants (benzene), Chen et al. administrated a drink enriched with glucoraphanin (GR) and sulforaphane (SFN) from … Continue reading Does eating broccoli sprouts influence biological age?
Three papers on sulforaphene, starting with a 2022 in vitro digestion study by Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts group: “This work aims to assess anti-inflammatory potential of bioactive compounds of cruciferous sprouts red radish (RRS) and red cabbage (RCS) in their bioaccessible form (obtained by the digestion of … Continue reading Sulforaphene, a natural analog of sulforaphane
A 2022 review of Nrf2 signaling hilariously avoided mentioning sulforaphane, although of ~4,000 sulforaphane published articles, two were cited. I’ll curate it anyway to highlight referenced brain effects. “A good stability of NRF2 activity is crucial to maintain redox balance and therefore brain homeostasis. In this review, we have gathered recent data about the contribution … Continue reading Broccoli sprouts and your brain
This 2021 rodent study investigated perinatal effects of hyperoxia and sulforaphane: “We demonstrated that early-life oxidant-induced acute lung injury had significant consequences later in life on NRF2-dependent respiratory syncytial virus (RSV) susceptibility in mice. We also determined that increased antioxidant conditions in utero potentially contribute to a decreased risk of postnatal airway disease as we … Continue reading Sulforaphane vs. too much oxygen
This 2021 rodent study investigated sulforaphane pretreatment’s role in reducing liver injuries: “As a double blood supply organ of the portal vein and artery, the liver is highly sensitive to ischemia, and is one of the common organs to suffer from hepatic ischemia-reperfusion injury (HI/RI). HI/RI leads to overproduction of reactive oxygen species (ROS). Overdoses … Continue reading Eat broccoli sprouts for your liver
I was recently asked about taking rapamycin for its effects on mTOR. I replied that diet could do the same thing. Here’s a 2021 review outlining such effects: “As common, progressive, and chronic causes of disability and death, neurodegenerative diseases (NDDs) significantly threaten human health, while no effective treatment is available. Recent studies have revealed … Continue reading Natural products vs. neurodegenerative diseases
This 2021 study investigated gut microbiota differences between 100 AD patients and 71 age- and gender-matched controls: “Structural changes in fecal microbiota were evident in Chinese AD patients, with decreased alpha-diversity indices and altered beta-diversity ones, evidence of structurally dysbiotic AD microbiota. Interestingly, traditionally beneficial bacteria, such as Bifidobacterium and Akkermansia, increase in these AD … Continue reading Go with the Alzheimer’s Disease evidence
Two 2021 reviews covered gut microbiota. The first was gut microbial origins of metabolites produced from our diets, and mutual effects: “Gut microbiota has emerged as a virtual endocrine organ, producing multiple compounds that maintain homeostasis and influence function of the human body. Host diets regulate composition of gut microbiota and microbiota-derived metabolites, which causes … Continue reading Treat your gut microbiota as one of your organs
To follow up topics of Part 1‘s interview: 1. “We each have a unique microbial signature in the gut. Metabolites that you produce might not be the same ones that I produce. This makes clinical studies very difficult because you don’t have a level playing field.” This description of inter-individual variability could inform researchers’ investigations … Continue reading Part 2 of Switch on your Nrf2 signaling pathway
An informative interview to start this year with the author of Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease: The Antioxidant Dilemma with Dr. Christine Houghton “The thing about science is, the more you know, the more you realise you don’t know. And I have … Continue reading Switch on your Nrf2 signaling pathway
This 2020 food chemistry review provided phenolic-compound reasons to eat oats: “Phenolamides result from the conjugation of hydroxycinnamic acids with amines. These products contain a variety of metabolic, chemical, and functional capabilities due to the large number of possible combinations among the parent compounds. Of the currently known phenolamides, the most common are avenanthramides (AVAs), … Continue reading Eat oats today!
Surface Your Real Self 