A review of sulforaphane and aging

This 2019 Mexican review stated: “We describe some of the molecular and physical characteristics of SFN, its mechanisms of action, and the effects that SFN treatment induces in order to discuss its relevance as a ‘miraculous’ drug to prevent aging and neurodegeneration. SFN has been shown to modulate several cellular pathways in order to activate … Continue reading A review of sulforaphane and aging

Part 2 of Reversal of aging and immunosenescent trends with sulforaphane

Reversal of aging and immunosenescent trends with sulforaphane covered only the first 13 minutes of a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends.  Commonalities with sulforaphane research were found by PubMed searches of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Continuing … Continue reading Part 2 of Reversal of aging and immunosenescent trends with sulforaphane

Reevaluate findings in another paradigm

It’s challenging for people to change their framework when their paychecks or mental state or reputations depend on it not changing. I’ll use The hypothalamus and aging as an example. The review was alright for partial fact-finding up through 2018. The review’s facts were limited, however, to what fit into the reviewers’ paradigm. The 2015 … Continue reading Reevaluate findings in another paradigm

An environmental signaling paradigm of aging

To follow up A rejuvenation therapy and sulforaphane, the study’s lead laboratory researcher provided evidence for an environmental signaling paradigm of aging in this 2015 paper: “The age-phenotype of a cell or organ depends on its environment and not its history. Organ dysfunction is not the cause of aging, but is the result of its … Continue reading An environmental signaling paradigm of aging

A rejuvenation therapy and sulforaphane

The founder of the epigenetic clock methodology with the coauthor of Aging as an unintended consequence released a 2020 rodent study “Reversing age: dual species measurement of epigenetic age with a single clock” at https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.pdf: “We employed six clocks to investigate the rejuvenation effects of a plasma fraction treatment in different rat tissues. Two of … Continue reading A rejuvenation therapy and sulforaphane

Week 5 of Changing an inflammatory phenotype with broccoli sprouts

To follow up Week 4 of Changing an inflammatory phenotype with broccoli sprouts: 1. I didn’t get around to curating a 2019 Spanish review Sorting out the Value of Cruciferous Sprouts as Sources of Bioactive Compounds for Nutrition and Health. Some highlights: “Sprouts represent a valuable source of diverse micronutrients (vitamins, minerals, and amino acids), … Continue reading Week 5 of Changing an inflammatory phenotype with broccoli sprouts

Broccoli sprouts oppose effects of advanced glycation end products (AGEs)

This 2020 Australian/UK review subject was AGEs: “AGEs are formed during cooking and food processing or produced endogenously as a consequence of metabolism. The deleterious effects of AGEs are underpinned by their ability to trigger mechanisms well known to elicit metabolic dysfunction, including the activation of inflammatory pathways, oxidative stress and impaired mitochondrial oxidative metabolism. … Continue reading Broccoli sprouts oppose effects of advanced glycation end products (AGEs)

Changing an inflammatory phenotype with broccoli sprouts

This follow up to Growing a broccoli sprouts Victory Garden is what’s gone on during Week 1 of starting to grow broccoli sprouts for a “30 60 grams of fresh broccoli sprouts incorporated daily into the diet” [1] program. See Week 2 of Changing an inflammatory phenotype with broccoli sprouts for changes. Day 0 – … Continue reading Changing an inflammatory phenotype with broccoli sprouts

Get outside today

This 2019 Finnish review focused on vitamin D’s immune system effects: “The epigenome of human monocytes is at multiple levels sensitive to vitamin D. These data served as the basis for the chromatin model of vitamin D signaling, which mechanistically explains the activation of a few hundred primary vitamin D target genes. Vitamin D and … Continue reading Get outside today

Effects of advanced glycation end products on quality of life and lifespan

This 2018 Chinese review concerned advanced glycation end products (AGE) mobility interventions: “Only a limited number of studies have focused on measuring the effects of low AGEs levels or AGEs inhibitors on mobility, although many observational human studies and in vitro studies have reported the correlation of AGEs with and the contribution of AGEs to … Continue reading Effects of advanced glycation end products on quality of life and lifespan