Get outside today

This 2019 Finnish review focused on vitamin D’s immune system effects: “The epigenome of human monocytes is at multiple levels sensitive to vitamin D. These data served as the basis for the chromatin model of vitamin D signaling, which mechanistically explains the activation of a few hundred primary vitamin D target genes. Vitamin D and … Continue reading Get outside today

Effects of advanced glycation end products on quality of life and lifespan

This 2018 Chinese review concerned advanced glycation end products (AGE) mobility interventions: “Only a limited number of studies have focused on measuring the effects of low AGEs levels or AGEs inhibitors on mobility, although many observational human studies and in vitro studies have reported the correlation of AGEs with and the contribution of AGEs to … Continue reading Effects of advanced glycation end products on quality of life and lifespan

The persistence of epigenetic marks in Type 1 diabetes

This 2016 California human study found: “A persistency of DNA methylation over time at key genomic loci associated with diabetic complications. Two sets of DNAs collected at least 16–17 years apart from the same participants are used to show the persistency of DNA-me over time. Twelve annotated differentially methylated loci were common in both WB … Continue reading The persistence of epigenetic marks in Type 1 diabetes

Lack of oxygen’s epigenetic effects

This 2016 Finnish review subject was the epigenetic effects of hypoxia: “Ever since the Cambrian period, oxygen availability has been in the center of energy metabolism. Hypoxia stabilizes the expression of hypoxia-inducible transcription factor-1α (HIF-1α), which controls the expression of hundreds of survival genes related to enhanced energy metabolism and autophagy. There are several other … Continue reading Lack of oxygen’s epigenetic effects

A followup study of DNA methylation and age

This 2016 Finnish human study was a followup to A study of DNA methylation and age: “At the 2.55-year follow-up, we identified 19 mortality-associated CpG sites that mapped to genes functionally clustering around the nuclear factor kappa B (NF-κB) complex. None of the mortality-associated CpG sites overlapped with the established aging-associated DNAm sites. Our results … Continue reading A followup study of DNA methylation and age