Go with the Alzheimer’s Disease evidence

This 2021 study investigated gut microbiota differences between 100 AD patients and 71 age- and gender-matched controls: “Structural changes in fecal microbiota were evident in Chinese AD patients, with decreased alpha-diversity indices and altered beta-diversity ones, evidence of structurally dysbiotic AD microbiota. Interestingly, traditionally beneficial bacteria, such as Bifidobacterium and Akkermansia, increase in these AD … Continue reading Go with the Alzheimer’s Disease evidence

Treat your gut microbiota as one of your organs

Two 2021 reviews covered gut microbiota. The first was gut microbial origins of metabolites produced from our diets, and mutual effects: “Gut microbiota has emerged as a virtual endocrine organ, producing multiple compounds that maintain homeostasis and influence function of the human body. Host diets regulate composition of gut microbiota and microbiota-derived metabolites, which causes … Continue reading Treat your gut microbiota as one of your organs

Part 2 of Switch on your Nrf2 signaling pathway

To follow up topics of Part 1‘s interview: 1. “We each have a unique microbial signature in the gut. Metabolites that you produce might not be the same ones that I produce. This makes clinical studies very difficult because you don’t have a level playing field.” This description of inter-individual variability could inform researchers’ investigations … Continue reading Part 2 of Switch on your Nrf2 signaling pathway

Switch on your Nrf2 signaling pathway

An informative interview to start this year with the author of Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease: The Antioxidant Dilemma with Dr. Christine Houghton “The thing about science is, the more you know, the more you realise you don’t know. And I have … Continue reading Switch on your Nrf2 signaling pathway

Eat oats today!

This 2020 food chemistry review provided phenolic-compound reasons to eat oats: “Phenolamides result from the conjugation of hydroxycinnamic acids with amines. These products contain a variety of metabolic, chemical, and functional capabilities due to the large number of possible combinations among the parent compounds. Of the currently known phenolamides, the most common are avenanthramides (AVAs), … Continue reading Eat oats today!

Clearing out the 2020 queue of interesting papers

I’ve partially read these 39 studies and reviews, but haven’t taken time to curate them. Early Life Intergenerational Transmission of Cortical Sulcal Patterns from Mothers to their Children (not freely available) Differences in DNA Methylation Reprogramming Underlie the Sexual Dimorphism of Behavioral Disorder Caused by Prenatal Stress in Rats Maternal Diabetes Induces Immune Dysfunction in … Continue reading Clearing out the 2020 queue of interesting papers

Does reprogramming signaling pathways create memories?

This 2020 study investigated genes and signaling pathways for inflammatory memory: “Fibroblast-like synoviocytes (FLS) play a critical role in pathogenesis of rheumatoid arthritis (RA). Chronic inflammation induces transcriptomic and epigenetic modifications that imparts a persistent catabolic phenotype to the FLS, despite their dissociation from the inflammatory environment. Sustained activated genes established pro-inflammatory signaling components known … Continue reading Does reprogramming signaling pathways create memories?

Sulforaphane in the Goldilocks zone

This 2020 paper reviewed hormetic effects of a broccoli sprout compound: “Sulforaphane (SFN) induces a broad spectrum of chemoprotective effects across multiple organs that are of importance to public health and clinical medicine. This chemoprotection is dominated by hormetic dose responses that are mediated by the Nrf2/ARE pathway and its complex regulatory interactions with other … Continue reading Sulforaphane in the Goldilocks zone

Dietary contexts matter

Two papers illustrated how actions of food compounds are affected by their contexts. The first was a 2020 UCLA rodent study: “Long-chain polyunsaturated fatty acids (PUFAs), particularly omega-3 (n-3) PUFAs, have been indicated to play important roles in various aspects of human health. Controversies are observed in epidemiological and experimental studies regarding the benefits or … Continue reading Dietary contexts matter

Rub some broccoli sprouts on it

This 2020 human/rodent study investigated treating and preventing skin photodamage with sulforaphane: “Alterations in NRF2 signaling have been implicated in aging and stress-induced skin pigmentation disorders in the skin and hair follicles. NRF2 signaling regulates transcriptional programs involved in adaption and survival of cells in the setting of oxidative stress, and oxidative stress occurs in … Continue reading Rub some broccoli sprouts on it

Eat broccoli sprouts to pivot your internal environment’s signals

Two 2020 reviews covered some aspects of a broccoli sprouts primary action – NRF2 signaling pathway activation: “Full understanding of the properties of drug candidates rely partly on the identification, validation, and use of biomarkers to optimize clinical applications. This review focuses on results from clinical trials with four agents known to target NRF2 signaling … Continue reading Eat broccoli sprouts to pivot your internal environment’s signals

Part 3 of Do broccoli sprouts treat migraines?

This 2019 Swedish review subject was the role of inflammation in migraines: “In this article, we argue that inflammation could have an important role in migraine chronification through a mechanism termed neurogenic neuroinflammation, a phenomenon whereby activation of trigeminal sensory pathways leads to an orchestrated inflammatory response involving immune cells, vascular cells and neurons. No … Continue reading Part 3 of Do broccoli sprouts treat migraines?

Eat broccoli sprouts for your skin!

This 2020 Swiss review subject was the interaction of Nrf2 activators and skin: “The electrophile and Nrf2 activator dimethyl fumarate (DMF) is an established and efficient drug for patients suffering from the common inflammatory skin disease psoriasis. DMF is being tested for pharmacological activity in several other inflammatory skin conditions. Psoriasis is a chronic inflammatory … Continue reading Eat broccoli sprouts for your skin!

Sulforaphane clinical trials and COVID-19

A plethora of articles have been published this year on how researchers’ favorite topics can / may / should / could / will fix COVID-19. This one was different in that relevant clinical trials were both completed and already underway before a Madness of Crowds behavioral contagion infected us: “It is crucial to understand the … Continue reading Sulforaphane clinical trials and COVID-19

Take responsibility for your one precious life – Zinc

This 2020 review highlighted earlier clinical data on zinc: “Zinc is known to modulate antiviral and antibacterial immunity and regulate inflammatory response. Zinc possesses anti-inflammatory activity by inhibiting NF-κB signaling and modulation of regulatory T-cell functions. The most critical role of zinc is demonstrated for the immune system. Zinc regulates proliferation, differentiation, maturation, and functioning … Continue reading Take responsibility for your one precious life – Zinc