If it stinks, it’s good for you

This 2019 review subject was hydrogen sulfide and broccoli sprout compounds:

“Release of H2S was identified as a hidden mechanism responsible for effects of natural compounds that were used for a long time for pharmacological, therapeutic or nutraceutical purposes. For instance, the release of H2S was recognized as the main mechanism accounting for the biological effects of garlic.

There is evidence of a close overlap between numerous physiological / biological effects attributed to natural ITCs [isothiocyanates] and H2S. They both behave as antioxidant and anti-inflammatory agents, are activators of potassium channels modulating a vasodilatory effect, and are chemopreventive agents. Moreover, an impressive overlap can be observed in the molecular mechanisms of action.

Vascular inflammation results from the persistence of oxidative and/or inflammatory stimuli on the endothelium and vascular smooth muscle. These types of stimuli can be a consequence of prolonged status of mild inflammation and are typical in certain metabolic / cardiovascular diseases, spreading to all organs and tissues.

Advanced glycation end products (AGEs) are responsible for an increase in LDL. Binding of AGEs to their receptors RAGE results in an increase in intracellular ROS generation and in activation of NF-kB. Oral consumption of SFN [sulforaphane] precursor-rich broccoli sprouts decreases the serum levels of AGEs in humans.

Inflammatory response plays a pivotal role in initiation and maintenance of chronic neuropathic pain. Inhaling low concentrations of H2S protects motor neurons from degeneration and delayed paraplegia in a mouse model of sciatic constriction injury. This effect has been ascribed to the activation of the Nrf2 pathway.

Dose-dependent rise of the pain threshold mediated by SFN was fully prevented by simultaneous administration of hemoglobin, confirming that H2S is likely to be the real player in ITC-induced analgesia. Kv7 channel activation can be considered one of the main mechanisms in the antinociceptive activity of H2S-releasing drugs.”

https://www.liebertpub.com/doi/10.1089/ars.2019.7888 “Organic Isothiocyanates as Hydrogen Sulfide Donors” (not freely available)

These reviewers were long on equivalencies and short on proofs. Unlike study researchers, reviewers aren’t bound to demonstrate evidence from tested hypotheses. Reviewers are free to:

  • Express their beliefs as facts;
  • Over/under emphasize study limitations; and
  • Disregard and misrepresent evidence as they see fit.

Study researchers are obligated to provide detailed analyses of why observed effects couldn’t have been produced from unobserved causes. That didn’t happen here.


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