The next phase of reversing aging and immunosenescent trends

Dr. Greg Fahy earlier this week provided an update on the November 2020 TRIIM-X follow-on to the September 2019 TRIIM curated in Reversal of aging and immunosenescent trends. Emphasis was on reproducibility: 23:45 Dr. Steve Horvath reanalyzed TRIIM for the plasma portion of Levine’s PhenoAge epigenetic clock. Results were congruent with four other epigenetic clocks … Continue reading The next phase of reversing aging and immunosenescent trends

Part 2 of Reversal of aging and immunosenescent trends with sulforaphane

Reversal of aging and immunosenescent trends with sulforaphane covered only the first 13 minutes of a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends.  Commonalities with sulforaphane research were found by PubMed searches of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Continuing … Continue reading Part 2 of Reversal of aging and immunosenescent trends with sulforaphane

Reversal of aging and immunosenescent trends with sulforaphane

Sulforaphane research findings have commonalities with a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends. I did a PubMed search of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Presentation topics through the first 13 minutes were: Thymus – no recent sulforaphane studies … Continue reading Reversal of aging and immunosenescent trends with sulforaphane

Organismal aging and cellular senescence

I’ll curate this 2019 German review through its figures: “With the discovery of beneficial aspects of cellular senescence and evidence of senescence being not limited to replicative cellular states, a redefinition of our comprehension of aging and senescence appears scientifically overdue. Figure 1. Current determinants and relevant open questions, marking the processes of aging and … Continue reading Organismal aging and cellular senescence

Reversal of aging and immunosenescent trends

The title of this post is essentially the same as the 2019 human clinical trial: “Epigenetic aging can be reversed in humans. Using a protocol intended to regenerate the thymus, we observed protective immunological changes, improved risk indices for many age‐related diseases, and a mean epigenetic age approximately 1.5 years less than baseline after 1 … Continue reading Reversal of aging and immunosenescent trends

Cell senescence and DNA methylation

This 2018 Baltimore cell study found: “Based on similarities in overall methylation patterns in replicative senescence and cancers, it is hypothesized that tumor-promoting DNA methylation in cancers derives from cells escaping senescence. We show that the tumor-associated methylation changes evolve independently of senescence and are pro-survival events with functional implications contrasting that in senescence. In … Continue reading Cell senescence and DNA methylation

Using an epigenetic clock to distinguish cellular aging from senescence

The 2016 UK/UCLA human study found: “Induction of replicative senescence (RS) and oncogene-induced senescence (OIS) are accompanied by ageing of the cell. However, senescence induced by DNA damage is not, even though RS and OIS activate the cellular DNA damage response pathway, highlighting the independence of senescence from cellular ageing. We used primary endothelial cells … Continue reading Using an epigenetic clock to distinguish cellular aging from senescence

Broccoli sprouts and your brain

A 2022 review of Nrf2 signaling hilariously avoided mentioning sulforaphane, although of ~4,000 sulforaphane published articles, two were cited. I’ll curate it anyway to highlight referenced brain effects. “A good stability of NRF2 activity is crucial to maintain redox balance and therefore brain homeostasis. In this review, we have gathered recent data about the contribution … Continue reading Broccoli sprouts and your brain

Variable aging measurements

Two papers on aging measurements, starting with a 2022 human study: “We collected longitudinally across the adult age range a comprehensive list of phenotypes within four domains (body composition, energetics, homeostatic mechanisms and neurodegeneration / neuroplasticity) and functional outcomes. We integrated individual deviations from population trajectories into a global longitudinal phenotypic metric of aging. We … Continue reading Variable aging measurements

CD38 and balance

I’ll highlight this 2022 review’s relationships between inflammation and cluster of differentiation 38: “We review the nicotinamide adenine dinucleotide (NAD) catabolizing enzyme CD38, which plays critical roles in pathogenesis of diseases related to infection, inflammation, fibrosis, metabolism, and aging. NAD is a cofactor of paramount importance for an array of cellular processes related to mitochondrial … Continue reading CD38 and balance

Epigenetic clocks so far in 2021

2021’s busiest researcher took time out this month to update progress on epigenetic clocks: Hallmarks of aging aren’t all associated with epigenetic aging. Interventions that increase cellular lifespan aren’t all associated with epigenetic aging. Many of his authored or coauthored 2021 papers developed human / mammalian species relative-age epigenetic clocks. Relative-age epigenetic clocks better predict … Continue reading Epigenetic clocks so far in 2021

Back pain and advanced glycation end products (AGEs)

Two 2020 rodent studies investigated intervertebral disk degeneration, with the first on AGEs’ role: “This study evaluated the role of AGEs and RAGE in driving early intervertebral disk (IVD) degeneration processes in mice. Aging and diabetes are associated with increased low-back pain and IVD degeneration, yet causal mechanisms remain uncertain. AGEs: Accumulate in IVDs from … Continue reading Back pain and advanced glycation end products (AGEs)

Vitamin K-dependent proteins

This 2020 review focused on three Vitamin K-dependent proteins (VKDPs): “We summarize three important emerging VKDPs: Growth arrest‑specific protein 6 (Gas 6), Gla‑rich protein (GRP) and periostin in terms of their functions in physiological and pathological conditions. As examples: Carboxylated Gas 6 and GRP effectively protect blood vessels from calcification; Gas 6 protects from acute … Continue reading Vitamin K-dependent proteins

Cow milk causes disease

This 2021 review followed up Epigenetic effects of cow’s milk and many papers since then: “Epidemiological studies associate intake of cow milk with an increased risk of diseases, which are associated with overactivated mechanistic target of rapamycin complex 1 (mTORC1) signaling. Milk’s physiological function to maintain high mTORC1 signaling at the beginning of mammalian life … Continue reading Cow milk causes disease

Gut microbiota and aging

This 2020 review explored the title subject: “The human body contains 1013 human cells and 1014 commensal microbiota. Gut microbiota play vital roles in human development, physiology, immunity, and nutrition. Human lifespan was thought to be determined by the combined influence of genetic, epigenetic, and environmental factors including lifestyle-associated factors such as exercise or diet. … Continue reading Gut microbiota and aging