A 2023 rodent study investigated Nrf2’s capacity to reverse cell senescence: “Poly-D,L-lactic acid (PDLLA) filler corrects soft tissue volume loss by increasing collagen synthesis in the dermis. Adipose-derived stem cells (ASCs) are known to attenuate the decrease in fibroblast collagen synthesis that occurs during aging. Conclusions: PDLLA increased macrophage NRF2 expression, resulting in increased M2 … Continue reading Nrf2 and senescence, Part 2
A 2023 rodent study investigated Nrf2’s capacity to cause cell senescence: “The KEAP1-NRF2 pathway is a stress response pathway which has been maintained by natural selection due to its ability to benefit survival of the host organism. One important distinction between this pathway and other stress response pathways such as p53, is that chronic activation … Continue reading Nrf2 and senescence, Part 1
Dr. Greg Fahy earlier this week provided an update on the November 2020 TRIIM-X follow-on to the September 2019 TRIIM curated in Reversal of aging and immunosenescent trends. Emphasis was on reproducibility: 23:45 Dr. Steve Horvath reanalyzed TRIIM for the plasma portion of Levine’s PhenoAge epigenetic clock. Results were congruent with four other epigenetic clocks … Continue reading The next phase of reversing aging and immunosenescent trends
Reversal of aging and immunosenescent trends with sulforaphane covered only the first 13 minutes of a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends. Commonalities with sulforaphane research were found by PubMed searches of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Continuing … Continue reading Part 2 of Reversal of aging and immunosenescent trends with sulforaphane
Sulforaphane research findings have commonalities with a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends. I did a PubMed search of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Presentation topics through the first 13 minutes were: Thymus – no recent sulforaphane studies … Continue reading Reversal of aging and immunosenescent trends with sulforaphane
I’ll curate this 2019 German review through its figures: “With the discovery of beneficial aspects of cellular senescence and evidence of senescence being not limited to replicative cellular states, a redefinition of our comprehension of aging and senescence appears scientifically overdue. Figure 1. Current determinants and relevant open questions, marking the processes of aging and … Continue reading Organismal aging and cellular senescence
The title of this post is essentially the same as the 2019 human clinical trial: “Epigenetic aging can be reversed in humans. Using a protocol intended to regenerate the thymus, we observed protective immunological changes, improved risk indices for many age‐related diseases, and a mean epigenetic age approximately 1.5 years less than baseline after 1 … Continue reading Reversal of aging and immunosenescent trends
This 2018 Baltimore cell study found: “Based on similarities in overall methylation patterns in replicative senescence and cancers, it is hypothesized that tumor-promoting DNA methylation in cancers derives from cells escaping senescence. We show that the tumor-associated methylation changes evolve independently of senescence and are pro-survival events with functional implications contrasting that in senescence. In … Continue reading Cell senescence and DNA methylation
The 2016 UK/UCLA human study found: “Induction of replicative senescence (RS) and oncogene-induced senescence (OIS) are accompanied by ageing of the cell. However, senescence induced by DNA damage is not, even though RS and OIS activate the cellular DNA damage response pathway, highlighting the independence of senescence from cellular ageing. We used primary endothelial cells … Continue reading Using an epigenetic clock to distinguish cellular aging from senescence
Continuing Part 1 with three 2024 preprint studies, starting with an investigation of neuroinflammation in high school athletes: “Axons are long fibers conducting nerve impulses from nerve cells to synaptic ends. Like electric wires, axons are insulated by the myelin sheath produced by oligodendrocytes (ODC) in the brain or Schwann cells in the periphery. The … Continue reading Maintaining your myelin, Part 2
Three papers on myelin and oligodendrocytes, starting with a 2023 review: “Myelin is the spiral ensheathment of axons by a lipid and cholesterol-rich glial cell membrane that reduces capacitance and increases resistance of the axonal membrane. Axonal myelination speeds up nerve conduction velocity as a function of axon diameter. While myelination proceeds rapidly after birth … Continue reading Maintaining your myelin, Part 1
I’m halfway through a 90-day trial of plasmalogens coincident with improving peroxisomal function via resistance exercise and time-restricted eating. I haven’t curated related 2023 papers I’ve read concerning plasmalogens, peroxisomes, sphingolipids, ceramides, and mitochondrial interactions with these, mainly because I haven’t seen human-pertinent aspects similar to Dr. Goodenowe’s efforts. The 2023 papers I’ve read have … Continue reading What you expect may not be what you find
Six 2023 papers on the subject, starting with a rodent study: “One of the primary discoveries of our study is that the endothelial cell (EC) transcriptome is dynamically regulated by both aging and heterochronic parabiosis. We found that ECs, when compared with other brain cell types, exhibited one of the highest fractions of aging-related genes … Continue reading Brain endothelial cells
A 2023 human / primate / rodent / worm study with 56 coauthors exhaustively investigated taurine effects: “We measured the blood concentration of taurine during aging and investigated the effect of taurine supplementation on healthspan and lifespan in several species. In C57Bl/6J wild-type (WT) mice, serum taurine concentrations declined from 132.3 ± 14.2 ng/ml at … Continue reading Taurine’s effects on healthspan and lifespan
Two 2023 reviews of Nrf2 and aging, starting with Nrf2-mitochondria interactions: “We discuss molecular mechanisms of interactions between Nrf2 and mitochondria that influence the rate of aging and lifespan. Nrf2 activity positively affects both mitochondrial dynamics and mitochondrial quality control. Nrf2 influences mitochondrial function through regulation of nuclear genome-encoded mitochondrial proteins and changes in the … Continue reading Nrf2 Week #4: Aging
Surface Your Real Self 