A better method of measuring neurogenesis

One of the references cited in Linking adult neurogenesis to Alzheimer’s disease was https://www.nature.com/articles/s41591-019-0375-9 “Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease” (not freely available). This 2019 Spanish human study used improved techniques to find: “Adult hippocampal neurogenesis (AHN), confers an unparalleled degree of plasticity to … Continue reading A better method of measuring neurogenesis

Linking adult neurogenesis to Alzheimer’s disease

This 2019 Spanish human study compared DNA methylation, chromatin and histone modifications in the hippocampus of deceased Alzheimer’s disease patients with controls: “A significant percentage of the differentially methylated genes were related to neural development and neurogenesis. It was astounding that other biological, cellular, and molecular processes generally associated with neurodegeneration such as apoptosis, autophagy, … Continue reading Linking adult neurogenesis to Alzheimer’s disease

Sleep and adult brain neurogenesis

This 2018 Japan/Detroit review subject was the impact of sleep and epigenetic modifications on adult dentate gyrus neurogenesis: “We discuss the functions of adult‐born DG neurons, describe the epigenetic regulation of adult DG neurogenesis, identify overlaps in how sleep and epigenetic modifications impact adult DG neurogenesis and memory consolidation.. Whereas the rate of DG neurogenesis … Continue reading Sleep and adult brain neurogenesis

PNAS politics in the name of science

This 2019 Germany/Canada human fetal cell study was a Proceedings of the National Academy of Sciences of the United States of America direct submission: “In a human hippocampal progenitor cell line, we assessed the short- and long-term effects of GC [glucocorticoid] exposure during neurogenesis on messenger RNA expression and DNA methylation profiles. Our data suggest … Continue reading PNAS politics in the name of science

A mid-year selection of epigenetic topics

Here are the most popular of the 65 posts I’ve made so far in 2018, starting from the earliest: The pain societies instill into children DNA methylation and childhood adversity Epigenetic mechanisms of muscle memory Sex-specific impacts of childhood trauma Sleep and adult brain neurogenesis This dietary supplement is better for depression symptoms than placebo … Continue reading A mid-year selection of epigenetic topics

An emotional center of our brains

This 2018 McGill/UC San Diego rodent study subject was the dentate gyrus area of the hippocampus: “Early life experience influences stress reactivity and mental health through effects on cognitive-emotional functions that are, in part, linked to gene expression in the dorsal and ventral hippocampus. The hippocampal dentate gyrus (DG) is a major site for experience-dependent … Continue reading An emotional center of our brains

A gaping hole in a review of nutritional psychiatry

This December 2016 Australian review published in September 2017 concerned: “..the nutritional psychiatry field..the neurobiological mechanisms likely modulated by diet, the use of dietary and nutraceutical interventions in mental disorders, and recommendations for further research.” The reviewers inexplicably omitted acetyl-L-carnitine, which I first covered in A common dietary supplement that has rapid and lasting antidepressant … Continue reading A gaping hole in a review of nutritional psychiatry

Use it or lose it: the interplay of new brain cells, age, and activity

This 2015 German review was of aging and activity in the context of adult neurogenesis: “Adult neurogenesis might be of profound functional significance because it occurs at a strategic bottleneck location in the hippocampus. Age-dependent changes essentially reflect a unidirectional development in that everything builds on what has occurred before. In this sense, aging can … Continue reading Use it or lose it: the interplay of new brain cells, age, and activity

The mystery of humans’ evolved capability for adults to grow new brain cells

This 2016 German review discussed the evolution of human adult neurogenesis: “Mammalian adult hippocampal neurogenesis is a trait shaped by evolutionary forces that have contributed to the advantages in natural selection that are associated with the mammalian dentate gyrus. Adult hippocampal neurogenesis in mammals originates from an ectopic precursor cell population that resides in a … Continue reading The mystery of humans’ evolved capability for adults to grow new brain cells

A molecular study of the epigenetic regulation of memory

This 2015 Norwegian rodent study provided: “New insights into the molecular underpinnings of synaptic plasticity. We report the first global transcriptome [all RNA found in specific cells] analysis of in vivo synaptic plasticity, using the well-established model of LTP [long-term potentiation, an increase in synaptic strength that underlies memory] in the rat dentate gyrus [a … Continue reading A molecular study of the epigenetic regulation of memory