Search Results for: neurogenesis

A better method of measuring neurogenesis

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One of the references cited in Linking adult neurogenesis to Alzheimer’s disease was https://www.nature.com/articles/s41591-019-0375-9 “Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease” (not freely available). This 2019 Spanish human study used improved techniques to find: “Adult hippocampal neurogenesis (AHN), confers an unparalleled degree of plasticity to … Continue reading A better method of measuring neurogenesis

Linking adult neurogenesis to Alzheimer’s disease

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This 2019 Spanish human study compared DNA methylation, chromatin and histone modifications in the hippocampus of deceased Alzheimer’s disease patients with controls: “A significant percentage of the differentially methylated genes were related to neural development and neurogenesis. It was astounding that other biological, cellular, and molecular processes generally associated with neurodegeneration such as apoptosis, autophagy, … Continue reading Linking adult neurogenesis to Alzheimer’s disease

Sleep and adult brain neurogenesis

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This 2018 Japan/Detroit review subject was the impact of sleep and epigenetic modifications on adult dentate gyrus neurogenesis: “We discuss the functions of adult‐born DG neurons, describe the epigenetic regulation of adult DG neurogenesis, identify overlaps in how sleep and epigenetic modifications impact adult DG neurogenesis and memory consolidation.. Whereas the rate of DG neurogenesis … Continue reading Sleep and adult brain neurogenesis

Lifespan Uber Correlation

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This 2022 study developed new epigenetic clocks: “Maximum lifespan is deemed to be a stable trait in species. The rate of biological function decline (i.e., aging) would be expected to correlate inversely with maximum species lifespan. Although aging and maximum lifespan are intimately intertwined, they nevertheless appear in some investigations to be distinct processes. Some … Continue reading Lifespan Uber Correlation

Gut microbiota topics

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Here are thirty 2019 and 2020 papers related to Switch on your Nrf2 signaling pathway topics. Started gathering research on this particular theme three months ago. There are more researchers alive today than in the sum of all history, and they’re publishing. I can’t keep up with the torrent of interesting papers. 2020 A prebiotic … Continue reading Gut microbiota topics

Nano-sulforaphane vs. barbecue chemicals

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This 2020 chicken study investigated the capability of nano-sulforaphane to protect embryonic survival and neurogenesis from a barbecued meat chemical: “Common teratogenic [of, relating to, or causing malformations of an embryo or a fetus] factors related to the development of the nervous system, such as alcohol consumption and smoking, have attracted wide attention. Teratogenic factors … Continue reading Nano-sulforaphane vs. barbecue chemicals

Upgrade your brain’s switchboard with broccoli sprouts

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Further investigating A claim of improved cognitive function, Part 3 of Rejuvenation therapy and sulforaphane offered: “Improving brain function does not depend on neurogenesis as much as it does on synapse formation and factors such as NMDA receptors which decline in density with age.” A PubMed “sulforaphane NMDA receptors” search turned up a 2019 cell … Continue reading Upgrade your brain’s switchboard with broccoli sprouts

Reevaluate findings in another paradigm

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It’s challenging for people to change their framework when their paychecks or mental state or reputations depend on it not changing. I’ll use The hypothalamus and aging as an example. This review was alright for partial fact-finding up through 2018. Its facts were limited, however, to what fit into the reviewers’ paradigm. The 2015 An … Continue reading Reevaluate findings in another paradigm

Part 3 of Rejuvenation therapy and sulforaphane

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Part 1 focused on the study’s clinical biomarkers. Part 2 highlighted its epigenetic clocks. Now we’ll look at rejuvenation of cognitive function. Charts for this study’s most relevant human aging applications – measured by the new human-rat relative biological age clock – were in supplementary data due to combining study untreated tissue samples into clock … Continue reading Part 3 of Rejuvenation therapy and sulforaphane

Prenatal stress heightened adult chronic pain

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This 2019 McGill rodent study found: “Prenatal stress exacerbates pain after injury. Analysis of mRNA expression of genes related to epigenetic regulation and stress responses in the frontal cortex and hippocampus, brain structures implicated in chronic pain, showed distinct sex and region-specific patterns of dysregulation. In general, mRNA expression was most frequently altered in the … Continue reading Prenatal stress heightened adult chronic pain

Do genes or maternal environments shape fetal brains?

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This 2019 Singapore human study used Diffusion Tensor Imaging on 5-to-17-day old infants to find: “Our findings showed evidence for region-specific effects of genotype and GxE on individual differences in human fetal development of the hippocampus and amygdala. Gene x Environment models outcompeted models containing genotype or environment only, to best explain the majority of … Continue reading Do genes or maternal environments shape fetal brains?

PNAS politics in the name of science

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This 2019 Germany/Canada human fetal cell study was a Proceedings of the National Academy of Sciences of the United States of America direct submission: “In a human hippocampal progenitor cell line, we assessed the short- and long-term effects of GC [glucocorticoid] exposure during neurogenesis on messenger RNA expression and DNA methylation profiles. Our data suggest … Continue reading PNAS politics in the name of science

A mid-year selection of epigenetic topics

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Here are the most popular of the 65 posts I’ve made so far in 2018, starting from the earliest: The pain societies instill into children DNA methylation and childhood adversity Epigenetic mechanisms of muscle memory Sex-specific impacts of childhood trauma Sleep and adult brain neurogenesis This dietary supplement is better for depression symptoms than placebo … Continue reading A mid-year selection of epigenetic topics

An emotional center of our brains

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This 2018 McGill/UC San Diego rodent study subject was the dentate gyrus area of the hippocampus: “Early life experience influences stress reactivity and mental health through effects on cognitive-emotional functions that are, in part, linked to gene expression in the dorsal and ventral hippocampus. The hippocampal dentate gyrus (DG) is a major site for experience-dependent … Continue reading An emotional center of our brains

A gaping hole in a review of nutritional psychiatry

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This December 2016 Australian review published in September 2017 concerned: “..the nutritional psychiatry field..the neurobiological mechanisms likely modulated by diet, the use of dietary and nutraceutical interventions in mental disorders, and recommendations for further research.” The reviewers inexplicably omitted acetyl-L-carnitine, which I first covered in A common dietary supplement that has rapid and lasting antidepressant … Continue reading A gaping hole in a review of nutritional psychiatry