Eight 2023 acetyl-L-carnitine / L-carnitine papers, starting with three healthy human studies: “Thirty healthy volunteers aged between 19 and 52 years were divided randomly into two equal groups, one of which received 1000 mg of L-carnitine (LC) per day over a 12-week period. Total cholesterol and HDL-C increased significantly after supplementation. LC could be useful … Continue reading Take acetyl-L-carnitine if you are healthy
A free educational series recorded in 2021-2022 available at https://drgoodenowe.com/dr-goodenowes-educational-seminars/ takes the viewer through underlying research and principles of Dr. Goodenowe’s approach to health. It’s advertised as lasting four hours, but took me two days to view. The series’ discussions and references are background material to better understand later presentations and interviews. Points of interest … Continue reading A good activity for bad weather days
Canadians were in dire straights yesterday, needing something to not be depressed about. It isn’t that US citizens are less depressed, but we have our Bill of Rights 1st and 2nd amendments that we adhere to. Several of the people on this three and a half hour conversation were Canadians. Will you listen to them? … Continue reading Canadian Thanksgiving
Six 2023 papers on the subject, starting with a rodent study: “One of the primary discoveries of our study is that the endothelial cell (EC) transcriptome is dynamically regulated by both aging and heterochronic parabiosis. We found that ECs, when compared with other brain cell types, exhibited one of the highest fractions of aging-related genes … Continue reading Brain endothelial cells
To follow the Nrf2 Week #2 finding that chromatin accessibility parallels Nrf2 expression, this 2023 cell study explored how Nrf2 influences other epigenetic processes: “We identified antioxidant response element sequences in promoter regions of genes encoding several epigenetic regulatory factors, such as histone deacetylases (HDACs), DNA methyltransferases (DNMTs), and proteins involved in microRNA biogenesis. We … Continue reading Nrf2 Week #3: Epigenetics
This 2022 study investigated brain aging: “We aimed to explore key genes underlying cognitively normal brain aging and its potential molecular mechanisms. Cellular and molecular mechanisms of brain aging are complex and mainly include: Dysfunction of mitochondria; Accumulation of oxidatively damaged proteins, nucleic acids, and lipids in brain cells; Disorders of energy metabolism; Impaired ‘waste … Continue reading Young immune system, young brain
This 2022 review explored the title subject: “Cell signaling imposes many demands on proteins that comprise these pathways, including abilities to form active and inactive states, and to engage in multiple protein interactions. Signaling often requires amplifying signals, regulating or tuning responses to signals, combining information sourced from multiple pathways, all while ensuring process fidelity. … Continue reading Signaling pathways and disordered proteins
This 2022 study developed new epigenetic clocks: “Maximum lifespan is deemed to be a stable trait in species. The rate of biological function decline (i.e., aging) would be expected to correlate inversely with maximum species lifespan. Although aging and maximum lifespan are intimately intertwined, they nevertheless appear in some investigations to be distinct processes. Some … Continue reading Lifespan Uber Correlation
This 2021 rodent study investigated aging’s effects: “We investigated aging consequences on temporal patterns of antioxidant defenses, molecular clock machinery, and blood pressure. We observed circadian rhythms of catalase (CAT) and glutathione peroxidase (GPx) mRNA expression, as well as ultradian rhythms of Nrf2 mRNA levels, in the hearts of young adult rats. We also found … Continue reading Nrf2 and circadian rhythm
This 2021 in vitro study investigated microRNAs as potential causative factors for broccoli’s beneficial effects: “A computational analysis was performed to explore processes and pathways associated with genes targeted either by: Host-expressed miRNAs (endogenous) modulated by bioactive compounds in broccoli; or miRNAs derived from broccoli (exogenous). miRNAs are noncoding RNAs containing between 19 and 24 … Continue reading Broccoli sprouts and microRNAs
This 2021 review subject was vasopressin: “Vasopressin is a ubiquitous molecule playing an important role in a wide range of physiological processes, thereby implicated in pathomechanisms of many disorders. The most striking is its central effect in stress-axis regulation, as well as regulating many aspects of our behavior. Arginine-vasopressin (AVP) is a nonapeptide that is … Continue reading All about vasopressin
This 2020 human cell study elaborated on mechanisms mentioned in Eat broccoli sprouts for your hearing and Sulforaphane in the Goldilocks zone: “NFE2L2/NRF2, a transcriptional factor that controls expression of multiple detoxifying enzymes through antioxidant response elements (AREs), is a target of sulforaphane (SFN). NFE2L2/NRF2 is a target gene of TFEB (transcription factor EB), a … Continue reading Precondition your defenses with broccoli sprouts
Two 2021 papers, both of which I found by each citing a 2009 Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane (not freely available). First was a review: “Hair cell damage and loss mediated by oxidative stress are important causes of hearing loss. Sensorineural hearing loss is the … Continue reading Eat broccoli sprouts for your hearing
This 2020 cell study investigated sulforaphane and three transcription pathways: “Novel findings of this study are: AMPK controls only a subset within the Nrf2-dependent transcriptome; Altered Nrf2 levels or altered accessibility of regulatory ARE sites do not account for observed differences in target gene transcription between used wt and AMPK −/− cells; Rather, AMPK presence/activity … Continue reading Part 3 of Broccoli sprouts activate the AMPK pathway
This 2020 rodent study investigated effects of different diets: “The present study aimed to evaluate effects of β-glucan on the microbiota gut-brain axis and cognitive function in an obese mouse model induced by a high-fat and fiber-deficient diet (HFFD). After long-term supplementation for 15 weeks, β-glucan prevented HFFD-induced cognitive impairment, assessed behaviorally by object location, novel … Continue reading Eat oats and regain cognitive normalcy
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