Reversal of aging and immunosenescent trends with sulforaphane

Sulforaphane research findings have commonalities with a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends. I did a PubMed search of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Presentation topics through the first 13 minutes were: Thymus – no recent sulforaphane studies … Continue reading Reversal of aging and immunosenescent trends with sulforaphane

Part 2 of rejuvenation therapy and sulforaphane

A rejuvenation therapy and sulforaphane focused on the study’s clinical biomarkers and not its biological age measurements. This Part 2 curation of the study highlights its epigenetic clocks because: “While clinical biomarkers have obvious advantages (being indicative of organ dysfunction or disease), they are neither sufficiently mechanistic nor proximal to fundamental mechanisms of aging to … Continue reading Part 2 of rejuvenation therapy and sulforaphane

An environmental signaling paradigm of aging

To follow up A rejuvenation therapy and sulforaphane, the study’s lead laboratory researcher provided evidence for an environmental signaling paradigm of aging in this 2015 paper: “The age-phenotype of a cell or organ depends on its environment and not its history. Organ dysfunction is not the cause of aging, but is the result of its … Continue reading An environmental signaling paradigm of aging

A rejuvenation therapy and sulforaphane

The founder of the epigenetic clock methodology with the coauthor of Aging as an unintended consequence released a 2020 rodent study “Reversing age: dual species measurement of epigenetic age with a single clock” at https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.pdf: “We employed six clocks to investigate the rejuvenation effects of a plasma fraction treatment in different rat tissues. Two of … Continue reading A rejuvenation therapy and sulforaphane

Week 6 of changing an inflammatory phenotype with broccoli sprouts

To follow up Week 5 of changing an inflammatory phenotype with broccoli sprouts: 1. I had an informative exchange with an author of Microwave broccoli to increase sulforaphane levels. The study provided an optimal sulforaphane end result of “(2.45 µmol/g DW)”. I asked a study author for additional data, and they replied: “The control GLR … Continue reading Week 6 of changing an inflammatory phenotype with broccoli sprouts

Broccoli sprouts oppose effects of advanced glycation end products (AGEs)

This 2020 Australian/UK review subject was AGEs: “AGEs are formed during cooking and food processing or produced endogenously as a consequence of metabolism. The deleterious effects of AGEs are underpinned by their ability to trigger mechanisms well known to elicit metabolic dysfunction, including the activation of inflammatory pathways, oxidative stress and impaired mitochondrial oxidative metabolism. … Continue reading Broccoli sprouts oppose effects of advanced glycation end products (AGEs)

Flatten the Panic Curve April 13-17, 2020

To better understand our internal origins of panic, here’s Dr. Arthur Janov’s interpretation of a 2013 Iowa study Fear and panic in humans with bilateral amygdala damage (not freely available): “Justin Feinstein did a study with those who had a damaged amygdala, the hub of the emotional system. They did not have normal fear responses. … Continue reading Flatten the Panic Curve April 13-17, 2020

US doctors incentivized to diagnose everything as COVID-19

To follow up Lowering US pneumonia death counts to increase COVID-19 death counts: “Dr. Scott Jensen, a Minnesota physician and Republican state senator, told a local station he received a 7-page document coaching him to fill out death certificates with a COVID-19 diagnosis without a lab test to confirm the patient actually had the virus. … Continue reading US doctors incentivized to diagnose everything as COVID-19

Lowering US pneumonia death counts to increase COVID-19 death counts

To follow up CDC directs the US to attribute deaths from other causes to COVID-19, my sending its information to Tucker Carlson yesterday morning may have contributed to the information being broadcast nationally yesterday evening. The transcript at Tucker Carlson: Possible That Doctors Are Classifying Conventional Pneumonia Deaths As COVID Deaths, Increasing The Count included: … Continue reading Lowering US pneumonia death counts to increase COVID-19 death counts

How much sulforaphane is suitable for healthy people?

This post compares and contrasts two perspectives on how much sulforaphane is suitable for healthy people. One perspective was an October 2019 review from John Hopkins researchers who specialize in sulforaphane clinical trials: Broccoli or Sulforaphane: Is It the Source or Dose That Matters? Since these researchers didn’t give a consumer-practical answer, I’ve presented a … Continue reading How much sulforaphane is suitable for healthy people?