Trained immunity genes

This 2021 human cell study investigated trained immunity responses: “We integrated genetic, epigenetic, and functional validation data to shed light on regulation of trained immunity responses. This data integration revealed a novel role of SIGLECs and KDM4 genes on trained immunity responses. Siglec-5 is an inhibitory receptor that dampens the immune response, and was found … Continue reading Trained immunity genes

Week 87 of Changing to a youthful phenotype with sprouts

This week I dialed back eating microwaved 3-day-old broccoli / red cabbage / mustard sprouts from twice a day to once a day. For my reasoning, here are two papers on broccoli sprouts and thyroid function, with the first a 2018 human study: “We analyzed biochemical measures of thyroid function and thyroid autoimmunity in a … Continue reading Week 87 of Changing to a youthful phenotype with sprouts

Eat broccoli sprouts for your liver

This 2021 rodent study investigated sulforaphane pretreatment’s role in reducing liver injuries: “As a double blood supply organ of the portal vein and artery, the liver is highly sensitive to ischemia, and is one of the common organs to suffer from hepatic ischemia-reperfusion injury (HI/RI). HI/RI leads to overproduction of reactive oxygen species (ROS). Overdoses … Continue reading Eat broccoli sprouts for your liver

Prevent your brain from shrinking

My 800th curation is a 2021 human diet and lifestyle study: “Brain atrophy is correlated with risk of cognitive impairment, functional decline, and dementia. This study (a) examines the statistical association between brain volume (BV) and age for Tsimane, and (b) compares this association to that of 3 industrialized populations in the United States and … Continue reading Prevent your brain from shrinking

Does sulforaphane treat autism?

A 2021 human study investigated sulforaphane treatments of autistic 3-to-12-year-olds: “Sulforaphane (SF) led to non-statistically significant changes in the total and all subscale scores of the primary outcome measure. Several effects of SF on biomarkers correlated to clinical improvements. SF was very well tolerated and safe and effective based on our secondary clinical measures. Clinical … Continue reading Does sulforaphane treat autism?

All about the betaine

A trio of papers on betaine, the first being a 2021 series of thorough rodent experiments relating betaine and gut microbiota, and cause and effect: “Compared with lean individuals, adipose tissues in obese individuals secrete high levels of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, inducing: Systemic inflammation; Insulin resistance; Large amounts of carcinogenic … Continue reading All about the betaine

Eat oats and regain cognitive normalcy

This 2020 rodent study investigated effects of different diets: “The present study aimed to evaluate effects of β-glucan on the microbiota gut-brain axis and cognitive function in an obese mouse model induced by a high-fat and fiber-deficient diet (HFFD). After long-term supplementation for 15 weeks, β-glucan prevented HFFD-induced cognitive impairment, assessed behaviorally by object location, novel … Continue reading Eat oats and regain cognitive normalcy

Does skin improvement cause overall effects?

This 2019 human skin study found: “We demonstrated in aged mice that epidermal dysfunction largely accounted for age-associated elevations in circulating cytokine levels, and that improving epidermal function reduced circulating cytokine levels. We performed a pilot study to determine whether improving epidermal function reduces circulating proinflammatory cytokine levels in aged humans. Both aged human and … Continue reading Does skin improvement cause overall effects?

Eat oats to prevent diabetes

This 2020 rodent study investigated Type 2 diabetics eating oats along with a bad diet: “Type 2 diabetes (T2D) is a metabolic disease which is characterized by a state of chronic low-grade inflammation with abnormal expression and production of multiple inflammatory mediators. Insulin resistance (IR), a condition where higher-than-normal concentration of insulin is needed to … Continue reading Eat oats to prevent diabetes

Treat your gut microbiota as one of your organs

Two 2021 reviews covered gut microbiota. The first was gut microbial origins of metabolites produced from our diets, and mutual effects: “Gut microbiota has emerged as a virtual endocrine organ, producing multiple compounds that maintain homeostasis and influence function of the human body. Host diets regulate composition of gut microbiota and microbiota-derived metabolites, which causes … Continue reading Treat your gut microbiota as one of your organs

Eat oats today!

This 2020 food chemistry review provided phenolic-compound reasons to eat oats: “Phenolamides result from the conjugation of hydroxycinnamic acids with amines. These products contain a variety of metabolic, chemical, and functional capabilities due to the large number of possible combinations among the parent compounds. Of the currently known phenolamides, the most common are avenanthramides (AVAs), … Continue reading Eat oats today!

Rub some broccoli sprouts on it

This 2020 human/rodent study investigated treating and preventing skin photodamage with sulforaphane: “Alterations in NRF2 signaling have been implicated in aging and stress-induced skin pigmentation disorders in the skin and hair follicles. NRF2 signaling regulates transcriptional programs involved in adaption and survival of cells in the setting of oxidative stress, and oxidative stress occurs in … Continue reading Rub some broccoli sprouts on it

Eat broccoli sprouts to pivot your internal environment’s signals

Two 2020 reviews covered some aspects of a broccoli sprouts primary action – NRF2 signaling pathway activation: “Full understanding of the properties of drug candidates rely partly on the identification, validation, and use of biomarkers to optimize clinical applications. This review focuses on results from clinical trials with four agents known to target NRF2 signaling … Continue reading Eat broccoli sprouts to pivot your internal environment’s signals

Sulforaphane clinical trials and COVID-19

A plethora of articles have been published this year on how researchers’ favorite topics can / may / should / could / will fix COVID-19. This one was different in that relevant clinical trials were both completed and already underway before a Madness of Crowds behavioral contagion infected us: “It is crucial to understand the … Continue reading Sulforaphane clinical trials and COVID-19

Autism biomarkers and sulforaphane

This 2020 US human study investigated autism improvements with sulforaphane: “Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders that, in the United States, is currently estimated to affect 1 out of 59 children who are 8 years old. Despite decades of research and advances in our knowledge of etiologies of ASD, … Continue reading Autism biomarkers and sulforaphane