A 2020 paper by the author of Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease:
“The gut and brain communicate bidirectionally via several pathways which include:
- Neural via the vagus nerve;
- Endocrine via the HPA axis;
- Neurotransmitters, some of which are synthesized by microbes;
- Immune via cytokines; and
- Metabolic via microbially generated short-chain fatty acids.
How does nature maintain the gut-microbiome-brain axis? Mechanisms to maintain homeostasis of intestinal epithelial cells and their underlying cells are a key consideration.
The symbiotic relationship that exists between microbiota and the human host is evident when considering nutrient requirements of each. The host provides food for microbes, which consume that food to produce metabolites necessary for health of the host.
https://www.sciencedirect.com/science/article/pii/B9780128205938000148 “Chapter 14 – The gut microbiome: its role in brain health” (not freely available)
Always more questions:
- What did you put into your gut today?
- What type of internal environment did it support?
- What “favorable impact on human health and behavior” do you expect from today’s intake?
- How will you feel?
- Will you let evidence guide feeding your gut environment?
See Harnessing endogenous defenses with broccoli sprouts for further elaboration. See Switch on your Nrf2 signaling pathway for an interview with these papers’ author.