Epigenetic effects of THC differ between female adolescents and adults

This 2017 Italian rodent study found: “THC [delta9-tetrahydrocannabinol, the psychoactive compound of cannabis] exposure affects histone modifications in the brain of female rats in a region- and age-specific manner. Specifically, THC acts on different targets depending on the considered brain area and, remarkably, the adolescent brain is generally more sensitive to THC than the adult … Continue reading Epigenetic effects of THC differ between female adolescents and adults

Epigenetic effects on genetic diseases

This 2017 review provided evidence for epigenetic effects on a disease widely considered to be of genetic origins: “..for a T1D [type 1 diabetes] identical twin the concordance rate (both twins affected)..is consistently less than 100%, which implies a non-genetically determined effect. However, the concordance rate declines with age at diagnosis of the index twin, … Continue reading Epigenetic effects on genetic diseases

Lack of oxygen’s epigenetic effects

This 2016 Finnish review’s subject was the epigenetic effects of hypoxia: “Ever since the Cambrian period, oxygen availability has been in the center of energy metabolism. Hypoxia stabilizes the expression of hypoxia-inducible transcription factor-1α (HIF-1α), which controls the expression of hundreds of survival genes related to enhanced energy metabolism and autophagy. There are several other … Continue reading Lack of oxygen’s epigenetic effects

Epigenetic contributions to hypertension

This 2016 Australian review subject was epigenetic contributions to hypertension: “Hypertension (HT) affects more than 1 billion people globally and is a major risk factor for stroke, chronic kidney disease, and myocardial infarction. Essential hypertension (EH) is a complex, polygenic condition with no single causative agent. There is increasing evidence that epigenetic modifications are as … Continue reading Epigenetic contributions to hypertension

What is epigenetic inheritance?

This 2016 review by Eric J. Nestler, a well-known and well-funded researcher, entitled Transgenerational Epigenetic Contributions to Stress Responses: Fact or Fiction? concluded: “Further work is needed to understand whether and to what extent true epigenetic inheritance of stress vulnerability adds to the well-established and powerful influence of genetics and environmental exposures in determining an … Continue reading What is epigenetic inheritance?

A study of how genetic factors determined diet-induced epigenetic changes

This 2016 California rodent study found: “HF [high fat] diet leads to persistent alterations of chromatin accessibility that are partially mediated by transcription factors and histone post-translational modifications. These chromatin alterations are furthermore strain specific, indicating a genetic component to the response. These results suggest that persistent epigenetic modifications induced by HF diet have the … Continue reading A study of how genetic factors determined diet-induced epigenetic changes

The epigenetic influence of obese parents at conception

This 2016 German rodent study found: “Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin–specific mode.” It would have benefited the researchers to have made the full study freely available. … Continue reading The epigenetic influence of obese parents at conception

Epigenetic regulation of natural killer cells

This 2016 German review focused on how epigenetic processes affected the natural killer cell part of the immune system: “Natural killer (NK) cells recognize and eliminate tumor- and virus-infected cells, parasites as well as certain types of bacteria. NK cell activity is related to a complex interaction of activating and inhibiting receptors on the NK … Continue reading Epigenetic regulation of natural killer cells

A review that inadvertently showed how memory paradigms prevented relevant research

This 2016 Swiss review of enduring memories demonstrated what happens when scientists’ reputations and paychecks interfered with them recognizing new research and evidence in their area but outside their paradigm: “A framework containing the basic assumptions, ways of thinking, and methodology that are commonly accepted by members of a scientific community.” 1. Most of the … Continue reading A review that inadvertently showed how memory paradigms prevented relevant research

Epigenetic memories of stress as therapeutic targets

This 2015 Swedish rodent study found: “Histone modifications induced by glucose are associated with activation of TXNIP gene [a proinflammatory gene involved in diabetic kidney disease] transcription. Glucose-stimulated TXNIP gene expression can be reversed by inhibition of histone acetyltransferase (HAT), or enhanced by inhibition of histone deacetylase (HDAC).” A 2016 Japanese commentary expounded on the … Continue reading Epigenetic memories of stress as therapeutic targets