Allergies and epigenetic histone modifications

This 2018 German review provided short summaries of 44 studies on the contribution of histone modifications to allergies. An overall summary of their search results was: “There are at least two levels at which the role of histone modifications is manifested. One is the regulation of cells that contribute to the allergic inflammation (T cells … Continue reading Allergies and epigenetic histone modifications

Nrf2 and Parkinson’s disease

This 2020 rodent study investigated a long non-coding RNA (lncRNA) in Parkinson’s disease: “Knockdown of MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) lncRNA inhibited elevated nuclear factor (erythroid-derived 2)-like-2 factor (NRF2) expression, thereby inhibiting inflammasome activation and ROS (reactive oxygen species) production. MALAT1 was shown to promote neuroinflammation by recruiting enhancer of zeste homologue 2 (EZH2) … Continue reading Nrf2 and Parkinson’s disease

Eat broccoli sprouts to pivot your internal environment’s signals

Two 2020 reviews covered some aspects of a broccoli sprouts primary action – NRF2 signaling pathway activation: “Full understanding of the properties of drug candidates rely partly on the identification, validation, and use of biomarkers to optimize clinical applications. This review focuses on results from clinical trials with four agents known to target NRF2 signaling … Continue reading Eat broccoli sprouts to pivot your internal environment’s signals

Jet fuel exposure causes diseases in the great-grand offspring

This 2020 Washington State University rodent study examined how great-grandmothers’ JP-8 exposures produced diseases in their great-grand offspring: “Ancestral exposure to environmental influences such as toxicants, abnormal nutrition, and traumatic stress can affect the germline epigenome and promote the epigenetic transgenerational inheritance of adult onset disease in various organisms from plants to humans. Biological mechanisms … Continue reading Jet fuel exposure causes diseases in the great-grand offspring

Get serious about advanced glycation end products (AGEs)

Ever heard about AGEs? Here are three papers that describe how AGEs affect humans. First is a 2020 Italian review Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System: “Neurodegenerative disease is an umbrella term for different conditions which primarily affect the neurons in the human brain. Currently, … Continue reading Get serious about advanced glycation end products (AGEs)

Transgenerational epigenetic inheritance of epimutations

My 600th curation is a 2020 rodent study from Dr. Michael Skinner’s labs at Washington State University: “Numerous environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of disease and phenotypic variation. Alterations in the germline epigenome are necessary to transmit transgenerational phenotypes. In previous studies, the pesticide DDT and the agricultural fungicide … Continue reading Transgenerational epigenetic inheritance of epimutations

Take responsibility for your one precious life – β glucan

From the main page of https://www.betaglucan.org/, a compilation for researchers: “Beta Glucan extracted from yeast cell wall, can be a potent immune response potentiator and modulator. A common test to determine a glucan’s immune response potentiation effectiveness is the measure of the degree to which a glucan increases the nitric oxide burst, a pathogen killing … Continue reading Take responsibility for your one precious life – β glucan

Day 70 results from Changing to a youthful phenotype with broccoli sprouts

Here are my Day 70 measurements* to follow up Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts, which had these findings: Keep in mind that I’m not in the population represented by the clinical trial sample: My chronological age is above their inclusion range; My BMI is below their inclusion … Continue reading Day 70 results from Changing to a youthful phenotype with broccoli sprouts

A review of sulforaphane and aging

This 2019 Mexican review stated: “We describe some of the molecular and physical characteristics of SFN, its mechanisms of action, and the effects that SFN treatment induces in order to discuss its relevance as a ‘miraculous’ drug to prevent aging and neurodegeneration. SFN has been shown to modulate several cellular pathways in order to activate … Continue reading A review of sulforaphane and aging

Reversal of aging and immunosenescent trends with sulforaphane

Sulforaphane research findings have commonalities with a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends. I did a PubMed search of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Presentation topics through the first 13 minutes were: Thymus – no recent sulforaphane studies … Continue reading Reversal of aging and immunosenescent trends with sulforaphane

Linear thinking about biological age clocks

This 2020 review by a Hong Kong company’s researchers compared and contrasted measures of biological age: “More than a dozen aging clocks use molecular features to predict an organism’s age, each of them utilizing different data types and training procedures. We offer a detailed comparison of existing mouse and human aging clocks, discuss their technological … Continue reading Linear thinking about biological age clocks

Reviewing clinical trials of broccoli sprouts and their compounds

This 2020 Spanish review analyzed recent clinical trials that used broccoli sprouts and their compounds. Stringent criteria for study selection resulted in few trials being considered: “We reduced the timeframe to the last years, from 2012 to the present. We focused our work on the data of studies carried out with human adults with different … Continue reading Reviewing clinical trials of broccoli sprouts and their compounds

Eat broccoli sprouts today!

This 2020 Korean letter to a journal editor cited 23 recent papers in support of sulforaphane’s positive effects, mainly in anti-cancer treatments: “Gene expression is mediated by chromatin epigenetic changes, including DNA methylation, histone modifications, promoter-enhancer interactions, and non-coding RNA (microRNA and long non-coding RNA)-mediated regulation. Approximately 50% of all tumor suppressor genes are inactivated … Continue reading Eat broccoli sprouts today!

Masters of manipulating their host

This 2020 French review subject was parasitical influences on host epigenetic processes: “Parasites have become masters of manipulating their host cells, exploiting signaling, and metabolic pathways to hijack host gene expression to their own advantage. These intracellular parasites have developed a wide range of strategies that affect transcriptional machineries and epigenetic events in the host … Continue reading Masters of manipulating their host

Clearing out the 2019 queue of interesting papers

I’m clearing out the below queue of 27 studies and reviews I’ve partially read this year but haven’t taken the time to curate. I have a pesky full-time job that demands my presence elsewhere during the day. :-\ Should I add any of these back in? Let’s be ready for the next decade! Early life … Continue reading Clearing out the 2019 queue of interesting papers