This 2016 New York rodent study found: “Parental behavioural traits can be transmitted by non-genetic mechanisms to the offspring. We show that four anxiety/stress-reactive traits are transmitted via independent iterative-somatic and gametic epigenetic mechanisms across multiple generations. As the individual traits/pathways each have their own generation-dependent penetrance and gender specificity, the resulting cumulative phenotype is … Continue reading A limited study of parental transmission of anxiety/stress-reactive traits
This 2015 Swiss rodent study found: “Mitochondrial function in the nucleus accumbens, a brain region relevant for motivation and depression, is a critical mediating factor in the subordinate status displayed by high-anxious rats. Treatment with nicotinamide, an amide form of vitamin B3 that boosts mitochondrial respiration, into the NAc [nucleus accumbens] of high-anxious rats at … Continue reading Brain-region-specific energy metabolism affected the social competitiveness of highly-anxious rats
This 2015 Swedish rodent study found: “Women with polycystic ovary syndrome (PCOS) display high circulating androgen levels that may affect the fetus and increase the risk of mood disorders in offspring. Although clinical data are inconsistent, there are indications that androgens play a crucial role in behavior and mood regulation in females. Studies on the … Continue reading Fetal exposure to sex hormones and female anxiety
An interview with Jeff Link, the editor of Dr. Arthur Janov’s 2011 book “Life Before Birth: The Hidden Script that Rules Our Lives” with Ken Rose: “Even further confirmation for some of the views of Janov, that maybe weren’t widely accepted for a time, it’s new research now being done into memory and what a … Continue reading Leaky gates, anxiety, and grocery store trips without buying list items
This 2015 Wisconsin macaque study was another attempt to justify the school’s continuing captivity of thousands of monkeys. The researchers performed a study that – if its experimental design was truly informative for helping humans – could have been done with humans. A problem I saw in the news coverage was that the finding of: … Continue reading Are a child’s genes the causes for their anxiety?
This 2014 Harvard/Princeton research studied brain areas as people made choices among multiple good options: “Our results show that choice conflict can at least lead to substantial short-term anxiety, that this anxiety increases with the number and value of one’s options (potentially enhanced by time pressure), and that it is not attenuated by awareness of … Continue reading We feel anxious even when making a choice from multiple good options
I’ll curate this 2022 review of what’s known and unknown about our trillions of gut microbiota through its topic headings: “Most microbial taxa and species of the human microbiome are still unknown. Without revealing the identity of these microbes as a first step, we cannot appreciate their role in human health and diseases. A. Understanding … Continue reading Gut microbiota knowledge through 2021
This 2021 review subject was vasopressin: “Vasopressin is a ubiquitous molecule playing an important role in a wide range of physiological processes, thereby implicated in pathomechanisms of many disorders. The most striking is its central effect in stress-axis regulation, as well as regulating many aspects of our behavior. Arginine-vasopressin (AVP) is a nonapeptide that is … Continue reading All about vasopressin
Three papers on interactions of the virus and inflammatory bowel disease, beginning with a 2021 review: “Analysis signaling pathways of innate and adaptive immunity components during SARS-CoV-2 infection in IBD (inflammatory bowel disease) patients through a putative alternative route – the gastrointestinal tract, with virus attachment to ACE2 (angiotensin-converting enzyme 2) expressed on IECs (intestinal … Continue reading An IBD trigger?
This 2020 review subject was brain-bone crosstalk: “Multiple stress, mood and neurodegenerative brain disorders are associated with osteoporosis. Skeletal diseases display impaired brain development and function. Along with brain and bone pathologies, trauma events highlight strong interaction of both organs. While brain-derived molecules affecting bone include central regulators – transmitters of the sympathetic, parasympathetic and … Continue reading Your bones influence your brain
To further understand An overlooked gut microbiota product, a 2018 rodent study found: “Microbial metabolites short-chain fatty acids (SCFAs) have been implicated in gastrointestinal functional, neuroimmune regulation, and host metabolism, but their role in stress-induced behavioural and physiological alterations is poorly understood SCFAs are primarily derived from fermentation of dietary fibres, and play a pivotal … Continue reading One aspect of research on short-chain fatty acids
This 2019 rodent study investigated an inulin-type fructo-oligosaccharide (FOS): “The microbiota-gut-brain axis was used to investigate anti-depressive properties of FOS at the interface of gut microbiota. FOS was introduced via gavage to rats exposed to chronic unpredictable mild stress: FOS alleviated depression-like behaviors and repaired intestinal epithelia damages. FOS treatment lowered corticosterone level. FOS-induced modulation … Continue reading Can a prebiotic help you feel better?
Consider this a partial repost of Moral Fiber: “We are all self-reproducing bioreactors. We provide an environment for trillions of microbes, most of which cannot survive for long without the food, shelter and a place to breed that we provide. They inhabit us so thoroughly that not a single tissue in our body is sterile. … Continue reading How will you feel?
This 2020 review subject was carnitine, acetyl-L-carnitine, and its other molecular forms: “Carnitine is necessary to deliver long-chain fatty acids from cytosol into mitochondria. Carnitine homeostasis is maintained by diet and renal absorption, as only a small amount (about 25%) is obtained by endogenous biosynthesis. Defective fatty acid oxidation occurs with reduced intracellular levels of … Continue reading A case for carnitine supplementation
This 2020 Swiss review subject was potential glutathione therapies for stress: “We examine available data supporting a role for GSH levels and antioxidant function in the brain in relation to anxiety and stress-related psychopathologies. Several promising compounds could raise GSH levels in the brain by either increasing availability of its precursors or expression of GSH-regulating … Continue reading Treating psychopathological symptoms will somehow resolve causes?