A limited study of parental transmission of anxiety/stress-reactive traits

May 15, 2016July 22, 2019 gettingwell4 2-3 stars Required further work, Amygdala, Brain development, Epigenetics, Hippocampus, Immune system, Limbic system, Neurochemicals, Serotonin, Stress Brain neurons, DNA methylation, Embryo development, Empathy, Infants, Neural plasticity

This 2016 New York rodent study found: “Parental behavioural traits can be transmitted by non-genetic mechanisms to the offspring. We show that four anxiety/stress-reactive traits are transmitted via independent iterative-somatic and gametic epigenetic mechanisms across multiple generations. As the individual traits/pathways each have their own generation-dependent penetrance and gender specificity, the resulting cumulative phenotype is … Continue reading A limited study of parental transmission of anxiety/stress-reactive traits

Brain-region-specific energy metabolism affected the social competitiveness of highly-anxious rats

December 13, 2015May 20, 2019 gettingwell4 4-5 stars Advanced knowledge, Acetylcholine, Amygdala, Cerebrum, Cortisol, Dopamine, Epigenetics, Limbic system, Memory, Neurochemicals, Stress Brain neurons, Control group, Neural plasticity

This 2015 Swiss rodent study found: “Mitochondrial function in the nucleus accumbens, a brain region relevant for motivation and depression, is a critical mediating factor in the subordinate status displayed by high-anxious rats. Treatment with nicotinamide, an amide form of vitamin B3 that boosts mitochondrial respiration, into the NAc [nucleus accumbens] of high-anxious rats at … Continue reading Brain-region-specific energy metabolism affected the social competitiveness of highly-anxious rats

Fetal exposure to sex hormones and female anxiety

November 4, 2015May 21, 2019 gettingwell4 0-1 star Wasted resources, Amygdala, Brain development, Cortisol, Epigenetics, Glutamate, Hippocampus, Hypothalamus, Limbic system, Neurochemicals, Serotonin, Stress, Testosterone Embryo development

This 2015 Swedish rodent study found: “Women with polycystic ovary syndrome (PCOS) display high circulating androgen levels that may affect the fetus and increase the risk of mood disorders in offspring. Although clinical data are inconsistent, there are indications that androgens play a crucial role in behavior and mood regulation in females. Studies on the … Continue reading Fetal exposure to sex hormones and female anxiety

Leaky gates, anxiety, and grocery store trips without buying list items

September 21, 2015August 8, 2022 gettingwell4 4-5 stars Advanced knowledge, Brain development, Brainstem, Cerebrum, Cortisol, Dopamine, Epigenetics, Limbic system, Lower brain, Memory, Neurochemicals, Oxytocin, Primal Therapy, Serotonin, Stress Critical period, DNA methylation, Dr. Arthur Janov, Embryo development, Genetic factors, Neural plasticity, Prefrontal cortex, Unconscious feelings, Unconscious memories

An interview with Jeff Link, the editor of Dr. Arthur Janov’s 2011 book “Life Before Birth: The Hidden Script that Rules Our Lives” with Ken Rose: “Even further confirmation for some of the views of Janov, that maybe weren’t widely accepted for a time, it’s new research now being done into memory and what a … Continue reading Leaky gates, anxiety, and grocery store trips without buying list items

Are a child’s genes the causes for their anxiety?

July 25, 2015May 21, 2019 gettingwell4 0-1 star Wasted resources, Amygdala, Brain development, Brainstem, Cerebrum, Epigenetics, Limbic system, Lower brain, Stress Genetic factors, Infants, Inherited disease, Prefrontal cortex

This 2015 Wisconsin macaque study was another attempt to justify the school’s continuing captivity of thousands of monkeys. The researchers performed a study that – if its experimental design was truly informative for helping humans – could have been done with humans. A problem I saw in the news coverage was that the finding of: … Continue reading Are a child’s genes the causes for their anxiety?

We feel anxious even when making a choice from multiple good options

February 15, 2015May 21, 2019 gettingwell4 0-1 star Wasted resources, Cerebrum, Limbic system, Lower brain

This 2014 Harvard/Princeton research studied brain areas as people made choices among multiple good options: “Our results show that choice conflict can at least lead to substantial short-term anxiety, that this anxiety increases with the number and value of one’s options (potentially enhanced by time pressure), and that it is not attenuated by awareness of … Continue reading We feel anxious even when making a choice from multiple good options

Building your plasmalogen savings account

December 8, 2023January 6, 2024 gettingwell4 4-5 stars Advanced knowledge, Acetylcholine, Brain development, Cerebrum, Dopamine, Epigenetics, Immune system, Limbic system, Lower brain, Memory, Neurochemicals, Stress Brain neurons, Control group, Embryo development, Genetic factors, Infants, Neural plasticity, Neurodegenerative disease

A webinar from earlier this week with Dr. Goodenowe, a clinical trial facilitator, and a physician: From the Q&A segment: “Is there a particular age where it’s recommended to test for plasmalogen levels? And what levels would be considered normal? That’s a good question. That actually raises this whole concept of optimal health and this … Continue reading Building your plasmalogen savings account

Brain restoration with plasmalogens

November 20, 2023February 28, 2024 gettingwell4 5+ stars Premium, Acetylcholine, Amygdala, Anterior cingulate cortex, Beliefs, Brain development, Brain hemispheres, Brainstem, Cerebellum, Cerebrum, Dopamine, Epigenetics, Glutamate, Hippocampus, Hypothalamus, Limbic system, Locus coeruleus, Lower brain, Memory, Neurochemicals, Primal Therapy, Serotonin, Stress, Thalamus Brain neurons, Control group, Corpus callosum, Dr. Arthur Janov, Genetic factors, Levels of consciousness, Neural plasticity, Neurodegenerative disease, Prefrontal cortex, Unconscious feelings, Unconscious memories

In this 2023 presentation for a professional audience, Dr. Dayan Goodenowe showed an example of what could be done (in the form of what he personally did at ages 53-54) to restore and augment brain structure and function over a 17-month period by taking plasmalogens and supporting supplements: https://drgoodenowe.com/recording-of-dr-goodenowes-presentation-from-the-peptide-world-congress-2023-is-now-available/ Follow the video along with its … Continue reading Brain restoration with plasmalogens

Ergothioneine dosing

September 23, 2023March 31, 2024 gettingwell4 4-5 stars Advanced knowledge, Anterior cingulate cortex, Brainstem, Epigenetics, Hippocampus, Immune system, Limbic system, Lower brain, Memory, Stress Brain neurons, Control group, Genetic factors, Neurodegenerative disease, Prefrontal cortex

Four 2023 papers that outlined or used different ergothioneine doses, starting with a human/rodent study: “We found that cognitive function and hippocampal neurogenesis were lower in mice fed an ERGO-free diet than in those fed the control diet. Mice fed an ERGO-free diet were orally administered ERGO (0, 2, and 20 mg/kg) for two weeks … Continue reading Ergothioneine dosing

Adverse Childhood Experiences, Part 2

July 17, 2023July 18, 2023 gettingwell4 2-3 stars Required further work, Brain development, Cerebellum, Cerebrum, Epigenetics, Hippocampus, Limbic system, Lower brain, Memory, Stress Brain neurons, Critical period, DNA methylation, Embryo development, Empathy, Genetic factors, Infants

A request was made to present studies that investigated epigenetic impacts of corporal punishments or physical trauma to children or adolescents. Here’s a follow-on of the 2015 Grokking an Adverse Childhood Experiences (ACE) score, since physical abuse is one factor of an ACE score. 1. The largest problem is that a person filling out an … Continue reading Adverse Childhood Experiences, Part 2

Eat broccoli sprouts for depression, Part 3

March 13, 2023March 16, 2023 gettingwell4 4-5 stars Advanced knowledge, Cerebrum, Epigenetics, Hippocampus, Hypothalamus, Limbic system, Memory, Stress Brain neurons, Control group, Critical period, Genetic factors, Neural plasticity, Prefrontal cortex

Here are two papers published after Part 2 that cited the Part 1 rodent study, starting with a 2023 rodent study performed by several Part 1 coauthors: “We used a low-dose LPS-induced endotoxaemia model to mimic clinical characteristics of sepsis. We found that adolescent LPS treatment was sufficient to increase levels of inflammatory factor TNF-α … Continue reading Eat broccoli sprouts for depression, Part 3

What do we know about human aging from mouse models?

November 24, 2022November 24, 2022 gettingwell4 4-5 stars Advanced knowledge, Cortisol, Epigenetics, Hippocampus, Immune system, Limbic system, Memory, Neurochemicals, Stress Control group, Genetic factors, Neurodegenerative disease

Here is a 2021 rodent study and relevant parts from 3 of its 26 citing papers: “A long line of evidence has established the laboratory mouse as the prime model of human aging. However, relatively little is known about detailed behavioral and functional changes that occur across their lifespan, and how this maps onto the … Continue reading What do we know about human aging from mouse models?

Non-CpG methylation

July 16, 2022January 3, 2023 gettingwell4 4-5 stars Advanced knowledge, Amygdala, Cerebrum, Epigenetics, Hippocampus, Hypothalamus, Limbic system, Memory, Stress Antidepressants, Brain neurons, Control group, Critical period, DNA methylation, Genetic factors, Neurodegenerative disease, Prefrontal cortex

Three 2022 papers on methylation epigenetic modifiers, starting with a human study focused on mitochondrial DNA non-CpG methylation involving nucleobases other than guanine (arginine, cytosine, or thymine): “We collected brain tissue in the nucleus accumbens and prefrontal cortex from deceased individuals without (n = 39) and with (n = 14) drug use, and used whole-genome bisulfite sequencing to cover … Continue reading Non-CpG methylation

Gut microbiota knowledge through 2021

March 21, 2022January 3, 2023 gettingwell4 2-3 stars Required further work, Amygdala, Cortisol, Dopamine, Epigenetics, Glutamate, Hippocampus, Hypothalamus, Immune system, Limbic system, Memory, Neurochemicals, Oxytocin, Serotonin, Stress Antidepressants, Brain neurons, Control group, Genetic factors, Infants, Neurodegenerative disease, Prefrontal cortex, Reciprocity

I’ll curate this 2022 review of what’s known and unknown about our trillions of gut microbiota through its topic headings: “Most microbial taxa and species of the human microbiome are still unknown. Without revealing the identity of these microbes as a first step, we cannot appreciate their role in human health and diseases. A. Understanding … Continue reading Gut microbiota knowledge through 2021

All about vasopressin

September 12, 2021September 13, 2021 gettingwell4 4-5 stars Advanced knowledge, Amygdala, Brain development, Cerebrum, Cortisol, Dopamine, Epigenetics, Glutamate, Hippocampus, Hypothalamus, Limbic system, Memory, Neurochemicals, Oxytocin, Primal Therapy, Stress, Testosterone, Vasopressin Brain neurons, DNA methylation, Embryo development, Genetic factors, Infants, Neural plasticity, Neurodegenerative disease, Prefrontal cortex

This 2021 review subject was vasopressin: “Vasopressin is a ubiquitous molecule playing an important role in a wide range of physiological processes, thereby implicated in pathomechanisms of many disorders. The most striking is its central effect in stress-axis regulation, as well as regulating many aspects of our behavior. Arginine-vasopressin (AVP) is a nonapeptide that is … Continue reading All about vasopressin