Search Results for: anx

A limited study of parental transmission of anxiety/stress-reactive traits

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This 2016 New York rodent study found: “Parental behavioural traits can be transmitted by non-genetic mechanisms to the offspring. We show that four anxiety/stress-reactive traits are transmitted via independent iterative-somatic and gametic epigenetic mechanisms across multiple generations. As the individual traits/pathways each have their own generation-dependent penetrance and gender specificity, the resulting cumulative phenotype is … Continue reading A limited study of parental transmission of anxiety/stress-reactive traits

Brain-region-specific energy metabolism affected the social competitiveness of highly-anxious rats

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This 2015 Swiss rodent study found: “Mitochondrial function in the nucleus accumbens, a brain region relevant for motivation and depression, is a critical mediating factor in the subordinate status displayed by high-anxious rats. Treatment with nicotinamide, an amide form of vitamin B3 that boosts mitochondrial respiration, into the NAc [nucleus accumbens] of high-anxious rats at … Continue reading Brain-region-specific energy metabolism affected the social competitiveness of highly-anxious rats

Fetal exposure to sex hormones and female anxiety

gettingwell4 0-1 star Wasted resources, Amygdala, Brain development, Cortisol, Epigenetics, Glutamate, Hippocampus, Hypothalamus, Limbic system, Neurochemicals, Serotonin, Stress, Testosterone

This 2015 Swedish rodent study found: “Women with polycystic ovary syndrome (PCOS) display high circulating androgen levels that may affect the fetus and increase the risk of mood disorders in offspring. Although clinical data are inconsistent, there are indications that androgens play a crucial role in behavior and mood regulation in females. Studies on the … Continue reading Fetal exposure to sex hormones and female anxiety

Leaky gates, anxiety, and grocery store trips without buying list items

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An interview with Jeff Link, the editor of Dr. Arthur Janov’s 2011 book “Life Before Birth: The Hidden Script that Rules Our Lives” with Ken Rose: “Even further confirmation for some of the views of Janov, that maybe weren’t widely accepted for a time, it’s new research now being done into memory and what a … Continue reading Leaky gates, anxiety, and grocery store trips without buying list items

Are a child’s genes the causes for their anxiety?

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This 2015 Wisconsin macaque study was another attempt to justify the school’s continuing captivity of thousands of monkeys. The researchers performed a study that – if its experimental design was truly informative for helping humans – could have been done with humans. A problem I saw in the news coverage was that the finding of: … Continue reading Are a child’s genes the causes for their anxiety?

We feel anxious even when making a choice from multiple good options

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This 2014 Harvard/Princeton research studied brain areas as people made choices among multiple good options: “Our results show that choice conflict can at least lead to substantial short-term anxiety, that this anxiety increases with the number and value of one’s options (potentially enhanced by time pressure), and that it is not attenuated by awareness of … Continue reading We feel anxious even when making a choice from multiple good options

Eat broccoli sprouts for depression, Part 3

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Here are two papers published after Part 2 that cited the Part 1 rodent study, starting with a 2023 rodent study performed by several Part 1 coauthors: “We used a low-dose LPS-induced endotoxaemia model to mimic clinical characteristics of sepsis. We found that adolescent LPS treatment was sufficient to increase levels of inflammatory factor TNF-α … Continue reading Eat broccoli sprouts for depression, Part 3

What do we know about human aging from mouse models?

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Here is a 2021 rodent study and relevant parts from 3 of its 26 citing papers: “A long line of evidence has established the laboratory mouse as the prime model of human aging. However, relatively little is known about detailed behavioral and functional changes that occur across their lifespan, and how this maps onto the … Continue reading What do we know about human aging from mouse models?

Non-CpG methylation

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Three 2022 papers on methylation epigenetic modifiers, starting with a human study focused on mitochondrial DNA non-CpG methylation involving nucleobases other than guanine (arginine, cytosine, or thymine): “We collected brain tissue in the nucleus accumbens and prefrontal cortex from deceased individuals without (n = 39) and with (n = 14) drug use, and used whole-genome bisulfite sequencing to cover … Continue reading Non-CpG methylation

Gut microbiota knowledge through 2021

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I’ll curate this 2022 review of what’s known and unknown about our trillions of gut microbiota through its topic headings: “Most microbial taxa and species of the human microbiome are still unknown. Without revealing the identity of these microbes as a first step, we cannot appreciate their role in human health and diseases. A. Understanding … Continue reading Gut microbiota knowledge through 2021

All about vasopressin

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This 2021 review subject was vasopressin: “Vasopressin is a ubiquitous molecule playing an important role in a wide range of physiological processes, thereby implicated in pathomechanisms of many disorders. The most striking is its central effect in stress-axis regulation, as well as regulating many aspects of our behavior. Arginine-vasopressin (AVP) is a nonapeptide that is … Continue reading All about vasopressin

An IBD trigger?

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Three papers on interactions of the virus and inflammatory bowel disease, beginning with a 2021 review: “Analysis signaling pathways of innate and adaptive immunity components during SARS-CoV-2 infection in IBD (inflammatory bowel disease) patients through a putative alternative route – the gastrointestinal tract, with virus attachment to ACE2 (angiotensin-converting enzyme 2) expressed on IECs (intestinal … Continue reading An IBD trigger?

Your bones influence your brain

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This 2020 review subject was brain-bone crosstalk: “Multiple stress, mood and neurodegenerative brain disorders are associated with osteoporosis. Skeletal diseases display impaired brain development and function. Along with brain and bone pathologies, trauma events highlight strong interaction of both organs. While brain-derived molecules affecting bone include central regulators – transmitters of the sympathetic, parasympathetic and … Continue reading Your bones influence your brain

One aspect of research on short-chain fatty acids

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To further understand An overlooked gut microbiota product, a 2018 rodent study found: “Microbial metabolites short-chain fatty acids (SCFAs) have been implicated in gastrointestinal functional, neuroimmune regulation, and host metabolism, but their role in stress-induced behavioural and physiological alterations is poorly understood SCFAs are primarily derived from fermentation of dietary fibres, and play a pivotal … Continue reading One aspect of research on short-chain fatty acids

Can a prebiotic help you feel better?

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This 2019 rodent study investigated an inulin-type fructo-oligosaccharide (FOS): “The microbiota-gut-brain axis was used to investigate anti-depressive properties of FOS at the interface of gut microbiota. FOS was introduced via gavage to rats exposed to chronic unpredictable mild stress: FOS alleviated depression-like behaviors and repaired intestinal epithelia damages. FOS treatment lowered corticosterone level. FOS-induced modulation … Continue reading Can a prebiotic help you feel better?