The coauthor of:
- A self-referencing study of transgenerational epigenetic inheritance; and
- A review of epigenetic transgenerational inheritance of reproductive disease
pointed out the opportunity for the researchers of A seasonal epigenetic effect of conception on BMI to have their work make a difference in their field:
Future studies are now needed to determine whether the cold-induced thrifty metabolic phenotype is transmitted to subsequent generations. If exposure not only impacts the health of offspring, but also of all subsequent generations, the impact is significant.”
Every human alive today has observable lasting epigenetic effects caused by environmental factors:
- During the earliest parts of our lives;
- From our parents’ exposures and experiences before we’re conceived – many of which are inadequately researched; and
- Potentially from some of our earlier ancestors’ exposures and experiences.
Aren’t animal studies’ evidence for epigenetic transgenerational inheritance sufficient to compel serious human follow-on research efforts by research sponsors and study designers? The same comments about epigenetic effects caused by temperature potentially inherited by multiple human generations can also be made about other environmental factors, such as:
- Toxins – the commentator’s usual area of study, and
I hope that these researchers value their professions enough to make a difference with this or other areas of their expertise. And that sponsors won’t thwart researchers’ desires for difference-making science by putting them into endless funding queues.
https://www.nature.com/articles/s41591-018-0187-3 “Preconception cold–induced epigenetic inheritance” (not freely available)