Search Results for: phenotyp

Epigenetic transgenerational inheritance of ovarian disease

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This 2018 Washington rodent study investigated ovarian disease in F3 great-granddaughters caused by their F0 great-grandmothers’ exposures to DDT or vinclozolin while pregnant: “Two of the most prevalent ovarian diseases affecting women’s fertility and health are Primary Ovarian Insufficiency (POI) and Polycystic Ovarian Syndrome (PCOS). POI is characterized by a marked reduction in the primordial … Continue reading Epigenetic transgenerational inheritance of ovarian disease

The imperative of human transgenerational studies

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The coauthor of: A self-referencing study of transgenerational epigenetic inheritance; and A review of epigenetic transgenerational inheritance of reproductive disease pointed out the opportunity for the researchers of A seasonal epigenetic effect of conception on BMI to have their work make a difference in their field: “The ability of environmental epigenetics to promote an adaptive … Continue reading The imperative of human transgenerational studies

Reversing epigenetic changes with CRISPR/Cas9

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This 2018 Chinese review highlighted areas in which CRISPR/Cas9 technology has, is, and could be applied to rewrite epigenetic changes: “CRISPR/Cas9-mediated epigenome editing holds a great promise for epigenetic studies and therapeutics. It could be used to selectively modify epigenetic marks at a given locus to explore mechanisms of how targeted epigenetic alterations would affect … Continue reading Reversing epigenetic changes with CRISPR/Cas9

Organ epigenetic memory

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This 2018 Japanese review subject was the relationships of organ memory and non-communicable diseases: “Organ memory is the engraved phenotype of altered organ responsiveness acquired by a time-dependent accumulation of organ stress responses. This phenomenon is known as “metabolic memory” or “legacy effect,” which is similar to neuronal and immune memory. Not only is the … Continue reading Organ epigenetic memory

Hidden hypotheses of epigenetic studies

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This 2018 UK review discussed three pre-existing conditions of epigenetic genome-wide association studies: “Genome-wide technology has facilitated epigenome-wide association studies (EWAS), permitting ‘hypothesis-free’ examinations in relation to adversity and/or mental health problems. Results of EWAS are in fact conditional on several a priori hypotheses: EWAS coverage is sufficient for complex psychiatric problems; Peripheral tissue is … Continue reading Hidden hypotheses of epigenetic studies

Restoration of a “normal” epigenetic landscape

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This 2018 Texas human review subject was prostate cancer epigenetics: “We comprehensively review the up-to-date roles of epigenetics in the development and progression of prostate cancer. We especially focus on three epigenetic mechanisms: DNA methylation, histone modifications, and noncoding RNAs. We elaborate on current models/theories that explain the necessity of these epigenetic programs in driving … Continue reading Restoration of a “normal” epigenetic landscape

Measuring epigenetic changes at a single-cell level

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This 2018 Canadian cell study described the development of a single-cell protocol to: “Profile primitive hematopoietic cells of mouse and human origin to identify epigenetically distinct subpopulations. Deep sampling of the CpG content of individual HSCs allowed for the near complete reconstitution of regulatory states from epigenetically defined subpopulations of HSCs and revealed a high … Continue reading Measuring epigenetic changes at a single-cell level

Epigenetic effects of breast cancer treatments

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This 2018 UC San Diego review subject was the interplay between breast cancer treatments and their effects on aging: “Although current breast cancer treatments are largely successful in producing cancer remission and extending lifespan, there is concern that these treatments may have long lasting detrimental effects on cancer survivors, in part, through their impact on … Continue reading Epigenetic effects of breast cancer treatments

Allergies and epigenetic histone modifications

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This 2018 German review provided short summaries of 44 studies on the contribution of histone modifications to allergies. An overall summary of their search results was: “There are at least two levels at which the role of histone modifications is manifested. One is the regulation of cells that contribute to the allergic inflammation (T cells … Continue reading Allergies and epigenetic histone modifications

Epigenetic variations in metabolism

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This 2018 German review was comprehensive for its subject, epigenetic control of variation and stochasticity in metabolic disease. I’ll focus on one aspect, phenotypic variation: “Phenotypic [Mendelian] variation can result both from gain- and loss-of-function mutations. Because of the extreme interconnectivity of cell regulatory networks, even at the cellular level, predicting the impact of a … Continue reading Epigenetic variations in metabolism