Search Results for: transgenerational

Transgenerational epigenetic effects of maternal obesity during pregnancy

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This 2018 Belgian review subject was in part the transgenerational epigenetic effects of maternal obesity during pregnancy. The subject was tailored for the journal in which it appeared, Atherosclerosis, so other transgenerationally inherited epigenetic effects weren’t reviewed: “The transgenerational impact of these alterations in methylation patterns are only shown in animal studies with HFD [high-fat … Continue reading Transgenerational epigenetic effects of maternal obesity during pregnancy

A self-referencing study of transgenerational epigenetic inheritance

gettingwell4 2-3 stars Needed further work, Amygdala, Epigenetics, Hippocampus, Limbic system, Memory, Stress , , ,

This 2018 Washington rodent study subject was transgenerational epigenetic inheritance caused by a fungicide that’s been phased out or banned for over a decade: “This study was designed to help understand how three different epigenetic processes in sperm are correlated with vinclozolin-induced epigenetic transgenerational inheritance of disease. Most DMRs [differential DNA-methylated regions] identified in this … Continue reading A self-referencing study of transgenerational epigenetic inheritance

Transgenerationally inherited epigenetic effects of fetal alcohol exposure

gettingwell4 2-3 stars Needed further work, Acetylecholine, Brain development, Cerebrum, Epigenetics, Hippocampus, Limbic system, Memory, Neurochemicals , , , , , , ,

The fourth paper of Transgenerational epigenetic inheritance week was a 2016 German rodent study of transgenerational epigenetic effects of alcohol: “We investigated 2 generations of offspring born to alcohol-treated mothers. Here, we show that memory impairment and reduced synthesis of acetylcholine occurs in both F1 (exposed to ethanol in utero) and F2 generation (never been exposed to … Continue reading Transgenerationally inherited epigenetic effects of fetal alcohol exposure

Transgenerational pathological traits induced by prenatal immune activation

gettingwell4 2-3 stars Needed further work, Amygdala, Brain development, Epigenetics, Glutamate, Immune system, Limbic system, Neurochemicals, Stress , , , , , , ,

The third paper of Transgenerational epigenetic inheritance week was a 2016 Swiss rodent study of immune system epigenetic effects: “Our study demonstrates for, we believe, the first time that prenatal immune activation can negatively affect brain and behavioral functions in multiple generations. These findings thus highlight a novel pathological aspect of this early-life adversity in shaping … Continue reading Transgenerational pathological traits induced by prenatal immune activation

Experience-induced transgenerational programming of neuronal structure and functions

gettingwell4 2-3 stars Needed further work, Amygdala, Anterior cingulate cortex, Brain development, Brainstem, Cerebrum, Cortisol, Dopamine, Epigenetics, Glutamate, Hippocampus, Hypothalamus, Limbic system, Locus coeruleus, Lower brain, Memory, Neurochemicals, Oxytocin, Serotonin, Stress , , , , , , , , , , , ,

The second paper of Transgenerational epigenetic inheritance week was a 2017 German/Israeli review focused on: “The inter- and transgenerational effects of stress experience prior to and during gestation..the concept of stress-induced (re-)programming in more detail by highlighting epigenetic mechanisms and particularly those affecting the development of monoaminergic transmitter systems, which constitute the brain’s reward system..we offer … Continue reading Experience-induced transgenerational programming of neuronal structure and functions

Transgenerational effects of early environmental insults on aging and disease

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The first paper of Transgenerational epigenetic inheritance week was a 2017 Canadian/Netherlands review that’s organized as follows: “First, we address mechanisms of developmental and transgenerational programming of disease and inheritance. Second, we discuss experimental and clinical findings linking early environmental determinants to adverse aging trajectories in association with possible parental contributions and sex-specific effects. Third, we … Continue reading Transgenerational effects of early environmental insults on aging and disease

It’s transgenerational epigenetic inheritance week!

gettingwell4 4-5 stars Advanced knowledge, Brain development, Cerebrum, Epigenetics, Immune system, Limbic system, Lower brain, Memory, Neurochemicals, Stress , , , ,

Transgenerational epigenetic inheritance is a subject whose time has come. This week I sequentially curated two 2017 reviews and two 2016 studies of the subject, and ended with a meta-analysis of human preventive treatments: Transgenerational effects of early environmental insults on aging and disease Experience-induced transgenerational programming of neuronal structure and functions Transgenerational pathological traits … Continue reading It’s transgenerational epigenetic inheritance week!

A review of epigenetic transgenerational inheritance of reproductive disease

gettingwell4 2-3 stars Needed further work, Brain development, Epigenetics, Stress , , , ,

This 2015 Washington review of epigenetic transgenerational inheritance of reproductive disease defined transgenerational effects as follows: “In considering transgenerational phenomena it is important to distinguish between direct exposure effects versus germline (sperm or egg) mediated transgenerational events. When a gestating F0 generation female is exposed the F0 generation female, the F1 generation fetus and the … Continue reading A review of epigenetic transgenerational inheritance of reproductive disease

Transgenerational epigenetic programming with stress and microRNA

gettingwell4 4-5 stars Advanced knowledge, Brain development, Cortisol, Epigenetics, Hypothalamus, Limbic system, Neurochemicals, Stress , , , , ,

This 2015 Pennsylvania rodent study found: “Sperm miRs [microRNAs, a small non-coding RNA that has a role in gene expression] function to reduce maternal mRNA [messenger RNA, a large RNA that carries codes for protein production] stores in early zygotes, ultimately reprogramming gene expression in the offspring hypothalamus and recapitulating the offspring stress dysregulation phenotype.” … Continue reading Transgenerational epigenetic programming with stress and microRNA

A book review of “Neuroepigenetics and Mental Illness”

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A 2018 online book “Neuroepigenetics and Mental Illness” was published at https://www.sciencedirect.com/bookseries/progress-in-molecular-biology-and-translational-science/vol/158/suppl/C (not freely available). Three chapters are reviewed here, with an emphasis on human studies. “Chapter Five: Neuroepigenetics of Prenatal Psychological Stress” https://www.sciencedirect.com/science/article/pii/S1877117318300747 (not freely available) “Chapter Eleven: Using Epigenetic Tools to Investigate Antidepressant Response” https://www.sciencedirect.com/science/article/pii/S1877117318300711 (not freely available) “Chapter Twelve: Transgenerational Epigenetics of … Continue reading A book review of “Neuroepigenetics and Mental Illness”