The fourth paper of Transgenerational epigenetic inheritance week was a 2016 German rodent study of transgenerational epigenetic effects of alcohol: “We investigated 2 generations of offspring born to alcohol-treated mothers. Here, we show that memory impairment and reduced synthesis of acetylcholine occurs in both F1 (exposed to ethanol in utero) and F2 generation (never been exposed to … Continue reading Transgenerationally inherited epigenetic effects of fetal alcohol exposure
The third paper of Transgenerational epigenetic inheritance week was a 2016 Swiss rodent study of immune system epigenetic effects: “Our study demonstrates for, we believe, the first time that prenatal immune activation can negatively affect brain and behavioral functions in multiple generations. These findings thus highlight a novel pathological aspect of this early-life adversity in shaping … Continue reading Transgenerational pathological traits induced by prenatal immune activation
The second paper of Transgenerational epigenetic inheritance week was a 2017 German/Israeli review focused on: “The inter- and transgenerational effects of stress experience prior to and during gestation..the concept of stress-induced (re-)programming in more detail by highlighting epigenetic mechanisms and particularly those affecting the development of monoaminergic transmitter systems, which constitute the brain’s reward system..we offer … Continue reading Experience-induced transgenerational programming of neuronal structure and functions
The first paper of Transgenerational epigenetic inheritance week was a 2017 Canadian/Netherlands review that’s organized as follows: “First, we address mechanisms of developmental and transgenerational programming of disease and inheritance. Second, we discuss experimental and clinical findings linking early environmental determinants to adverse aging trajectories in association with possible parental contributions and sex-specific effects. Third, we … Continue reading Transgenerational effects of early environmental insults on aging and disease
Transgenerational epigenetic inheritance is a subject whose time has come. This week I sequentially curated two 2017 reviews and two 2016 studies of the subject, and ended with a meta-analysis of human preventive treatments: Transgenerational effects of early environmental insults on aging and disease Experience-induced transgenerational programming of neuronal structure and functions Transgenerational pathological traits … Continue reading It’s transgenerational epigenetic inheritance week!
This 2015 Washington review of epigenetic transgenerational inheritance of reproductive disease defined transgenerational effects as follows: “In considering transgenerational phenomena it is important to distinguish between direct exposure effects versus germline (sperm or egg) mediated transgenerational events. When a gestating F0 generation female is exposed the F0 generation female, the F1 generation fetus and the … Continue reading A review of epigenetic transgenerational inheritance of reproductive disease
This 2015 Pennsylvania rodent study found: “Sperm miRs [microRNAs, a small non-coding RNA that has a role in gene expression] function to reduce maternal mRNA [messenger RNA, a large RNA that carries codes for protein production] stores in early zygotes, ultimately reprogramming gene expression in the offspring hypothalamus and recapitulating the offspring stress dysregulation phenotype.” … Continue reading Transgenerational epigenetic programming with stress and microRNA
I have high expectations of natural science researchers. I assume that their studies will improve over time, and develop methods and experiments that produce reliable evidence to inform us of human conditions. My confidence is often unrealistic. Scientists are people, after all, and have the same foibles as the rest of us. I anticipate that … Continue reading The Not-Invented-Here syndrome
This 2018 French/Italian/Swiss rodent study was an extension of the work done by the group of researchers who performed Prenatal stress produces offspring who as adults have cognitive, emotional, and memory deficiencies and Treating prenatal stress-related disorders with an oxytocin receptor agonist: “Reduction of maternal behavior [nursing behavior, grooming, licking, carrying pups] was predictive of … Continue reading The lifelong impact of maternal postpartum behavior
Two items before getting to the review: 94% of rodent genera are naturally uniparental; The Rattus and Mus genera used in almost all rodent research aren’t part of the 6% in which fathers also provide offspring care. This 2018 Australian review subject was paternal intergenerational and transgenerational transmission of biological and behavioral phenotypes per this … Continue reading How well do single-mother rodent studies inform us about human fathers?