This 2023 rodent study found that effects of stress during mid-late gestation were epigenetically transmitted to the first, second, and third female generations: “We investigated effects of gestational chronic variable stress (CVS) in rats using restraint and social isolation stress in the parental F0 generation. Only the F0 pregnant dams were subjected to stress. When … Continue reading Transgenerational transmission of stress
A 2021 interview with McGill University’s Moshe Szyf: “There is a rejection of transgenerational inheritance as it goes against progressive thinking because it ties us to previous generations. The theory faces rejection because it sounds deterministic. But if you understand what epigenetics is, it’s not deterministic. There is stability, and there’s also room for dynamic … Continue reading The impact of transgenerational epigenetic inheritance and early life experiences
This 2020 study followed up The transgenerational impact of Roundup exposure using the Washington State Unversity research group’s most recent methodology in DEET and permethrin cause transgenerational diseases: “The herbicide glyphosate has been shown to promote epigenetic transgenerational inheritance of pathology and disease in subsequent great-grand offspring (F3 generation). The current study was designed to … Continue reading Part 2 of The transgenerational impact of Roundup exposure
This 2020 rodent study from the labs of Dr. Michael Skinner at Washington State University examined how great-grandmothers’ insect repellent exposures produced diseases in their great-grand offspring: “Permethrin and DEET are the pesticides and insect repellent most commonly used by humans. These pesticides have been shown to promote the epigenetic transgenerational inheritance of disease in … Continue reading DEET and permethrin cause transgenerational diseases
My 600th curation is a 2020 rodent study from Dr. Michael Skinner’s labs at Washington State University: “Numerous environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of disease and phenotypic variation. Alterations in the germline epigenome are necessary to transmit transgenerational phenotypes. In previous studies, the pesticide DDT and the agricultural fungicide … Continue reading Transgenerational epigenetic inheritance of epimutations
This 2020 review by coauthors of 2019’s A transgenerational view of the rise in obesity and Epigenetic transgenerational inheritance extends to the great-great-grand offspring summarized: “The prevalence of obesity and associated diseases has reached pandemic levels. Ancestral and direct exposures to environmental toxicants and altered nutrition have been shown to increase susceptibility for obesity and … Continue reading A compelling review of epigenetic transgenerational inheritance
This 2020 Swiss/German review mainly cited weed, worm, and yeast studies: “RNA interference-related mechanisms can mediate the deposition and transgenerational inheritance of specific chromatin modifications in a truly epigenetic fashion. Epigenetics was initially defined as any heritable change in gene expression patterns without changes in the DNA sequence. Now, epigenetic phenomena are often characterized as … Continue reading An evolutionary view of transgenerational epigenetic inheritance
This December 3, 2019, French review title was “Transgenerational Inheritance of Environmentally Induced Epigenetic Alterations during Mammalian Development”: “We attempt to summarize our current knowledge about transgenerational inheritance of environmentally induced epigenetic changes. While the idea that information can be inherited between generations independently of DNA’s nucleotide sequence is not new, the outcome of recent … Continue reading An out-of-date review of epigenetic transgenerational inheritance
This 2019 Washington State University rodent study found epigenetically inherited transgenerational effects in great-grand offspring due to their great-grandmothers’ toxicant exposures during pregnancy: “Previous studies found an increased susceptibility to obesity in F3 generation rats ancestrally exposed to the pesticide DDT, and an increase in a lean phenotype in the F3 generation rats ancestrally exposed … Continue reading A transgenerational view of the rise in obesity
This 2019 rodent study by the Washington State University labs of Dr. Michael Skinner continued to F4 generation great-great-grand offspring, and demonstrated that epigenetic inheritance mechanisms are similar to imprinted genes: “Epigenetic transgenerational inheritance potentially impacts disease etiology, phenotypic variation, and evolution. An increasing number of environmental factors from nutrition to toxicants have been shown … Continue reading Epigenetic transgenerational inheritance extends to the great-great-grand offspring
My 500th curation is a 2019 Portuguese human study of Azorean islanders: “This study demonstrates a transgenerational epigenetic inheritance in humans produced by exposure to high TH [thyroid hormone] in fetal life, in the absence of maternal influences secondary to thyrotoxicosis. The inheritance is along the male line. The present work took advantage of the … Continue reading Transgenerational epigenetic inheritance of thyroid hormone sensitivity
This 2019 rodent study from the labs of Dr. Michael Skinner at Washington State University found: “The exposure of a gestating female during fetal gonadal sex determination to DDT can promote the epigenetic transgenerational inheritance of obesity and disease. Transgenerational pathologies (F3 generation) of late puberty, obesity, testis, prostate, and multiple disease were observed in … Continue reading Transgenerational diseases caused by great-grandmother DDT exposure
This 2019 Washington State University rodent study from Dr. Michael Skinner’s lab found: “A cascade of epigenetic alterations initiated in PGCs [primordial germ cells of F3 males] appears to be required to alter epigenetic programming during spermatogenesis to modify the sperm epigenome involved in transgenerational epigenetic inheritance phenomenon. Following fertilization there is a DNA methylation … Continue reading Another important transgenerational epigenetic inheritance study
This 2019 Washington rodent study from Dr. Michael Skinner’s lab found adverse effects in the grand-offspring and great-grand-offspring following their ancestor’s exposure during pregnancy to the world’s most commonly used herbicide: “Using a transient exposure of gestating F0 generation female rats found negligible impacts of glyphosate on the directly exposed F0 generation, or F1 generation … Continue reading The transgenerational impact of Roundup exposure
This 2019 Washington State University rodent study found: “Ancestral exposure to toxicant vinclozolin induces an epigenetic transgenerational increase in susceptibility to prostate pathology in F3 [male great-grandchildren] generation rats. These results are in agreement with previous studies which found a transgenerational increase in rates of prostatic: Epithelial atrophy; Cystic hyperplasia; and Prostatitis in transgenerational F3 … Continue reading Epigenetic transgenerational inheritance mechanisms that lead to prostate disease
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