A study of perinatal malnutrition where the paradigm excluded epigenetic inheritance

This 2017 New York/Swedish rodent study subject was the epigenetic effects on the F1 children of maternal low protein diet during pregnancy and lactation: “Male, but not female, offspring of LPD [low protein diet] mothers consistently displayed anxiety- and depression-like behaviors under acute stress. Our proposed pathway connecting early malnutrition, sex-independent regulatory changes in Egr1 … Continue reading A study of perinatal malnutrition where the paradigm excluded epigenetic inheritance

How one person’s paradigms regarding stress and epigenetics impedes relevant research

This 2017 review laid out the tired, old, restrictive guidelines by which current US research on the epigenetic effects of stress is funded. The reviewer rehashed paradigms circumscribed by his authoritative position in guiding funding, and called for more government funding to support and extend his reach. The reviewer won’t change his beliefs regarding individual … Continue reading How one person’s paradigms regarding stress and epigenetics impedes relevant research

The current paradigm of child abuse limits pre-childhood causal research

As an adult, what would be your primary concern if you suspected that your early life had something to do with current problems? Would you be interested in effective treatments of causes of your symptoms? Such information wasn’t available in this 2016 Miami review of the effects of child abuse. The review laid out the … Continue reading The current paradigm of child abuse limits pre-childhood causal research

A review that inadvertently showed how memory paradigms prevented relevant research

This 2016 Swiss review of enduring memories demonstrated what happens when scientists’ reputations and paychecks interfered with them recognizing new research and evidence in their area but outside their paradigm: “A framework containing the basic assumptions, ways of thinking, and methodology that are commonly accepted by members of a scientific community.” 1. Most of the … Continue reading A review that inadvertently showed how memory paradigms prevented relevant research

Transgenerational effects of early environmental insults on aging and disease

The first paper of Transgenerational¬†epigenetic inheritance week was a 2017 Canadian/Netherlands review that’s organized as follows: “First, we address mechanisms of developmental and transgenerational programming of disease and inheritance. Second, we discuss experimental and clinical findings linking early environmental determinants to adverse aging trajectories in association with possible parental contributions and sex-specific effects. Third, we … Continue reading Transgenerational effects of early environmental insults on aging and disease

Epigenetic effects of early life stress exposure

This 2017 Netherlands review subject was the lasting epigenetic effects of early-life stress: “Exposure to stress during critical periods in development can have severe long-term consequences..One of the key stress response systems mediating these long-term effects of stress is the hypothalamic-pituitary-adrenal (HPA) axis..early life stress (ELS) exposure has been reported to have numerous consequences on … Continue reading Epigenetic effects of early life stress exposure

Empathy, value, pain, control: Psychological functions of the human striatum

This 2016 US human study found: “A link between existing data on the anatomical and physiological characteristics of striatal regions and psychological functions. Because we did not limit our metaanalysis to studies that specifically targeted striatal function, our results extend previous knowledge of the involvement of the striatum in reward-related decision-making tasks, and provide a … Continue reading Empathy, value, pain, control: Psychological functions of the human striatum

About

I started this blog in February 2015 to curate recent research primarily found on PNAS.org. After reading dozens of PNAS studies where the findings weren’t warranted by the data, culminating in¬†The link between scientific value and content is broken at PNAS.org a year later, I now mainly curate studies that are immediately freely and fully … Continue reading About