This 2023 rodent study investigated relationships of MK-7 menaquinone, aluminum trichloride, and brain health:
“A variety of endogenous and exogenous agents, such as metals and environmental toxins (aluminum, mercury, etc.), can contribute to neurodegeneration, which is of multifactorial clinical occurrence.
The current study showed that Alzheimer’s Disease (AD)-like condition was induced in mice by AlCl3 treatment affecting spatial and recognition memory. Neuropathological alterations included neuroinflammation, oxidative stress, an increase in brain amyloid β levels, and loss of hippocampal neurons.
Aluminium chloride (AlCl3; 100 mg/kg for 3 weeks orally) was administered to Swiss albino mice to induce neurodegeneration and Vitamin K2 (100 mcg/kg for 3 weeks orally) was applied as treatment. This was followed by behavioral studies to determine memory changes.
Antioxidants like glutathione and SOD were low compared to the control group, while oxidative stress marker MDA was elevated. BDNF levels increased in the Vitamin K2 treated animals, suggesting its neuroprotective functions.
Vitamin K2 could partially reverse AlCl3-mediated cognitive decline. It increased hippocampal acetylcholine and BDNF levels while reducing oxidative stress, neuroinflammation, and β-amyloid deposition, protecting hippocampal neurons from AlCl3-mediated damage.“
https://link.springer.com/article/10.1007/s10787-023-01290-1 “Vitamin K2 protects against aluminium chloride-mediated neurodegeneration” (not freely available)
This study’s human equivalent Vitamin K2 dose is (100 mcg x .081) x 70 kg = 567 mcg. I’ve taken 600 mcg MK-7 every day for the past two years.
Found out last week that I’ve also been inadvertently dosing myself with aluminum every day. This is the underside of my former 3-year-old drip coffee maker with its cover removed:
I’m certain its aluminum tubing that heats reservoir water started to corrode a long time ago. Currently trying out methods of making aluminum-free coffee.
Surface Your Real Self 
Isn’t it more like 5670mcg and not 567mcg pr day for a 70kg person, or did I miss something in the calculation?, and thanks for bringing this to my attention. I do supplement with K2, but I won’t do 5670mcg pr day until there is a clinical studies on humans on long term saftey data.
It’s 567 mcg for a human. (100 mcg x .081) = 8.1 then (8.1 x 70 kg) = 567 mcg.
I uploaded another graphic that shows the mouse dose was 100 mcg. If you click the study link, you’ll see that these researchers put the wrong unit of measurement into the abstract. So much for the peer review process.
How do you make coffee?
Thanks for the clarification! As for coffee, I’ve skipped it completely, after I heard an interview with Dr. Mathew Walker, where he mentioned coffee’s negative impact on REM sleep. I stick to green tea and always use a an electric kettle with a stainless steel bottom.
Btw, what is your daily intake of sprouts. I take 65grams of fresh sprouts twice a day (a total of 130g), separated by an 8 hour window.
Good stuff! I did the same from Week 6 through Week 87. Then dialed it back to once a day per:
Week 87 of Changing to a youthful phenotype with sprouts.
As for coffee, I’ve skipped it completely after I heard an interview with Dr. Matthew Walker and the negative impact coffee has on REM sleep. I do consume green tea in the morning however. I use a quality electric kettle with a stainless steel interior.