Eat broccoli sprouts to prevent thrombosis

This 2023 cell / rodent study investigated dietary plant compounds for their functions related to blood clots after emergencies like heart attack and stroke:

“We evaluated phenotypes associated with irreversible protein engagement of twenty-three electrophilic phytochemicals. This revealed a novel antiplatelet selectivity profile of natural product sulforaphane (SFN).

Response of platelets to adenosine diphosphate and a thromboxane A2 receptor agonist was impaired without affecting thrombin and collagen-related peptide activation. SFN also substantially reduced formation of platelet thrombi on surfaces coated with collagen under arterial flow conditions.

23 electrophilics

SFN displayed important characteristics of prophylactic agents. It was able to improve clot-busting performance of recombinant tissue plasminogen activator (rtPA) in an in vivo electrolytic injury model of thrombosis without increasing blood loss.

All current antiplatelet agents are contraindicated for adjunctive therapies for thrombolysis in stroke patients, due to the high risk of symptomatic brain hemorrhage, the most feared complication of thrombolytic therapy. Our results serve as a catalyst for further investigations into preventive and therapeutic mechanisms of dietary antiplatelets, with a view to develop more effective and safer adjunctive treatments to improve clot-busting power of rtPA – currently the sole approved therapeutic for stroke recanalization that has significant limitations.”

https://chemrxiv.org/engage/chemrxiv/article-details/64a2ca49ba3e99daef721461 “Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets”


PXL_20230808_100051434.NIGHT

4 thoughts on “Eat broccoli sprouts to prevent thrombosis

  1. I wish there would be an easier way to obtain sulforophane than sprouting broccoli seeds. I’m not at home sevral days of the week, so taking care of sprouts is not really an option for me, unfortunately. Sulforophane supllements are rather expensive and quality seems to be an issue.

    • Thanks for commenting Mr. Pedersen! You’re right, supplements are too expensive.
      Yesterday I requested a review copy of a July 2023 study where the researchers ground red radish seeds to good effect with a burr grinder. After they respond, we’ll try to figure out if that could have some practical home use.
      Until then, what do you think about Microwave broccoli seeds to create sulforaphane?

  2. Thanks for your input ‘gettingwell4’ The effects from sulforophane are nothing short of mindblowing. Doctors should prescribe broccoli sprouts as first-line treatment for inflammaging. I’ve started my first week of sproutning, and those weeks were I’m unable to sprout, I will consume chopped broccoli instead to get a decent amount of sulforophane. I will look forward to the red raddish study. Thanks for bringing all of this to my attention 🙂

    • Sounds good! Whatever you can do to keep up your intake.
      I haven’t been getting good responses lately from researchers. Still have 47 outstanding requests for papers. Maybe everybody’s on vacation?

Leave a comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.