A 2025 review subject was sulforaphane and brain health. This paper was the latest in a sequence where the retired lead author self-aggrandized his career by citing previous research.
He apparently doesn’t personally do what these research findings suggest people do. The lead author is a few weeks older than I am, and has completely white hair per an interview (Week 34 comments). I’ve had dark hair growing in (last week a barber said my dark hair was 90%) since Week 8 of eating broccoli sprouts every day, which is a side effect of ameliorating system-wide inflammation and oxidative stress.
If the lead author followed up with what his research investigated, he’d have dark hair, too. Unpigmented white hair and colored hair are both results of epigenetics.
Contrast this lack of personal follow-through of research findings with Dr. Goodenowe’s protocol where he compared extremely detailed personal brain measurements at 17 months and again at 31 months. He believes enough in his research findings to personally act on them, and demonstrate to others how personal agency can enhance a person’s life.
It’s every human’s choice whether or not we take responsibility for our own one precious life. I’ve read and curated on this blog many of this paper’s references. Five years ago for example:
- How much sulforaphane is suitable for healthy people? and
- Upgrade your brain’s switchboard with broccoli sprouts.
So do more with their information than just read.
https://www.mdpi.com/2072-6643/17/8/1353 “Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders”
Surface Your Real Self 
For years, I’ve been struggling with achilles tendonitis (AT). Physical therapy and collagen supplementation for a couple of years now, has greatly reduced my AT. I’ve consumed broccoli sprouts daily for the last two weeks, and all of a sudden my AT has re-emerged. I can’t help to think that Nrf2’s collagen and elastin inhibiting feature could be the culprit. Anyhow, I’m pausing with the sprouts for some weeks now, just to se, if the pain subsides.
Never give up, Ole.
I had peroneal tendinosis of the left ankle for two years before starting to eat broccoli sprouts every day. That was back when I trusted doctors, and I tried their various treatments, which didn’t work for permanent relief.
It hasn’t gone away, but preceding problems of arthritis of my left thumb and left knee pain have eventually resolved. It’s difficult to take duration guidance from rodent studies because two weeks for a human is equivalent to half a day for rats, and even shorter for mice.
thanks for your reply. The benefits of Nrf2 activation are just too compelling. Although highly subjective, sleep quality has improved (probably due to less inflammation), exercise performance and stamina too, so not all bad. I’m upping my collagen dosage and glycine intake and hoping that it will counteract at least some of the collagen and elastin degradation.