This 2020 meta-analysis subject was DHEA: “Twenty-four qualified trials were included in this meta-analysis. Statistically significant increases in serum IGF-1 levels were found only in participants who were: Women; or Supplementing 50 mg/d; or Undergoing intervention for > 12 weeks; or Without an underlying comorbidity; or Over the age of 60 years. DHEA supplementation led … Continue reading Take responsibility for your one precious life – DHEA
This 2020 review subject was the normal progression of our immune systems: “Age-related alterations in the immune system result in high susceptibility to infections, increased risk of hospitalization and mortality. Defects in adaptive immunity underlie the markedly low vaccine efficiency in the elderly. Despite reduced cellular functions, a systemic increase in inflammatory markers, so-called inflammaging, … Continue reading Take responsibility for your one precious life – Trained innate immunity
From the main page of https://www.betaglucan.org/, a compilation for researchers: “Beta Glucan extracted from yeast cell wall, can be a potent immune response potentiator and modulator. A common test to determine a glucan’s immune response potentiation effectiveness is the measure of the degree to which a glucan increases the nitric oxide burst, a pathogen killing … Continue reading Take responsibility for your one precious life – β glucan
Where to start among 6,489 studies and reviews published during the past five years, results from a PubMed search of “dihydroxyvitamin D3.” How about: “Vitamin D plays a fundamental role in body calcium and phosphorous homeostasis, ensuring proper functioning of the skeletomuscular system. Pleiotropic activities include: Anti-inflammatory and immunomodulatory properties (predominantly downregulation of adaptive and … Continue reading Take responsibility for your one precious life – Vitamin D3
This 2020 review highlighted earlier clinical data on zinc: “Zinc is known to modulate antiviral and antibacterial immunity and regulate inflammatory response. Zinc possesses anti-inflammatory activity by inhibiting NF-κB signaling and modulation of regulatory T-cell functions. The most critical role of zinc is demonstrated for the immune system. Zinc regulates proliferation, differentiation, maturation, and functioning … Continue reading Take responsibility for your one precious life – Zinc
A few months ago I had a series of interactions with a late-twenties person who’d escaped from Manhattan. They were well-off enough to work remotely from anywhere, but they chose to move into their mother’s house. I tried to see them as an individual. I presented Wake up, young people!! arguments: “Your future lives are … Continue reading Continue sleepwalking, young people
This 2020 human study investigated effects of processing β-glucan: “Nutritional advantages of oats compared to many other grains include gluten-free nature, high content of polyunsaturated fatty acids, protein composition which complements that of pulses, and substantiated health effects of fibers, specifically oat β-glucan. Novel oat products, which are often semi-solid or liquid, generally need alterations … Continue reading An oats β-glucan clinical trial
Photos taken in Milan and Lake Como, Italy, February 22-23, 2020. The same weekend during which ten towns were closed south of the city. As I said in Train your immune system every day! my traveling companion and I were likely exposed, yet had no symptoms after two weeks. Take responsibility for your one precious … Continue reading In memory of freedom through February 2020
This 2020 review subject concerned a leading cause of blindness: “Advanced glycation end products (AGEs) are toxic compounds that have adverse effects on many tissues including the retina and lens. AGEs promote the formation of reactive oxygen species (ROS), which, in turn, boost the production of AGEs, a vicious cycle. Diabetic retinopathy (DR) is a … Continue reading Eat broccoli sprouts for your eyes
If seven weeks beforehand there was Halloween candy in grocery stores, and for the past week Christmas sales, we can review top ranked 2020 blog post categories. Here’s a ranked list of readers’ interests of categories, then of posts within each category ranked by reader views. Prioritize it to your liking. 1. Manipulation of human … Continue reading Top 2020 blog post categories
This comprehensive 2020 rodent study investigated dozens of scenarios for β-glucan in the context of anti-tumor immunity: “Neutrophils and granulopoietic progenitors are major cellular effectors of β-glucan-induced trained immunity. The anti-tumor effect of β-glucan-induced trained immunity was mediated by qualitative changes in neutrophils. A tumor-suppressive phenotype in neutrophils was associated with training of granulopoiesis mediated … Continue reading Anti-tumor effects of β-glucan
Ever heard about AGEs? Here are three papers that describe how AGEs affect humans. First is a 2020 Italian review Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System: “Neurodegenerative disease is an umbrella term for different conditions which primarily affect the neurons in the human brain. Currently, … Continue reading Get serious about advanced glycation end products (AGEs)
By request, here’s what I recommend after growing and eating broccoli sprouts every day for the past twenty weeks. 1. Develop a strategic goal. Eating broccoli sprouts can achieve several goals. Mine has been to address inflammation. 2. Use a relevant model. I used the 2018 clinical trial Effects of long-term consumption of broccoli sprouts … Continue reading Grow a broccoli sprouts Victory Garden today!
This past Saturday evening into night I walked five miles over three hours in Manchester, New Hampshire, with two individuals. Several items of interest, incidental to our enjoyable experiences: My first impression was that it could have been this time last year. People who had spent a long winter and spring indoors were happy to … Continue reading Supporting individuals
This 2019 US review subject was β-glucan: “β-1,3-Glucans (hereafter referred to as glucan) are natural molecules able to significantly improve our health. In human studies, the tested (and suggested) daily dose remains in the range of 100–500 mg for stimulation of the immune system, whereas for a decrease in cholesterol levels a daily dose of … Continue reading Train your immune system every day!