Take responsibility for your one precious life – DHEA

This 2020 meta-analysis subject was DHEA: “Twenty-four qualified trials were included in this meta-analysis. Statistically significant increases in serum IGF-1 levels were found only in participants who were: Women; or Supplementing 50 mg/d; or Undergoing intervention for > 12 weeks; or Without an underlying comorbidity; or Over the age of 60 years. DHEA supplementation led … Continue reading Take responsibility for your one precious life – DHEA

Take responsibility for your one precious life – Trained innate immunity

This 2020 review subject was the normal progression of our immune systems: “Age-related alterations in the immune system result in high susceptibility to infections, increased risk of hospitalization and mortality. Defects in adaptive immunity underlie the markedly low vaccine efficiency in the elderly. Despite reduced cellular functions, a systemic increase in inflammatory markers, so-called inflammaging, … Continue reading Take responsibility for your one precious life – Trained innate immunity

Take responsibility for your one precious life – β glucan

From the main page of https://www.betaglucan.org/, a compilation for researchers: “Beta Glucan extracted from yeast cell wall, can be a potent immune response potentiator and modulator. A common test to determine a glucan’s immune response potentiation effectiveness is the measure of the degree to which a glucan increases the nitric oxide burst, a pathogen killing … Continue reading Take responsibility for your one precious life – β glucan

Take responsibility for your one precious life – Vitamin D3

Where to start among 6,489 studies and reviews published during the past five years, results from a PubMed search of “dihydroxyvitamin D3.” How about: “Vitamin D plays a fundamental role in body calcium and phosphorous homeostasis, ensuring proper functioning of the skeletomuscular system. Pleiotropic activities include: Anti-inflammatory and immunomodulatory properties (predominantly downregulation of adaptive and … Continue reading Take responsibility for your one precious life – Vitamin D3

Take responsibility for your one precious life – Zinc

This 2020 review highlighted earlier clinical data on zinc: “Zinc is known to modulate antiviral and antibacterial immunity and regulate inflammatory response. Zinc possesses anti-inflammatory activity by inhibiting NF-κB signaling and modulation of regulatory T-cell functions. The most critical role of zinc is demonstrated for the immune system. Zinc regulates proliferation, differentiation, maturation, and functioning … Continue reading Take responsibility for your one precious life – Zinc

How to measure biological age?

As mentioned in Week 127, I had biological age measured earlier this month, and received five reports two days ago on Sunday. Part of the company’s process is to follow up their reports (intrinsic aging, immune aging, pace of aging, telomere length, weight loss) with a consulting session to review and interpret, which lasted an … Continue reading How to measure biological age?

Week 120 of Changing to a youthful phenotype with sprouts

It was time for an annual physical last Wednesday. My focus was to see whether reducing sulforaphane intake per Week 87 had the desired effect on thyroid measurements. That and other adjustments did! Readings of TSH 2.91 (0.45 – 4.50 uIU/mL), free T4 1.22 (0.82 − 1.77 ng/dL), and free T3 2.4 (2.0 – 4.4 … Continue reading Week 120 of Changing to a youthful phenotype with sprouts

Unconscious act-outs all the way down

Haven’t curated a study for a while that actually detracted from science. This 2022 human clinical trial that polluted broccoli sprout compounds research provoked me into it: “Forty-nine participants enrolled, including 26 (53%) females with median use of 20 cigarettes/day. Low and higher-dose broccoli seed and sprout extracts (BSSE) showed a mean bioavailability of 11% … Continue reading Unconscious act-outs all the way down

Vitamin D and pain

This 2022 human study investigated epigenetic clock associations: “We assessed the potential relationship of Vitamin D’s effects on pain intensity and disability through associations in epigenetic aging in individuals with and without knee osteoarthritis (KOA). We hypothesized that associations between Vitamin D levels with pain intensity and interference in persons with KOA would be significantly … Continue reading Vitamin D and pain

MET minutes

This 2022 meta-analysis investigated the relationship between cognition and exercise expressed in MET minutes (metabolic equivalent for task, a unit that estimates amount of energy used during physical activity compared to resting metabolism): “44 studies (4793 participants aged 50 years or over) were included. There was a non-linear, dose-response association between overall exercise and cognition. … Continue reading MET minutes

Year Two of Changing to a youthful phenotype with sprouts

1. I’ve eaten clinically-relevant doses of sulforaphane every day for 104 weeks now with microwaved 3-day-old broccoli, red cabbage, and mustard sprouts. That’s 8+ times longer than any sulforaphane clinical trial. I continue to: Eat Avena nuda oats for breakfast; Eat 3-day-old hulled Avena sativa oat sprouts twice a day; Eat AGE-less chicken vegetable soup … Continue reading Year Two of Changing to a youthful phenotype with sprouts

Gut microbiota knowledge through 2021

I’ll curate this 2022 review of what’s known and unknown about our trillions of gut microbiota through its topic headings: “Most microbial taxa and species of the human microbiome are still unknown. Without revealing the identity of these microbes as a first step, we cannot appreciate their role in human health and diseases. A. Understanding … Continue reading Gut microbiota knowledge through 2021

Predicting atherosclerosis

Starting this blog’s eighth year with a 2022 epigenetic clock study that assessed young people’s common blood tests fifteen and twenty years later: “GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with atherosclerotic cardiovascular disease. We used multivariable regression models to examine associations of Y15 and Y20 GAA estimates with plasma … Continue reading Predicting atherosclerosis

Immune system aging

This 2021 review by three coauthors of Take responsibility for your one precious life – Trained innate immunity cast a wide net: “Non-specific innate and antigen-specific adaptive immunological memories are vital evolutionary adaptations that confer long-lasting protection against a wide range of pathogens. However, these mechanisms of memory generation and maintenance are compromised as organisms … Continue reading Immune system aging

Human agency vs. brain dysfunction

This 2021 human study used epigenetic clock technology to assess chronic inflammation as a driver of cognitive decline through its effects on brain structure: “An epigenetic measure of C-reactive protein (DNAm CRP) was assembled for each participant. We found that higher inflammatory burden, indexed by DNAm CRP scores, associated with poor cognitive and neuroimaging brain … Continue reading Human agency vs. brain dysfunction