Predicting atherosclerosis

Starting this blog’s eighth year with a 2022 epigenetic clock study that assessed young people’s common blood tests fifteen and twenty years later:

GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with atherosclerotic cardiovascular disease. We used multivariable regression models to examine associations of Y15 and Y20 GAA estimates with plasma lipid levels measured at prior examination years (Y0, Y5, and Y10) and concurrently: triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels:

  • Each 1-SD higher cumulative TG level was associated with an average 0.73 ± 0.12 years older GAA;
  • Each 1-SD higher cumulative HDL-C level was associated with an average 0.57 ± 0.17 years younger GAA;
  • Associations between TG and GAA were stronger among female and Black participants; and
  • Associations between HDL-C and GAA were stronger among female and White participants.


We observed that elevated TG and low HDL-C levels in young adulthood are associated with accelerated midlife epigenetic aging, and epigenetic aging mediates some of the well-described associations between elevated TG levels in early life and subclinical atherosclerosis in middle age. These findings suggest that maintaining optimal lipid levels in early adulthood may help to slow epigenetic aging, which reflects delays in the onset of age-related diseases like atherosclerosis.” “Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study”

Which is better for resolving a health situation?

  • Hope for luck / providence before subclinical symptoms become clinical problems?
  • Do nothing constructive, and depend on interventions after problems occur?
  • Take responsibility for your own one precious life?



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