Search Results for: GrimAge

Epigenetic effects of plasma concentrate

gettingwell4 4-5 stars Advanced knowledge, Epigenetics, Immune system, Memory, Stress, Telomeres , , ,

“We use data from a safety study (n = 18, mean age 74) to investigate whether human umbilical cord plasma concentrate (hereinafter Plasma Concentrate) injected weekly (1 ml intramuscular) into elderly human subjects over a 10-week period affects different biomarkers, including epigenetic age measures, standard clinical biomarkers of organ dysfunction, mitochondrial DNA copy number (mtDNA-CN), and … Continue reading Epigenetic effects of plasma concentrate

Epigenetic clocks so far in 2022

gettingwell4 4-5 stars Advanced knowledge, Epigenetics, Stress , , ,

2022’s busiest researcher took time out this month to update progress on epigenetic clocks. If I curated every study he’s contributed to, it would require at least three blog posts a week. I’ll link to a few he’s posted in August 2022 that are more appreciated in the researcher community. “In my lab, we are … Continue reading Epigenetic clocks so far in 2022

The goddess of rainbows

gettingwell4 5+ stars Premium, Acetylcholine, Dopamine, Epigenetics, Hippocampus, Hypothalamus, Immune system, Limbic system, Memory, Neurochemicals, Stress, Telomeres , , , , ,

Two 2022 papers, starting with a review of irisin: “This article is an overview of irisin generation, secretion, and tissue distribution. Its targeting of tissues or organs for prevention and treatment of chronic diseases is systematically summarized, with discussion of underlying molecular mechanisms. Irisin is an exercise-induced myokine expressed as a bioactive peptide in multiple … Continue reading The goddess of rainbows

Vitamin D and pain

gettingwell4 2-3 stars Required further work, Epigenetics , , ,

This 2022 human study investigated epigenetic clock associations: “We assessed the potential relationship of Vitamin D’s effects on pain intensity and disability through associations in epigenetic aging in individuals with and without knee osteoarthritis (KOA). We hypothesized that associations between Vitamin D levels with pain intensity and interference in persons with KOA would be significantly … Continue reading Vitamin D and pain

Epigenetic components for evaluating a person’s physical fitness

gettingwell4 4-5 stars Advanced knowledge, Epigenetics ,

This 2022 human study incorporated DNA methylation measures of four physical fitness parameters into a new epigenetic clock: “Our work introduces new DNAm biomarkers for fitness parameters of gait speed (walking speed), hand grip strength, forced expiratory volume in one second (FEV1), and maximal oxygen uptake (VO2max). These DNAm biomarkers represent new tools for researchers … Continue reading Epigenetic components for evaluating a person’s physical fitness

Predicting atherosclerosis

gettingwell4 4-5 stars Advanced knowledge, Epigenetics, Immune system ,

Starting this blog’s eighth year with a 2022 epigenetic clock study that assessed young people’s common blood tests fifteen and twenty years later: “GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with atherosclerotic cardiovascular disease. We used multivariable regression models to examine associations of Y15 and Y20 GAA estimates with plasma … Continue reading Predicting atherosclerosis

If you aren’t where you want to be, change yourself

gettingwell4 2-3 stars Required further work, Epigenetics, Primal Therapy , ,

This 2021 human study evaluated associations among epigenetic clocks and socioeconomic status: “We conducted a comprehensive, comparative analysis of associations between various dimensions of socioeconomic status (SES) (education, income, wealth, occupation, neighbourhood environment, and childhood SES) and eight epigenetic clocks in two well-powered US ageing studies: The Multi-Ethnic Study of Atherosclerosis (MESA); and The Health … Continue reading If you aren’t where you want to be, change yourself

Smoke and die early, while your twin lives on

gettingwell4 4-5 stars Advanced knowledge, Epigenetics , ,

A 2021 human twin study investigated epigenetic clocks: “This study showed that accelerated epigenetic aging is associated with increased mortality, and smoking plays a role in explaining this association. Present findings suggest that DNAm GrimAge is a strong predictor of mortality independent of genetic influences among female twin pairs. An invitation to participate in the … Continue reading Smoke and die early, while your twin lives on

Clearing out the 2020 queue of interesting papers

gettingwell4 2-3 stars Required further work, Acetylcholine, Brain development, Cerebrum, Cortisol, Dopamine, Epigenetics, Glutamate, Hippocampus, Hypothalamus, Immune system, Limbic system, Lower brain, Memory, Neurochemicals, Serotonin, Stress , , , , , , , , , , , ,

I’ve partially read these 39 studies and reviews, but haven’t taken time to curate them. Early Life Intergenerational Transmission of Cortical Sulcal Patterns from Mothers to their Children (not freely available) Differences in DNA Methylation Reprogramming Underlie the Sexual Dimorphism of Behavioral Disorder Caused by Prenatal Stress in Rats Maternal Diabetes Induces Immune Dysfunction in … Continue reading Clearing out the 2020 queue of interesting papers

Part 2 of Reversal of aging and immunosenescent trends with sulforaphane

gettingwell4 4-5 stars Advanced knowledge, Epigenetics, Immune system, Memory, Stress, Testosterone , , , , ,

Reversal of aging and immunosenescent trends with sulforaphane covered only the first 13 minutes of a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends.  Commonalities with sulforaphane research were found by PubMed searches of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Continuing … Continue reading Part 2 of Reversal of aging and immunosenescent trends with sulforaphane

A hair color anecdote

gettingwell4 2-3 stars Required further work, Epigenetics, Hypothalamus, Immune system, Limbic system, Memory, Stress

Will you excuse a poorly-evidenced observation that’s a positive development I left out of Week 8 of Changing to a youthful phenotype with broccoli sprouts? I got a haircut last weekend after waiting for Governor Klan Robes Blackface to not arrest barbershop and hair salon owners for the crime of earning a living. A thirty-something … Continue reading A hair color anecdote

Do epigenetic clocks measure causes or effects?

gettingwell4 2-3 stars Required further work, Epigenetics , ,

Starting the sixth year of this blog with a 2020 article authored by the founder of the PhenoAge epigenetic clock methodology: “The Ge[r]oscience paradigm suggests that targeting the aging process could delay or prevent the risk of multiple major age-related diseases. We need clinically valid measures of the underlying biological process and/or classification criteria for … Continue reading Do epigenetic clocks measure causes or effects?

An epigenetic clock review by committee

gettingwell4 2-3 stars Required further work, Beliefs, Cerebellum, Cerebrum, Epigenetics, Hippocampus, Immune system, Limbic system, Lower brain, Memory, Stress, Telomeres , , , , ,

This 2019 worldwide review of epigenetic clocks was a semi-anonymous mishmash of opinions, facts, hypotheses, unwarranted extrapolations, and beliefs. Diversity of viewpoints among the 21 coauthors wasn’t evident. 1. Citations of coauthors’ works seemed excessive, and they apologized for omissions. However: Challenge 5 was titled “Single-cell analysis of aging changes and disease” and Table 1 … Continue reading An epigenetic clock review by committee

A strawman argument against epigenetic clocks

gettingwell4 < 0 Detracted from science, Epigenetics, Immune system, Stress, Telomeres , ,

This 2019 review of epigenetic clocks by Washington cancer researchers ignored the elephant in the room: Their epigenetic drift paradigm is generally inapplicable to humans because the vast majority of our cells don’t divide/proliferate. They repeatedly returned to an argument for randomness as a cause for aging and disease: “A time-dependent stochastic event process, like … Continue reading A strawman argument against epigenetic clocks

Statistical inferences vs. biological realities

gettingwell4 2-3 stars Required further work, Epigenetics, Immune system, Memory, Stress, Telomeres , ,

A 2019 UCLA study introduced a derivative of the epigenetic clock named GrimAge: “DNAm GrimAge, a linear combination of chronological age, sex, and DNAm-based surrogate biomarkers for seven plasma proteins and smoking pack-years, outperforms all other DNAm-based biomarkers, on a variety of health-related metrics. An age-adjusted version of DNAm GrimAge, which can be regarded as … Continue reading Statistical inferences vs. biological realities