Epigenetic effects of cruciferous vegetable compounds

This 2017 German review discussed the results of many of the studies performed over the past thirty years investigating the health-promoting effects of cruciferous vegetable compounds:

“SFN [sulforaphane] [is] the ITC [isothiocyanate] that is the most extensively studied for its chemopreventive and anti-inflammatory properties in vitro, as well as in vivo.

Due to the reversible nature of epigenetic aberrations, a modulation of epigenetically caused changes in gene expression by phytochemicals may be a promising approach in cancer prevention at the initiation step of carcinogenesis. Both SFN and DIM [diindolemethane] reversed many of the cancer-associated promotor methylations, including abnormally-methylated genes that are dysregulated during cancer progression..modulate the abnormal expression of miRNAs in different types of cancer.”

http://www.mdpi.com/1422-0067/18/9/1890/htm “Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways”

A 2017 Polish human cell study that wasn’t cited above due to its recent publication found:

“We show for the first time that SFN is an epigenetic modulator in breast cancer cells that results in cell cycle arrest and senescence.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596436/pdf/thnov07p3461.pdf “Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells”

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2 thoughts on “Epigenetic effects of cruciferous vegetable compounds

  1. Thanks for posting this, Paul. The study shows clearly that epigenetic changes are not just caused by stress or early life trauma. Indeed, many carcinogens cause changes in the epigenome which in turn increase the risk for cancer. And now we see that foods can have an opposite effect on the epigenome. On that note, I will be having cole slaw for dinner tonight! 😀

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