Biological age and zinc

This 2022 human study investigated zinc’s influence in modulating DNA methylation patterns:

“The purpose of this study was to identify epigenetic variables related to serum Zn (ZnS) levels and Zn daily ingestion (ZnDI) in a case-control cohort. Individuals were selected and classified according to their body mass index into two groups: control group of 11 women without obesity, and study group composed of 10 women with obesity. Inclusion criteria were women aged 18–50 years with stable body weight for at least 6 months.

Novel Zinc-Related Differentially Methylated Regions in Leukocyt

A negative correlation of ZnS with epigenetic age acceleration residual suggested that the higher the ZnS levels, the lower the aging rate:

serum zinc

Our results regarding Zn homeostasis in women with obesity suggested regulation by other mechanisms besides ingestion:

  • Zn-associated differentially methylated regions may exert downstream effects on inflammation, macronutrient metabolism, and DNA/cellular process repair.
  • Hypomethylation of the PM20D1 gene could interconnect DNA methylation and nutritional status.”

https://www.frontiersin.org/articles/10.3389/fnut.2022.785281/full “Novel Zinc-Related Differentially Methylated Regions in Leukocytes of Women With and Without Obesity”


This study emphasized that nutrients aren’t the whole story on health. We also have to be in metabolic zones where our diet and nutrient choices can achieve desired effects.

Subjects’ selection criteria (BMI) was more than double the control group’s. Sometimes people’s lives show others what not to do with their own.

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