1. I’ve continued daily practices from Year Five to experience another year without being sick (if I don’t count getting MSG poisoning from Chinese food.) I consequently scheduled a doctor visit next week to get a sumatriptan prescription refilled.
2. Two modifications to what’s mentioned in 2026 diet and supplement changes:
– In that post’s comments, Ole Bisgaard Pedersen asked if I took NAD+ supplements such as NAM, NMN or NR – forms of vitamin B3 that are precursors to NAD+. I didn’t note that last year I started taking Now brand Flush-free niacin 500 mg mid-morning.
Nicotinamide riboside has the most human evidence, including a Tru Niagen clinical trial that showed improvements in peripheral artery disease. It’s too expensive for long-term use, though.
Even if I could afford it, there isn’t a magic bullet for fixing vascular system dysfunction. PAD is just one symptom of a cardiovascular system that needs to be overhauled then maintained at a healthy level. There is no clinical trial that has a logical therapeutic end point to stop treatments where a person could say, “I’ve done enough for my vascular system, my physical and cognitive functions won’t backslide.”
– 2-3 years ago, I changed from microwaving broccoli sprouts in a plastic bag to microwaving them in a small bowl with a small plate covering it to keep them from popcorning out of the bowl. I use a 1000W microwave oven on 80% power for ten seconds.
3. The two vitamin C macaque studies I’ve recently curated both ran for a human equivalent of ten years. I was encouraged that both found Nrf2 activation to be part of their causal beneficial evidence, since vitamin C wasn’t on my radar as a Nrf2 activator.
I expect that in four years I’ll write a Year Ten post on eating microwaved broccoli sprouts. I haven’t seen human evidence for broccoli extracts that bypass small intestine absorption and metabolism per Glucosinolate and isothiocyanate human interventions, or enteric capsules, or nanoformulations as suitable substitutes. Maybe studies on broccoli sprout powder or a Nrf2 activator that tops sulforaphane will be published before then, who knows.

I congratulate you on taking Niacin as Nicotinic Acid but I would steer away from the flush free or time released. Almost all examples of liver damage from Niacin are from flush free or time released.
Personally I take 1 gram of Nicotinic Acid, Rugby brand, immediate release. That is a lot of Niacin, probably too much, but I have REM Sleep Behavior Disorder and am working hard to help my mitochondria so I can ward off Parkinson’s.
I also take 15mg L-Methylfolate a day to compensate for niacin’s consumption of methyl groups.
Last note: Good call going with NA instead of NR in my high school educated opinion. I believe the only reason there is more research on NR than there is on NA is because they had a patent on NR and could monetize it. That is what they always do: Discover something that works, then try and make something like the thing that works that they can patent.
Love your blog.