I partially read more than a dozen studies this week of overdosed rodents producing p < .05 significant results. Net effect was to thwart the purpose of rodent studies – to help humans.
The latest came from search term “SIRT1” “DHEA” 2021 after I read a 2021 study Dehydroepiandrosterone protects against acetaminophen-induced liver damage in rats by upregulation of Bcl-2 and activation of sirt signalling that found:
“The study examined protective effect of exogenous administration of dehydroepiandrosterone (DHEA) against acetaminophen (APAP) -induced liver damage in rats, and tested underlying mechanisms. DHEA prevents APAP-induced liver damage by concomitant upregulation of Bcl-2 and SIRT1-dependent effect.”
The daily DHEA dose was 50 mg/kg, which is a (.162 x 50 mg) x 70 kg = 567 mg human equivalent. Eleven times the most frequent human dose of Take responsibility for your one precious life – DHEA. Anyone who took this study’s DHEA amount would hurt themself.
The one-time acetaminophen dose was 800 mg/kg which is a (.162 x 800 mg) x 70 kg = 9 grams human equivalent. Someone who took 18 pills of the most frequent 500 mg acetaminophen dose would be attempting suicide.
How does this help humans?