DNA methylation and childhood adversity

This 2017 Georgia human review covered: “Recent studies, primarily focused on the findings from human studies, to indicate the role of DNA methylation in the associations between childhood adversity and cardiometabolic disease in adulthood. In particular, we focused on DNA methylation modifications in genes regulating the hypothalamus-pituitary-adrenal axis as well as the immune system.” Recommendations … Continue reading DNA methylation and childhood adversity

The pain societies instill into children

The human subjects of this 2017 Swiss study had previously been intentionally traumatized by Swiss society: “Swiss former indentured child laborers (Verdingkinder) were removed as children from their families by the authorities due to different reasons (poverty, being born out of wedlock) and were placed to live and work on farms. This was a practice … Continue reading The pain societies instill into children

How to cure the ultimate causes of migraines?

Most of the spam I get on this blog comes in as ersatz comments on The hypothalamus couples with the brainstem to cause migraines. I don’t know what it is about the post that attracts internet bots. The unwanted attention is too bad because the post represents a good personal illustration of “changes in the … Continue reading How to cure the ultimate causes of migraines?

What is a father’s role in epigenetic inheritance?

The agenda of this 2017 Danish review was to establish a paternal role in intergenerational and transgenerational epigenetic inheritance of metabolic diseases: “There are four windows of susceptibility which have major importance for epigenetic inheritance of acquired paternal epigenetic changes: paternal primordial germ cell (PGC) development, prospermatogonia stages, spermatogenesis, and during preimplantation.” The review was … Continue reading What is a father’s role in epigenetic inheritance?

Does a societal mandate cause DNA methylation?

This 2017 worldwide meta-analysis of humans of recent European ancestry found: “Here we provide evidence on the associations between epigenetic modifications-in our case, CpG methylation and educational attainment (EA), a biologically distal environmental factor that is arguably among the most important life-shaping experiences for individuals. Specifically, we report the results of an epigenome-wide association study [EWAS] … Continue reading Does a societal mandate cause DNA methylation?

Do preventive interventions for children of mentally ill parents work?

The fifth and final paper of Transgenerational epigenetic inheritance week was a 2017 German/Italian meta-analysis of psychiatric treatments involving human children: “The transgenerational transmission of mental disorders is one of the most significant causes of psychiatric morbidity. Several risk factors for children of parents with mental illness (COPMI) have been identified in numerous studies and meta-analyses. … Continue reading Do preventive interventions for children of mentally ill parents work?

Transgenerational effects of early environmental insults on aging and disease

The first paper of Transgenerational epigenetic inheritance week was a 2017 Canadian/Netherlands review that’s organized as follows: “First, we address mechanisms of developmental and transgenerational programming of disease and inheritance. Second, we discuss experimental and clinical findings linking early environmental determinants to adverse aging trajectories in association with possible parental contributions and sex-specific effects. Third, we … Continue reading Transgenerational effects of early environmental insults on aging and disease

It’s transgenerational epigenetic inheritance week!

Transgenerational epigenetic inheritance is a subject whose time has come. This week I sequentially curated two 2017 reviews and two 2016 studies of the subject, and ended with a meta-analysis of human preventive treatments: Transgenerational effects of early environmental insults on aging and disease Experience-induced transgenerational programming of neuronal structure and functions Transgenerational pathological traits … Continue reading It’s transgenerational epigenetic inheritance week!

Does living near a forest keep your amygdala healthier?

A thought-provoking post from A Paper a Day Keeps the Scientist Okay entitled “Living Near a Forest Keeps Your Amygdala Healthier” referenced a 2017 German human study which found: “..a relationship between place of residence and brain health: those city dwellers living close to a forest were more likely to show indications of a physiologically … Continue reading Does living near a forest keep your amygdala healthier?

Do we need to study the brain to understand the mind?

A coauthor of the studies referenced in: Advance science by including emotion in research; and Empathy, value, pain, control: Psychological functions of the human striatum offered an opinion piece in A Paper a Day Keeps the Scientist Okay entitled “Do We Need To Study The Brain To Understand The Mind?”: “The emerging consensus appears to … Continue reading Do we need to study the brain to understand the mind?