A 2021 rodent study and a blog post with 51 references investigated fat cells: “Sulforaphane (SFN) is a potent indirect antioxidant and a promising agent for controlling metabolic disorder disease. We evaluated efficacy of SFN against high fat diet (HFD)-induced-obesity mice, and investigated potential mechanisms. SFN: Suppressed HFD-induced body weight gain; Reduced fat cell [adipocyte] … Continue reading Brown your white fat cells with broccoli sprouts
A 2021 human study investigated sulforaphane treatments of autistic 3-to-12-year-olds: “Sulforaphane (SF) led to non-statistically significant changes in the total and all subscale scores of the primary outcome measure. Several effects of SF on biomarkers correlated to clinical improvements. SF was very well tolerated and safe and effective based on our secondary clinical measures. Clinical … Continue reading Does sulforaphane treat autism?
This 2020 cell study investigated antibiotic effects of broccoli sprout compounds: “In this work, we asked whether isothiocyanates (ITCs) could act synergistically with each other to increase antibacterial effect. A set of aliphatic ITCs, such as iberin, iberverin, alyssin, erucin, sulforaphen, erysolin, and cheirolin was tested in combination with sulforaphane against E. coli. All tested … Continue reading Eat broccoli sprouts instead of antibiotics
This 2021 human study investigated development and persistence of allergies: “Allergic rhinitis (AR) is a common IgE-mediated disorder involving troublesome symptoms of nasal congestion, nasal itch, sneezing, and associated eye symptoms. Like many chronic health conditions, AR stems from complex gene–environment interactions. 130 subjects with AR were recruited. Control population included 154 healthy children who … Continue reading Giving children allergies with pets
1. Per Improving healthy compounds of broccoli sprouts and Broccoli sprouts’ immune effects, this week I added mustard sprouts and red cabbage sprouts to my twice-daily routine of eating 3-day-old microwaved broccoli sprouts. At first, I started mustard and red cabbage seeds with the same 10.7 gram weight (one tablespoon) of seeds. They grew well … Continue reading Week 56 of Changing to a youthful phenotype with sprouts
This 2021 rodent study investigated mechanisms of sulforaphane’s persistent cardiac protection: “Sulforaphane (SFN) reduced Ang II‐induced CpG hypermethylation and promoted Ac‐H3 [histone H3 acetylation] accumulation in the Nrf2 promoter region, accompanied by inhibition of global DNMT [DNA methyltransferase] and HDAC [histone deacetylase] activity, and a decreased protein expression of key DNMT and HDAC enzymes. Overall, … Continue reading Eat broccoli sprouts for your heart
1. My subjective experiences these past 52 weeks are that noticeable changes keep happening due to combinations of: Eating clinically-relevant, twice-daily doses of microwaved 3-day-old broccoli sprouts, and taking nothing else an hour before or an hour after; Eating 3-day-old oat sprouts twice a day; Exercising every day; Taking yeast cell wall β-glucan and other … Continue reading Year One of Changing to a youthful phenotype with broccoli sprouts
This 2021 review subject was a measurable aspect of our early lives: “The first 1000 days from conception are a sensitive period for human development programming. During this period, environmental exposures may result in long-lasting epigenetic imprints that contribute to future developmental trajectories. The present review reports on effects of adverse and protective environmental conditions … Continue reading Our first 1000 days
1. Effects of broccoli sprouts that seemed personally astounding at Week 10 became a part of day-to-day life. What will happen next? Day 350 of eating a clinically relevant amount of broccoli sprouts every day seems like a large number. Yet in comparison, for 6,000+ days I’ve taken a clinically relevant dose of 1/3, 1/6 … Continue reading Week 50 of Changing to a youthful phenotype with broccoli sprouts
One anecdote from “vacationing” in the Dallas area last week: I waited until temperatures were above 15° F to forage for food. The closest grocery store had the same situation as my hotel: no electricity all morning. It somehow had electricity for cash registers, but not for overhead lighting. People walked around using their phone’s … Continue reading Hooray for the People of Texas!
Two 2021 reviews presented aspects of human immune systems: “The adaptive immune system’s challenge is to protect the host through generation and differentiation of pathogen‐specific short‐lived effector T cells, while in parallel developing long‐lived memory cells to control future encounters with the same pathogen. The system highly relies on self‐renewal of naïve and memory T … Continue reading Adaptive and innate immunity
Continuing Part 1 with three DIM studies, the first of which was a 2020 chemical analysis investigating: “Anti-estrogenic, anti-androgenic, and aryl hydrocarbon receptor (AhR) agonistic activities of indole-3-carbinol (I3C) acid condensation products. I3C is a breakdown product [isothiocyanate] of glucobrassicin. Most biological activities attributed to I3C are believed to result from its acid condensation products, … Continue reading Part 2 of Eat broccoli sprouts for DIM
I’ve partially read these 39 studies and reviews, but haven’t taken time to curate them. Early Life Intergenerational Transmission of Cortical Sulcal Patterns from Mothers to their Children (not freely available) Differences in DNA Methylation Reprogramming Underlie the Sexual Dimorphism of Behavioral Disorder Caused by Prenatal Stress in Rats Maternal Diabetes Induces Immune Dysfunction in … Continue reading Clearing out the 2020 queue of interesting papers
1. Thank you to readers of this blog who find the 650+ curations and other posts worth their time. I reread blog posts after you read them, and sometimes improve them for our mutual benefit. One such post this week was Broccoli sprout compounds include sinapic acid derivatives. Although it was already fairly detailed, it … Continue reading Week 34 of Changing to a youthful phenotype with broccoli sprouts
This 2020 paper reviewed hormetic effects of a broccoli sprout compound: “Sulforaphane (SFN) induces a broad spectrum of chemoprotective effects across multiple organs that are of importance to public health and clinical medicine. This chemoprotection is dominated by hormetic dose responses that are mediated by the Nrf2/ARE pathway and its complex regulatory interactions with other … Continue reading Sulforaphane in the Goldilocks zone