Search Results for: experience

The arrogance of a paradigm exceeding its evidence

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This 2018 commentary from the American College of Emergency Physicians by 7 physicians discussed the harm that will result from imposing a mandatory paradigm of sepsis treatment. I’ll quote sections that mention evidence: “These metrics [for pneumonia treatment] had little evidentiary basis but led to an institutional-fostered culture of overdiagnosis and overtreatment. Have we learned … Continue reading The arrogance of a paradigm exceeding its evidence

The imperative of human transgenerational studies

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The coauthor of: A self-referencing study of transgenerational epigenetic inheritance; and A review of epigenetic transgenerational inheritance of reproductive disease pointed out the opportunity for the researchers of A seasonal epigenetic effect of conception on BMI to have their work make a difference in their field: “The ability of environmental epigenetics to promote an adaptive … Continue reading The imperative of human transgenerational studies

Epigenetic factors affecting female rat sexual behavior

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This 2018 Baltimore/Montreal rodent study found: “If sexually naïve females have their formative sexually rewarding experiences paired with the same male, they will recognize that male and display mate-guarding behavior towards him in the presence of a female competitor. Female rats that display mate-guarding behavior also show enhanced activation of oxytocin and vasopressin neurons in … Continue reading Epigenetic factors affecting female rat sexual behavior

The role of recall neurons in traumatic memories

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This 2018 Swiss rodent study found: “Our data show that: A subset of memory recall–induced neurons in the DG [dentate gyrus] becomes reactivated after memory attenuation, The degree of fear reduction positively correlates with this reactivation, and The continued activity of memory recall–induced neurons is critical for remote fear memory attenuation. Although other brain areas … Continue reading The role of recall neurons in traumatic memories

Prenatal programming of human HPA axis development

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This 2017 UC Irvine human review subject provided details of how fetal hypothalamic-pituitary-adrenal components and systems develop, and how they are epigenetically changed by the mother’s environment: “The developmental origins of disease or fetal programming model predicts that intrauterine exposures have life-long consequences for physical and psychological health. Prenatal programming of the fetal hypothalamic-pituitary-adrenal (HPA) … Continue reading Prenatal programming of human HPA axis development

Epigenetic effects of breast cancer treatments

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This 2018 UC San Diego review subject was the interplay between breast cancer treatments and their effects on aging: “Although current breast cancer treatments are largely successful in producing cancer remission and extending lifespan, there is concern that these treatments may have long lasting detrimental effects on cancer survivors, in part, through their impact on … Continue reading Epigenetic effects of breast cancer treatments

Group statistics don’t necessarily describe an individual

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I’m curating this 2018 UC Berkeley/Drexel/Netherlands analysis of human studies via its press coverage. The authors: “Collaborated to analyze data on hundreds of adults – some mentally or physically sound, others suffering from various conditions such as depression, anxiety, or post-traumatic stress disorder. Participants had completed surveys about their mental health and had their heart … Continue reading Group statistics don’t necessarily describe an individual

A seasonal epigenetic effect of conception on BMI

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This 2018 Swiss human/rodent study found: “The presence of brown adipose tissue (BAT) and the season of conception are linked to BMI in humans. In mice, we demonstrate that cold exposure (CE) of males, but not females, before mating results in improved systemic metabolism and protection from diet-induced obesity of the male offspring. Adipose tissue … Continue reading A seasonal epigenetic effect of conception on BMI

A disturbance in the paradigm of child abuse

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The principal way science advances is through the principle Einstein expressed as: “No amount of experimentation can ever prove me right; a single experiment can prove me wrong.” Members of the scientific community and of the public should be satisfied that the scientific process is working well when hypotheses are discarded due to nonconfirming evidence. … Continue reading A disturbance in the paradigm of child abuse

Ideaesthesia!

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This 2018 UK review subject was colored-hearing experiences from music: “Music-colour synaesthesia has a broad scope encompassing not only tone-colour synaesthesia elicited on hearing individual tones, but a complex and idiosyncratic mixture of phenomenological experiences often mediated by timbre, tempo, emotion and differing musical style. The possession of synaesthesia or absolute pitch was shown to … Continue reading Ideaesthesia!