The goddess of rainbows

Two 2022 papers, starting with a review of irisin: “This article is an overview of irisin generation, secretion, and tissue distribution. Its targeting of tissues or organs for prevention and treatment of chronic diseases is systematically summarized, with discussion of underlying molecular mechanisms. Irisin is an exercise-induced myokine expressed as a bioactive peptide in multiple … Continue reading The goddess of rainbows

Variable aging measurements

Two papers on aging measurements, starting with a 2022 human study: “We collected longitudinally across the adult age range a comprehensive list of phenotypes within four domains (body composition, energetics, homeostatic mechanisms and neurodegeneration / neuroplasticity) and functional outcomes. We integrated individual deviations from population trajectories into a global longitudinal phenotypic metric of aging. We … Continue reading Variable aging measurements

Non-CpG methylation

Three 2022 papers on methylation epigenetic modifiers, starting with a human study focused on mitochondrial DNA non-CpG methylation involving nucleobases other than guanine (arginine, cytosine, or thymine): “We collected brain tissue in the nucleus accumbens and prefrontal cortex from deceased individuals without (n = 39) and with (n = 14) drug use, and used whole-genome bisulfite sequencing to cover … Continue reading Non-CpG methylation

Blanching broccoli sprouts

Three 2022 papers of interest cited Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. Let’s start with a fairly straightforward analysis of blanching broccoli sprouts to produce sulforaphane: “We investigated the effect of blanching conditions to determine the optimal treatment that maximizes sulforaphane (SFN) content … Continue reading Blanching broccoli sprouts

Supplement evidence and counter-evidence

Three 2022 papers, starting with a rabbit study of dietary supplements: “Adding native type II collagen (NC) to the combination of chondroitin sulfate (CS), glucosamine hydrochloride (GlHCl), and hyaluronic acid (HA) showed improvements on osteoarthritis progression. Disease progression was monitored at different time points using magnetic resonance imaging biomarkers, measurement of hyaluronic acid in synovial … Continue reading Supplement evidence and counter-evidence

Green light for BBQ?

Two 2022 papers from a clinical trial investigating dietary AGEs’ effects in middle-age people: “A 4-week diet low or high in AGEs has no effect on insulin sensitivity, secretion, or clearance; vascular function; or overall inflammation in abdominally obese but healthy individuals. These findings require validation in large prospective cohort studies and in populations with … Continue reading Green light for BBQ?

The soluble receptor for AGEs

Two 2022 human studies on sRAGE, starting with one of hypoxia-related diseases: “The receptor for advanced glycation end products is found on endothelial and inflammatory cell surfaces. It binds to circulating advanced glycation end products, activating a proinflammatory protein cascade that contributes to systemic oxidative stress and inflammation. sRAGE is the soluble isoform of RAGE … Continue reading The soluble receptor for AGEs

Gut microbiota therapy

This June 2022 review cited twenty 2022 papers for relationships between Parkinson’s disease and gut microbiota: “Clinical diagnosis of PD is based on typical motor symptoms, and novel diagnostic biomarkers have been developed such as imaging markers, and α-synuclein fluid and tissue markers. Multimorbidity of non-motor disorders heighten the risk of adverse outcomes for patients … Continue reading Gut microbiota therapy

Taurine week #7: Brain

Finishing a week’s worth of 2022 taurine research with two reviews of taurine’s brain effects: “We provide a overview of brain taurine homeostasis, and review mechanisms by which taurine can afford neuroprotection in individuals with obesity and diabetes. Alterations to taurine homeostasis can impact a number of biological processes such as osmolarity control, calcium homeostasis, … Continue reading Taurine week #7: Brain

Taurine week #6: Stress

Two 2022 rodent studies of taurine’s associations with long-term stress, starting with a chronic restraint stress model: “We show that chronic restraint stress can lead to hyperalgesia accompanied by changes in gut microbiota that have significant gender differences. Corresponding changes of bacteria can further induce hyperalgesia and affect different serum metabolism in mice of the … Continue reading Taurine week #6: Stress

Taurine week #1: Biomarkers

It’s been a while since I curated taurine research. Read at least a week’s worth of 2022 papers last weekend. Let’s start with two studies that didn’t supplement with taurine, but found it was a biomarker. The first was a rodent study that treated a high fat diet with blood pressure medicine: “Non-alcoholic fatty liver … Continue reading Taurine week #1: Biomarkers

Betaine and diabetes

Three papers on betaine’s effects, starting with a 2022 review: “Rodent studies provide evidence that betaine effectively limits many diabetes-related disturbances. Betaine therapy improves glucose tolerance and insulin action, which is strongly associated with changes in insulin-sensitive tissues, such as skeletal muscle, adipose tissue, and liver. Betaine supplementation positively affects multiple genes, which expression is … Continue reading Betaine and diabetes

Food combination effects

Two 2022 studies, starting with “Increasing bound antioxidant compounds through their reaction with soluble phenolic compounds”: “Wheat, oat, rye, and rice bran samples were reacted with different concentrations of beverages (green tea infusion, black tea infusion, espresso, and red wine) rich in various soluble phenolic compounds. Green tea infusion was found to be the most … Continue reading Food combination effects

Unconscious act-outs all the way down

Haven’t curated a study for a while that actually detracted from science. This 2022 human clinical trial that polluted broccoli sprout compounds research provoked me into it: “Forty-nine participants enrolled, including 26 (53%) females with median use of 20 cigarettes/day. Low and higher-dose broccoli seed and sprout extracts (BSSE) showed a mean bioavailability of 11% … Continue reading Unconscious act-outs all the way down

Exercise substitutes?

Two papers, starting with a 2022 abstract of an ongoing in vitro study with rodent cells: “Exercise mimetics may target and activate the same mechanisms that are upregulated with exercise administration alone. This is particularly useful under conditions where contractile activity is compromised due to muscle disuse, disease, or aging. Sulforaphane and Urolithin A represent … Continue reading Exercise substitutes?