As mentioned in Week 127, I had biological age measured earlier this month, and received five reports two days ago on Sunday. Part of the company’s process is to follow up their reports (intrinsic aging, immune aging, pace of aging, telomere length, weight loss) with a consulting session to review and interpret, which lasted an … Continue reading How to measure biological age?
1. My third gut microbiome test results came in this week. I submitted a sample earlier this month to follow methods in the second paper of Improving dietary fiber research in a continuing effort to treat my gut microbiota well. But that study’s vendor was unable to ship an EU-approved product from The Netherlands to … Continue reading Week 127 of Changing to a youthful phenotype with sprouts
This 2022 rodent cell study used the natural form of sulforaphane to replicate experiments performed with mixtures of its natural and unnatural forms: “Natural sulforaphane (SFN) exists as a single enantiomer with a RS absolute configuration. Most studies focusing on its biological activities, in particular its anti-inflammatory and antioxidant activities, have been conducted using its … Continue reading Natural sulforaphane effects
A 2022 human study investigated three measurements of the CBC with Differential/Platelet test: “This study explored the relationship between the systemic immune-inflammation index (SII) and stroke prognosis. SII was defined as neutrophils × platelets/lymphocytes. Neutrophils and lymphocytes are involved in the inflammatory and immune response, whereas platelets have a primary role in the thrombo-inflammation of … Continue reading Another use of a routine blood test
I try to not curate research that wastes resources. Couldn’t help but present this 2022 rodent study: “We aimed to evaluate if sulforaphane (SFN) long-term treatment was able to prevent age-associated cognitive decline in adult (15-month-old) and old (21-month-old) female and male rats. Our results showed that SFN restored redox homeostasis in brain cortex and … Continue reading Don’t bother eating broccoli sprouts if you’re old?
A 2022 review of Nrf2 signaling hilariously avoided mentioning sulforaphane, although of ~4,000 sulforaphane published articles, two were cited. I’ll curate it anyway to highlight referenced brain effects. “A good stability of NRF2 activity is crucial to maintain redox balance and therefore brain homeostasis. In this review, we have gathered recent data about the contribution … Continue reading Broccoli sprouts and your brain
Two papers on trained immunity, starting with a 2022 review: “Live attenuated vaccines such as the Bacillus Calmette–Guérin, measles-containing vaccines, and the oral polio vaccine have been shown to reduce overall mortality beyond their effects attributable to the targeted diseases. After an encounter with a primary stimulus, epigenetic and metabolic reprogramming of bone marrow progenitor … Continue reading Trained immunity epigenetics
Two papers on aging measurements, starting with a 2022 human study: “We collected longitudinally across the adult age range a comprehensive list of phenotypes within four domains (body composition, energetics, homeostatic mechanisms and neurodegeneration / neuroplasticity) and functional outcomes. We integrated individual deviations from population trajectories into a global longitudinal phenotypic metric of aging. We … Continue reading Variable aging measurements
Three 2022 papers on methylation epigenetic modifiers, starting with a human study focused on mitochondrial DNA non-CpG methylation involving nucleobases other than guanine (arginine, cytosine, or thymine): “We collected brain tissue in the nucleus accumbens and prefrontal cortex from deceased individuals without (n = 39) and with (n = 14) drug use, and used whole-genome bisulfite sequencing to cover … Continue reading Non-CpG methylation
Three 2022 papers of interest cited Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. Let’s start with a fairly straightforward analysis of blanching broccoli sprouts to produce sulforaphane: “We investigated the effect of blanching conditions to determine the optimal treatment that maximizes sulforaphane (SFN) content … Continue reading Blanching broccoli sprouts
This June 2022 review cited twenty 2022 papers for relationships between Parkinson’s disease and gut microbiota: “Clinical diagnosis of PD is based on typical motor symptoms, and novel diagnostic biomarkers have been developed such as imaging markers, and α-synuclein fluid and tissue markers. Multimorbidity of non-motor disorders heighten the risk of adverse outcomes for patients … Continue reading Gut microbiota therapy
Two 2022 rodent studies of taurine’s associations with long-term stress, starting with a chronic restraint stress model: “We show that chronic restraint stress can lead to hyperalgesia accompanied by changes in gut microbiota that have significant gender differences. Corresponding changes of bacteria can further induce hyperalgesia and affect different serum metabolism in mice of the … Continue reading Taurine week #6: Stress
Two 2022 papers investigated taurine and skeletal muscles, starting with a rodent study of endurance exercise: “This study examined effects of taurine on dynamics of blood glucose concentration (BGC) during endurance exercise in rats. Blood was collected every 10 min from the jugular vein via cannulation. Exercise period was divided by every 40 min into … Continue reading Taurine week #4: Muscles
Three 2022 papers investigated taurine’s effects on organs, starting with a rodent study of sepsis: “Sepsis usually causes multiple organ dysfunctions and high mortality. Pathogenesis of sepsis is thought to be driven by hyperactive inflammation following pathogen invasion. If the immune system fails to eradicate pathogens, immune homeostasis is disturbed, leading to an overwhelming inflammation … Continue reading Taurine week #3: Organs
This 2022 article commented on a human / rodent study of gut dysbiosis: “Crohn’s disease (CD) is a chronic disease that causes inflammation in the gastrointestinal track. Together with ulcerative colitis, another major type of inflammatory bowel disease (IBD), these intestinal disorders affect millions of people in the U.S. and worldwide. Excessive T helper 1 … Continue reading Fueling a gut fire