This 2021 review followed up Epigenetic effects of cow’s milk and many papers since then: “Epidemiological studies associate intake of cow milk with an increased risk of diseases, which are associated with overactivated mechanistic target of rapamycin complex 1 (mTORC1) signaling. Milk’s physiological function to maintain high mTORC1 signaling at the beginning of mammalian life … Continue reading Cow milk causes disease
This 2020 stem cell review argued against rodent models of human neurodegenerative diseases: “Neuronal loss is not caused solely by intrinsic degenerative processes but rather via impaired interactions with surrounding glia and other brain cells. Dysfunctional astrocytes do not provide sufficient nutrients and antioxidants to neurons, while dysfunctional microglia cannot efficiently clear pathogens and cell … Continue reading Are rodent models of human neurodegenerative diseases realistic?
This 2021 rodent study investigated effects on offspring of maternal high-fat diet (HFD) during gestation and lactation, and offspring HFD during young adulthood: “We found that gestation was the most sensitive period to induce obesity in late life, and there was no difference between sexes in chance of obesity. Furthermore, we found that lactation and … Continue reading Happy Mothers Day
This 2021 review subject was effects of short-chain fatty acids produced by gut microbiota: “SCFAs are the main players in the interplay between diet, microbiota, and health. SCFAs contribute to intestinal homeostasis and regulation of energy metabolism. SCFAs regulate the blood–brain barrier and neuroimmunoendocrine functions. During gestation, SCFAs can cause epigenetic imprinting and protect against … Continue reading Benefits of eating fermentable fiber
This 2020 rodent study investigated yeast cell wall β-glucan effects on bacterial infections: “β-glucan is a potent inducer of epigenetic and functional reprogramming of innate immune cells, a process called trained immunity, resulting in an enhanced host response against secondary infections. We investigate whether β-glucan exposure confers protection against pulmonary Mycobacterium tuberculosis (Mtb) infection. β-glucan … Continue reading Choosing your future with β-glucan
This 2021 review subject was effects of the 100-year-old tuberculosis vaccine: “Bacillus Calmette-Guerin (BCG) vaccine is one of the most widely used vaccines. It protects against many non-mycobacterial infections secondary to its nonspecific immune effects. The mechanism for these effects includes modification of innate and adaptive immunity. BCG vaccine is known to not only boost … Continue reading Long-lasting benefits of a common vaccine
This 2021 review subject was a measurable aspect of our early lives: “The first 1000 days from conception are a sensitive period for human development programming. During this period, environmental exposures may result in long-lasting epigenetic imprints that contribute to future developmental trajectories. The present review reports on effects of adverse and protective environmental conditions … Continue reading Our first 1000 days
Two 2021 reviews presented aspects of human immune systems: “The adaptive immune system’s challenge is to protect the host through generation and differentiation of pathogen‐specific short‐lived effector T cells, while in parallel developing long‐lived memory cells to control future encounters with the same pathogen. The system highly relies on self‐renewal of naïve and memory T … Continue reading Adaptive and innate immunity
This 2021 study investigated gut microbiota differences between 100 AD patients and 71 age- and gender-matched controls: “Structural changes in fecal microbiota were evident in Chinese AD patients, with decreased alpha-diversity indices and altered beta-diversity ones, evidence of structurally dysbiotic AD microbiota. Interestingly, traditionally beneficial bacteria, such as Bifidobacterium and Akkermansia, increase in these AD … Continue reading Go with the Alzheimer’s Disease evidence
To follow up topics of Part 1‘s interview: 1. “We each have a unique microbial signature in the gut. Metabolites that you produce might not be the same ones that I produce. This makes clinical studies very difficult because you don’t have a level playing field.” This description of inter-individual variability could inform researchers’ investigations … Continue reading Part 2 of Switch on your Nrf2 signaling pathway
This 2020 study investigated genes and signaling pathways for inflammatory memory: “Fibroblast-like synoviocytes (FLS) play a critical role in pathogenesis of rheumatoid arthritis (RA). Chronic inflammation induces transcriptomic and epigenetic modifications that imparts a persistent catabolic phenotype to the FLS, despite their dissociation from the inflammatory environment. Sustained activated genes established pro-inflammatory signaling components known … Continue reading Does reprogramming signaling pathways create memories?
This comprehensive 2020 rodent study investigated dozens of scenarios for β-glucan in the context of anti-tumor immunity: “Neutrophils and granulopoietic progenitors are major cellular effectors of β-glucan-induced trained immunity. The anti-tumor effect of β-glucan-induced trained immunity was mediated by qualitative changes in neutrophils. A tumor-suppressive phenotype in neutrophils was associated with training of granulopoiesis mediated … Continue reading Anti-tumor effects of β-glucan
This 2020 human/rodent study investigated treating and preventing skin photodamage with sulforaphane: “Alterations in NRF2 signaling have been implicated in aging and stress-induced skin pigmentation disorders in the skin and hair follicles. NRF2 signaling regulates transcriptional programs involved in adaption and survival of cells in the setting of oxidative stress, and oxidative stress occurs in … Continue reading Rub some broccoli sprouts on it
Did a little math to end this 28th week of eating a clinically relevant weight of microwaved broccoli sprouts every day: I changed the title of weekly updates after Week 7 as a result of A rejuvenation therapy and sulforaphane. Numbers used from its study: “Rats were injected four times on alternate days for 8 … Continue reading Week 28 of Changing to a youthful phenotype with broccoli sprouts
This 2020 meta-analysis subject was DHEA: “Twenty-four qualified trials were included in this meta-analysis. Statistically significant increases in serum IGF-1 levels were found only in participants who were: Women; or Supplementing 50 mg/d; or Undergoing intervention for > 12 weeks; or Without an underlying comorbidity; or Over the age of 60 years. DHEA supplementation led … Continue reading Take responsibility for your one precious life – DHEA