The epigenetic clock theory of aging

My 400th curation is a 2018 US/UK paper by coauthors of Using an epigenetic clock to distinguish cellular aging from senescence. They reviewed the current state of epigenetic clock research, and proposed a new theory of aging: “The proposed epigenetic clock theory of ageing views biological ageing as an unintended consequence of both developmental programmes … Continue reading The epigenetic clock theory of aging

Using an epigenetic clock to assess liver disease

This 2018 UC San Diego human study investigated the capability of the epigenetic clock methodology to detect biological aging with nonalcoholic steatohepatitis (NASH) patients: “The ability to measure a surrogate marker of liver aging from a peripheral blood sample has broad implications for assessing clinically “silent” chronic diseases, such as NASH, and, potentially, their response … Continue reading Using an epigenetic clock to assess liver disease

Using an epigenetic clock with older adults

This 2016 German human study found: “Epigenetic age acceleration is correlated with clinically relevant aging-related phenotypes through pathways unrelated to cellular senescence as assessed by telomere length. The current work employed the frailty index, a multi-dimensional approach that combines [34] parameters of multiple physiological systems and functional capacities. The present findings were based on [1,820] … Continue reading Using an epigenetic clock with older adults

Using an epigenetic clock with children

This 2015 UK human study by many of the coauthors of What’s the origin of the problem of being fat? applied the Horvath epigenetic clock method to the same UK mother-child pairs and a Danish cohort: “There has been no investigation on prenatal and antenatal factors that affect AA [age acceleration] in children. It is … Continue reading Using an epigenetic clock with children

Using an epigenetic clock to distinguish cellular aging from senescence

The 2016 UK/UCLA human study found: “Induction of replicative senescence (RS) and oncogene-induced senescence (OIS) are accompanied by ageing of the cell. However, senescence induced by DNA damage is not, even though RS and OIS activate the cellular DNA damage response pathway, highlighting the independence of senescence from cellular ageing. We used primary endothelial cells … Continue reading Using an epigenetic clock to distinguish cellular aging from senescence

The next phase of reversing aging and immunosenescent trends

Dr. Greg Fahy earlier this week provided an update on the November 2020 TRIIM-X follow-on to the September 2019 TRIIM curated in Reversal of aging and immunosenescent trends. Emphasis was on reproducibility: 23:45 Dr. Steve Horvath reanalyzed TRIIM for the plasma portion of Levine’s PhenoAge epigenetic clock. Results were congruent with four other epigenetic clocks … Continue reading The next phase of reversing aging and immunosenescent trends

Repositioning DNA methylation

This 2021 human study found: “We report on a randomized controlled clinical trial conducted among 43 healthy adult males between the ages of 50-72. The 8-week treatment program included diet, sleep, exercise and relaxation guidance, and supplemental probiotics and phytonutrients. This is the first randomized controlled study to suggest that specific diet and lifestyle interventions … Continue reading Repositioning DNA methylation

Rhythmicity

This 2021 review subject was circadian signaling in the digestive system: “The circadian system controls diurnal rhythms in gastrointestinal digestion, absorption, motility, hormones, barrier function, and gut microbiota. The master clock, located in the suprachiasmatic nucleus (SCN) region of the hypothalamus, is synchronized or entrained by the light–dark cycle and, in turn, synchronizes clocks present … Continue reading Rhythmicity

Gut microbiota and aging

This 2020 review explored the title subject: “The human body contains 1013 human cells and 1014 commensal microbiota. Gut microbiota play vital roles in human development, physiology, immunity, and nutrition. Human lifespan was thought to be determined by the combined influence of genetic, epigenetic, and environmental factors including lifestyle-associated factors such as exercise or diet. … Continue reading Gut microbiota and aging

Week 37 of Changing to a youthful phenotype with broccoli sprouts

1. Been wrong about a few things this past week: A. I thought in Week 28 that extrapolating A rejuvenation therapy and sulforaphane results to humans would produce personal results by this week. An 8-day rat treatment period ≈ 258 human days, and 258 / 7 ≈ 37 weeks. There are just too many unknowns … Continue reading Week 37 of Changing to a youthful phenotype with broccoli sprouts

Clearing out the 2020 queue of interesting papers

I’ve partially read these 39 studies and reviews, but haven’t taken time to curate them. Early Life Intergenerational Transmission of Cortical Sulcal Patterns from Mothers to their Children (not freely available) Differences in DNA Methylation Reprogramming Underlie the Sexual Dimorphism of Behavioral Disorder Caused by Prenatal Stress in Rats Maternal Diabetes Induces Immune Dysfunction in … Continue reading Clearing out the 2020 queue of interesting papers

Dietary contexts matter

Two papers illustrated how actions of food compounds are affected by their contexts. The first was a 2020 UCLA rodent study: “Long-chain polyunsaturated fatty acids (PUFAs), particularly omega-3 (n-3) PUFAs, have been indicated to play important roles in various aspects of human health. Controversies are observed in epidemiological and experimental studies regarding the benefits or … Continue reading Dietary contexts matter

Week 28 of Changing to a youthful phenotype with broccoli sprouts

Did a little math to end this 28th week of eating a clinically relevant weight of microwaved broccoli sprouts every day: I changed the title of weekly updates after Week 7 as a result of A rejuvenation therapy and sulforaphane. Numbers used from its study: “Rats were injected four times on alternate days for 8 … Continue reading Week 28 of Changing to a youthful phenotype with broccoli sprouts

Eat broccoli sprouts to pivot your internal environment’s signals

Two 2020 reviews covered some aspects of a broccoli sprouts primary action – NRF2 signaling pathway activation: “Full understanding of the properties of drug candidates rely partly on the identification, validation, and use of biomarkers to optimize clinical applications. This review focuses on results from clinical trials with four agents known to target NRF2 signaling … Continue reading Eat broccoli sprouts to pivot your internal environment’s signals