Benefits of eating fermentable fiber

This 2021 review subject was effects of short-chain fatty acids produced by gut microbiota: “SCFAs are the main players in the interplay between diet, microbiota, and health. SCFAs contribute to intestinal homeostasis and regulation of energy metabolism. SCFAs regulate the blood–brain barrier and neuroimmunoendocrine functions. During gestation, SCFAs can cause epigenetic imprinting and protect against … Continue reading Benefits of eating fermentable fiber

Every hand’s a winner, and every hand’s a loser

Another great blog post Know When To Fold ‘Em by Dr. Paul Clayton: “Newly formed proteins entering the endoplasmic reticulum must be correctly folded to achieve their final form and function. This is a complex procedure with a failure rate of over 80%. When metabolism is sufficiently skewed, accuracy of protein folding in the endoplasmic … Continue reading Every hand’s a winner, and every hand’s a loser

Several diseases, one treatment?

This 2021 review summarized three dietary supplements’ effects on psychiatric symptoms: “Upregulation of Nrf2 has been suggested as a common therapeutic target for major neuropsychiatric disorders. In this paper, evidence is presented showing how NAC [N-acetyl-cysteine], coenzyme Q10 (CoQ), and melatonin can ameliorate many important effects of oxidative stress by upregulating Nrf2. Given its key … Continue reading Several diseases, one treatment?

Repositioning DNA methylation

This 2021 human study found: “We report on a randomized controlled clinical trial conducted among 43 healthy adult males between the ages of 50-72. The 8-week treatment program included diet, sleep, exercise and relaxation guidance, and supplemental probiotics and phytonutrients. This is the first randomized controlled study to suggest that specific diet and lifestyle interventions … Continue reading Repositioning DNA methylation

Oat β-glucan effects on colitis

This 2021 rodent study investigated oat β-glucan effects on colitis: “In this study, we determined effects of consumption of low- and high-molar-mass oat beta-glucans on expression of selected markers of apoptosis and autophagy in colonocytes in TNBS colitis-induced rats. We analyzed expression of colon wall receptors, including TLRs and Dectin-1, which are involved in recognition … Continue reading Oat β-glucan effects on colitis

Gut microbiota topics

Here are thirty 2019 and 2020 papers related to Switch on your Nrf2 signaling pathway topics. Started gathering research on this particular theme three months ago. There are more researchers alive today than in the sum of all history, and they’re publishing. I can’t keep up with the torrent of interesting papers. 2020 A prebiotic … Continue reading Gut microbiota topics

Increase broccoli compound amounts with thermosonication

This 2021 study combined ultrasound and heat to increase broccoli compounds: “A large proportion of broccoli biomass is lost during primary production, distribution, processing, and consumption. This study evaluated thermosonication for pre-treatment of broccoli florets to enhance enzymatic conversion of glucoraphanin (GR) into bioactive sulforaphane (SF). Our results showed that a combination of ultrasound with … Continue reading Increase broccoli compound amounts with thermosonication

Microwave broccoli sprouts to increase sulforaphane

This 2020 review explored sulforaphane stability and formation: “Sulforaphane (SF) is beneficial to our health since it can reduce incidence of a number of tumors, induce cell cycle arrest and apoptosis in multiple experimental models. However, since neither SF nor myrosinase is thermostable, it is essential to increase stability of SF and/or enhance conversion of … Continue reading Microwave broccoli sprouts to increase sulforaphane

Year One of Changing to a youthful phenotype with broccoli sprouts

1. My subjective experiences these past 52 weeks are that noticeable changes keep happening due to combinations of: Eating clinically-relevant, twice-daily doses of microwaved 3-day-old broccoli sprouts, and taking nothing else an hour before or an hour after; Eating 3-day-old oat sprouts twice a day; Exercising every day; Taking yeast cell wall β-glucan and other … Continue reading Year One of Changing to a youthful phenotype with broccoli sprouts

β-glucan comparisons

This 2018 rodent study compared and contrasted commercially available β-glucans: “β-glucans are natural biologically-active compounds called ‘biological response modifiers.’ This study is a follow-up of our three previous studies that tested 43 different glucans. We used 16 different glucans isolated from yeasts, mushrooms, algae, and oats. We compared their effects on phagocytosis, IL-2 production, antibody … Continue reading β-glucan comparisons

Adaptive and innate immunity

Two 2021 reviews presented aspects of human immune systems: “The adaptive immune system’s challenge is to protect the host through generation and differentiation of pathogen‐specific short‐lived effector T cells, while in parallel developing long‐lived memory cells to control future encounters with the same pathogen. The system highly relies on self‐renewal of naïve and memory T … Continue reading Adaptive and innate immunity

Go with the Alzheimer’s Disease evidence

This 2021 study investigated gut microbiota differences between 100 AD patients and 71 age- and gender-matched controls: “Structural changes in fecal microbiota were evident in Chinese AD patients, with decreased alpha-diversity indices and altered beta-diversity ones, evidence of structurally dysbiotic AD microbiota. Interestingly, traditionally beneficial bacteria, such as Bifidobacterium and Akkermansia, increase in these AD … Continue reading Go with the Alzheimer’s Disease evidence

Harnessing endogenous defenses with broccoli sprouts

This 2019 article was by the author of Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. It isn’t widely available, so I’ll quote liberally: “Demand for solutions to digestive health issues is accelerating, especially since both scientific literature and popular press dedicate significant resources to … Continue reading Harnessing endogenous defenses with broccoli sprouts

It’s the fiber, not the fat

I came across this 2020 fiber-vs-fat rodent study from its citation in Gut microbiota and aging: “Dietary intervention studies largely revolve around altering fat content. Little consideration has been given to amount of fiber and whether or not it is soluble. We examined age- and sex-specific effects of a refined high-fat/low soluble fiber diet (rHFD) … Continue reading It’s the fiber, not the fat

Gut microbiota and aging

This 2020 review explored the title subject: “The human body contains 1013 human cells and 1014 commensal microbiota. Gut microbiota play vital roles in human development, physiology, immunity, and nutrition. Human lifespan was thought to be determined by the combined influence of genetic, epigenetic, and environmental factors including lifestyle-associated factors such as exercise or diet. … Continue reading Gut microbiota and aging