Broccoli sprouts and microRNAs

This 2021 in vitro study investigated microRNAs as potential causative factors for broccoli’s beneficial effects: “A computational analysis was performed to explore processes and pathways associated with genes targeted either by: Host-expressed miRNAs (endogenous) modulated by bioactive compounds in broccoli; or miRNAs derived from broccoli (exogenous). miRNAs are noncoding RNAs containing between 19 and 24 … Continue reading Broccoli sprouts and microRNAs

Eat isoflavones for your nerves

This 2021 rodent study investigated effects of dietary isoflavones and gut microbiota: “Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system (CNS) that results in sensory, motor, and/or cognitive dysfunction. This is due to complex interactions of genetic and environmental factors that trigger activation of autoreactive T cells, leading to subsequent … Continue reading Eat isoflavones for your nerves

Epigenetic clocks so far in 2021

2021’s busiest researcher took time out this month to update progress on epigenetic clocks: Hallmarks of aging aren’t all associated with epigenetic aging. Interventions that increase cellular lifespan aren’t all associated with epigenetic aging. Many of his authored or coauthored 2021 papers developed human / mammalian species relative-age epigenetic clocks. Relative-age epigenetic clocks better predict … Continue reading Epigenetic clocks so far in 2021

Gut microbiota and critical development periods

This 2021 rodent study focused on global histone acetylation as a model to understand roles of microbially produced short-chain fatty acids in liver function: “Despite the utility of germ-free mice in probing complex interactions between gut microbiota and host physiology, germ-free mice are developmentally, physiologically, and metabolically unique when compared with their conventionally housed counterparts. … Continue reading Gut microbiota and critical development periods

Eat oat avenanthramides for your gut microbiota

This 2021 paper covered a 2016 human clinical trial, and several in vitro and rodent follow-up studies: “Oat has been widely accepted as a key food for human health. It is becoming increasingly evident that individual differences in metabolism determine how different individuals benefit from diet. Both host genetics and gut microbiota play important roles … Continue reading Eat oat avenanthramides for your gut microbiota

Part 2 of Improving epigenetic clocks’ signal-to-noise ratio

Another excellent blog post by Josh Mitteldorf, A New Approach to Methylation Clocks, that curated the same study: “The Levine/Horvath PhenoAge epigenetic clock was calibrated using a combination of metabolic factors that correlate with health, including inflammation, DNA transcription, DNA repair, and mitochondrial activity. Evolution is not an engineer. Living things are not constructed out … Continue reading Part 2 of Improving epigenetic clocks’ signal-to-noise ratio

Choosing appropriate dietary fibers

This 2021 rodent study investigated effects of dietary fibers on Type 2 diabetes: “Nine types of dietary fibers were used to investigate and evaluate their effects on type-2 diabetic rats via physiology, genomics, and metabolomics. In human clinical trials, supplementation with dietary fibers was found inversely associated with risks of diabetes, along with improvement on … Continue reading Choosing appropriate dietary fibers

Gut reaction

Two papers on broccoli compounds and gut microbiota relationships, with the first a 2021 article: “We provide a supportive environment and a supply of nutrition and, in return, the microbiome delivers benefits to our health. What exactly are those benefits, and how can we maximise them? Fibre component of food was thought to be completely … Continue reading Gut reaction

An IBD trigger?

Three papers on interactions of the virus and inflammatory bowel disease, beginning with a 2021 review: “Analysis signaling pathways of innate and adaptive immunity components during SARS-CoV-2 infection in IBD (inflammatory bowel disease) patients through a putative alternative route – the gastrointestinal tract, with virus attachment to ACE2 (angiotensin-converting enzyme 2) expressed on IECs (intestinal … Continue reading An IBD trigger?

Gut microbiota strains

Three human studies investigated strains within microbiota species. The first from 2021 had obese child subjects: “Dietary intervention is effective in human health promotion through modulation of gut microbiota. Diet can cause single-nucleotide polymorphisms (SNPs) to occur in gut microbiota, and some of these variations may lead to functional changes in human health. Compared with … Continue reading Gut microbiota strains

Prevent your brain from shrinking

My 800th curation is a 2021 human diet and lifestyle study: “Brain atrophy is correlated with risk of cognitive impairment, functional decline, and dementia. This study (a) examines the statistical association between brain volume (BV) and age for Tsimane, and (b) compares this association to that of 3 industrialized populations in the United States and … Continue reading Prevent your brain from shrinking

If you aren’t where you want to be, change yourself

This 2021 human study evaluated associations among epigenetic clocks and socioeconomic status: “We conducted a comprehensive, comparative analysis of associations between various dimensions of socioeconomic status (SES) (education, income, wealth, occupation, neighbourhood environment, and childhood SES) and eight epigenetic clocks in two well-powered US ageing studies: The Multi-Ethnic Study of Atherosclerosis (MESA); and The Health … Continue reading If you aren’t where you want to be, change yourself

Part 2 of Make your gut microbiota happy

Continuing from Part 1, 7/15/2021 test results received 7/27 showed I was putatively below average in four gut bacteria. The most relatively deficient (percentage-wise) were populations in genus Bifidobacterium: Looking through Thryve’s recommended foods, eating all but one (green lentils) of twenty legumes increased genus Bifidobacterium. Here’s a sample: I already had dried garbanzo and … Continue reading Part 2 of Make your gut microbiota happy

Back pain and advanced glycation end products (AGEs)

Two 2020 rodent studies investigated intervertebral disk degeneration, with the first on AGEs’ role: “This study evaluated the role of AGEs and RAGE in driving early intervertebral disk (IVD) degeneration processes in mice. Aging and diabetes are associated with increased low-back pain and IVD degeneration, yet causal mechanisms remain uncertain. AGEs: Accumulate in IVDs from … Continue reading Back pain and advanced glycation end products (AGEs)

ω-6 to ω-3 PUFA ratio

Three human-evidenced publications on omega-6 and omega-3 polyunsaturated fatty acids, with the first a 2021 blog post that cited 72 references: “In the area of heart health, which is why most consumers swallow fish oil, the data is hopelessly conflicted: One meta-analyses found that protective effects were dose-related, which is always persuasive; In marked contrast, … Continue reading ω-6 to ω-3 PUFA ratio