Adverse effects of inflammation and stress on hippocampal synapses

This dense and highly-jargoned 2015 rodent study found: “The suppression of BDNF [brain-derived neurotrophic factor] signaling, LTP [long-term potentiation], and memory may be driven by an increased sensitivity to IL-1β [the proinflammatory cytokine interleukin 1β] that occurs directly at synapses.” The researchers reversed the adverse effects of IL-1β after they induced stress and inflammation. Blocking … Continue reading Adverse effects of inflammation and stress on hippocampal synapses

A common dietary supplement that has rapid and lasting antidepressant effects

This 2012 Italian rodent study found that a common dietary supplement had rapid and lasting antidepressant effects: “Remarkably, L-acetylcarnitine displayed a clear-cut antidepressant effect already after 3 and 7 d[ays] of daily dosing. No tolerance was developed to the action of L-acetylcarnitine. The drug was even more effective after 21 d[ays], and the effect persisted for … Continue reading A common dietary supplement that has rapid and lasting antidepressant effects