Is the purpose of research to define opportunities for interventions?

In this 2014 review, a social scientist first presented an interpretive history of what he found to be important in the emergence of epigenetics. He proceeded into his ideas of “a possible agenda of the social studies of the life-sciences” in the “postgenomic age” with headings such as “Postgenomic biopolitics: “upgrade yourself” or born damaged … Continue reading Is the purpose of research to define opportunities for interventions?

Welcome – How Primal Therapy relates to recent scientific research

What does Primal Therapy have to do with science? To illustrate how applying principles of Dr. Arthur Janov’s Primal Therapy can provide additional information that’s relevant to recent scientific research, let’s start with the How do we assess “importance” in our lives? An example from scientists’ research choices study. Do you agree that a person’s … Continue reading Welcome – How Primal Therapy relates to recent scientific research

Is it science, or is it a silly and sad farce when researchers “make up” missing data?

This 2014 French study was a parody of science. The researchers “made up” missing data on over 50% of the men and over 47% of the women! All to satisfy their model that drove an agenda of the effects of adverse childhood experiences. As an example of how silly and sad this was: Two of … Continue reading Is it science, or is it a silly and sad farce when researchers “make up” missing data?

Vascular memory

This 2022 rodent study investigated effects of inducing hypertension for two weeks: “Hypertension is conventionally associated with a neurohormonal activation from the sympathetic nervous and the renin-angiotensin-aldosterone systems. Angiotensin II (AngII) is a potent regulator of blood pressure, and is also a key player in hypertension development. An initial 2-week exposure to AngII induced profound … Continue reading Vascular memory

Take acetyl-L-carnitine for early-life trauma

This 2021 rodent study traumatized female mice during their last 20% of pregnancy, with effects that included: Prenatally stressed pups raised by stressed mothers had normal cognitive function, but depressive-like behavior and social impairment; Prenatally stressed pups raised by control mothers did not reverse behavioral deficits; and Control pups raised by stressed mothers displayed prenatally … Continue reading Take acetyl-L-carnitine for early-life trauma

Our first 1000 days

This 2021 review subject was a measurable aspect of our early lives: “The first 1000 days from conception are a sensitive period for human development programming. During this period, environmental exposures may result in long-lasting epigenetic imprints that contribute to future developmental trajectories. The present review reports on effects of adverse and protective environmental conditions … Continue reading Our first 1000 days

A drug that countered effects of a traumatizing mother

This 2019 US rodent study concerned transmitting poor maternal care to the next generation: “The quality of parental care received during development profoundly influences an individual’s phenotype, including that of maternal behavior. Infant experiences with a caregiver have lifelong behavioral consequences. Maternal behavior is a complex behavior requiring the recruitment of multiple brain regions including … Continue reading A drug that countered effects of a traumatizing mother

Our brains are shaped by our early environments

This 2019 McGill paper reviewed human and animal studies on brain-shaping influences from the fetal period through childhood: “In neonates, regions of the methylome that are highly variable across individuals are explained by the genotype alone in 25 percent of cases. The best explanation for 75 percent of variably methylated regions is the interaction of … Continue reading Our brains are shaped by our early environments

Prenatal programming of human HPA axis development

This 2017 UC Irvine human review subject provided details of how fetal hypothalamic-pituitary-adrenal components and systems develop, and how they are epigenetically changed by the mother’s environment: “The developmental origins of disease or fetal programming model predicts that intrauterine exposures have life-long consequences for physical and psychological health. Prenatal programming of the fetal hypothalamic-pituitary-adrenal (HPA) … Continue reading Prenatal programming of human HPA axis development

A disturbance in the paradigm of child abuse

The principal way science advances is through a principle Einstein expressed as: “No amount of experimentation can ever prove me right; a single experiment can prove me wrong.” The scientific community and public should be satisfied that the scientific process is working well when hypotheses are discarded due to nonconfirming evidence. Researchers should strive to … Continue reading A disturbance in the paradigm of child abuse

Manufacturing PTSD evidence with machine learning

What would you do if you were a scientist who had strong beliefs that weren’t borne out by experimental evidence? Would you be honest with yourself about the roots of the beliefs? Would you attempt to discover why the beliefs were necessary for you, and what feelings were associated with the beliefs? Instead of the … Continue reading Manufacturing PTSD evidence with machine learning

The pain societies instill into children

The human subjects of this 2017 Swiss study had previously been intentionally traumatized by Swiss society: “Swiss former indentured child laborers (Verdingkinder) were removed as children from their families by the authorities due to different reasons (poverty, being born out of wedlock) and were placed to live and work on farms. This was a practice … Continue reading The pain societies instill into children

Do preventive interventions for children of mentally ill parents work?

The fifth and final paper of Transgenerational epigenetic inheritance week was a 2017 German/Italian meta-analysis of psychiatric treatments involving human children: “The transgenerational transmission of mental disorders is one of the most significant causes of psychiatric morbidity. Several risk factors for children of parents with mental illness (COPMI) have been identified in numerous studies and meta-analyses. … Continue reading Do preventive interventions for children of mentally ill parents work?

Transgenerational pathological traits induced by prenatal immune activation

The third paper of Transgenerational epigenetic inheritance week was a 2016 Swiss rodent study of immune system epigenetic effects: “Our study demonstrates for, we believe, the first time that prenatal immune activation can negatively affect brain and behavioral functions in multiple generations. These findings thus highlight a novel pathological aspect of this early-life adversity in shaping … Continue reading Transgenerational pathological traits induced by prenatal immune activation

Transgenerational effects of early environmental insults on aging and disease

The first paper of Transgenerational epigenetic inheritance week was a 2017 Canadian/Netherlands review that’s organized as follows: “First, we address mechanisms of developmental and transgenerational programming of disease and inheritance. Second, we discuss experimental and clinical findings linking early environmental determinants to adverse aging trajectories in association with possible parental contributions and sex-specific effects. Third, we … Continue reading Transgenerational effects of early environmental insults on aging and disease