Search Results for: prs

Prenatal stress heightened adult chronic pain

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This 2019 McGill rodent study found: “Prenatal stress exacerbates pain after injury. Analysis of mRNA expression of genes related to epigenetic regulation and stress responses in the frontal cortex and hippocampus, brain structures implicated in chronic pain, showed distinct sex and region-specific patterns of dysregulation. In general, mRNA expression was most frequently altered in the … Continue reading Prenatal stress heightened adult chronic pain

Perinatal stress and sex differences in circadian activity

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This 2019 French/Italian rodent study used the PRS model to investigate its effects on circadian activity: “The aim of this study was to explore the influence of PRS on the circadian oscillations of gene expression in the SCN [suprachiasmatic nucleus of the hypothalamus] and on circadian locomotor behavior, in a sex-dependent manner. Research on transcriptional … Continue reading Perinatal stress and sex differences in circadian activity

The lifelong impact of maternal postpartum behavior

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This 2018 French/Italian/Swiss rodent study was an extension of the work done by the group of researchers who performed Prenatal stress produces offspring who as adults have cognitive, emotional, and memory deficiencies and Treating prenatal stress-related disorders with an oxytocin receptor agonist: “Reduction of maternal behavior [nursing behavior, grooming, licking, carrying pups] was predictive of … Continue reading The lifelong impact of maternal postpartum behavior

Prenatal stress produces offspring who as adults have cognitive, emotional, and memory deficiencies

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This 2018 French/Italian/Swiss rodent study used a prenatally restraint stressed (PRS) model to create problems that could be resolved by various chemicals: “S 47445 is a positive modulator of glutamate AMPA-type receptors, possessing neurotrophic and enhancing synaptic plasticity effects as well as pro-cognitive and anti-stress properties. Most of studies examining the antidepressant effects of new … Continue reading Prenatal stress produces offspring who as adults have cognitive, emotional, and memory deficiencies

Treating prenatal stress-related disorders with an oxytocin receptor agonist

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This 2015 French/Italian rodent study found: “Chronic systemic treatment with carbetocin [unavailable in the US] in PRS [prenatally restraint stressed] rats corrected: the defect in glutamate release, anxiety– and depressive-like behavior, and abnormalities: in social behavior, in the HPA response to stress, and in the expression of stress-related genes in the hippocampus and amygdala. These … Continue reading Treating prenatal stress-related disorders with an oxytocin receptor agonist