Epigenetic transgenerational inheritance of ovarian disease

This 2018 Washington rodent study investigated ovarian disease in F3 great-granddaughters caused by their F0 great-grandmothers’ exposures to DDT or vinclozolin while pregnant: “Two of the most prevalent ovarian diseases affecting women’s fertility and health are Primary Ovarian Insufficiency (POI) and Polycystic Ovarian Syndrome (PCOS). POI is characterized by a marked reduction in the primordial … Continue reading Epigenetic transgenerational inheritance of ovarian disease

A problematic study of testosterone’s influence on behavior and brain measurements

This 2015 US/Canadian human study of people ages 6 to 22 years found: “Testosterone-specific associations between amygdala volume and key prefrontal areas involved in emotional regulation and impulse control: Testosterone-specific modulation of the covariance between the amygdala and medial prefrontal cortex (mPFC); A significant relationship between amygdala-mPFC covariance and levels of aggression; and Mediation effects … Continue reading A problematic study of testosterone’s influence on behavior and brain measurements

Fetal exposure to sex hormones and female anxiety

This 2015 Swedish rodent study found: “Women with polycystic ovary syndrome (PCOS) display high circulating androgen levels that may affect the fetus and increase the risk of mood disorders in offspring. Although clinical data are inconsistent, there are indications that androgens play a crucial role in behavior and mood regulation in females. Studies on the … Continue reading Fetal exposure to sex hormones and female anxiety

Sex hormone exposure to the developing female fetus causes infertility in adulthood

This 2014 rodent study was of polycystic ovarian syndrome, which is the leading cause of human female infertility. The researchers could reliably induce this disease in mice while they were still fetuses, but effects didn’t manifest until adulthood! The inducement method exposed the developing female fetuses to androgens such that their testosterone concentration was significantly … Continue reading Sex hormone exposure to the developing female fetus causes infertility in adulthood